[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5483/BMBRep.2013.46.8.014

Curcumin ameliorates TNF-α-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells

Youn, Gi Soo (Department of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University)
Kwon, Dong-Joo (Department of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University)
Ju, Sung Mi (Department of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University)
Choi, Soo Young (Department of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University)
Park, Jinseu (Department of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University)

Publication Information

BMB Reports / v.46, no.8, 2013 , pp. 410-415 More about this Journal

Abstract

Adhesion molecules such as ICAM-1 are important in the infiltration of leukocytes into the site of inflammation. In this study, we investigated the inhibitory effects of curcumin on ICAM-1 expression and monocyte adhesiveness as well as its underlying action mechanism in the TNF- ${\alpha}$ -stimulated keratinocytes. Curcumin induced expression of heme oxygenase-1 (HO-1) in the human keratinocyte cell line HaCaT. In addition, curcumin induced Nrf2 activation in dose- and time-dependent manners in the HaCaT cells. Curcumin suppressed TNF- ${\alpha}$ -induced ICAM-1 expression and subsequent monocyte adhesion, which were reversed by the addition of tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, or HO-1 knockdown using siRNA. Furthermore, Nrf2 knockdown using siRNA reversed the inhibitory effect of curcumin on the TNF- ${\alpha}$ -induced ICAM-1 expression and adhesion of monocytes to keratinocytes. These results suggest that curcumin may exert its anti-inflammatory activity by suppressing the TNF- ${\alpha}$ -induced ICAM-1 expression and subsequent monocyte adhesion via expression of HO-1 in the keratinocytes.

Keywords

Curcumin; HO-1; ICAM-1; Inflammation; Keratinocyte;

Citations & Related Records

Times Cited By KSCI : 3 (Citation Analysis)

Reference
Cited By KSCI

1	Kim, A. N., Jeon, W. K., Lee, J. J. and Kim B. C. (2010) Up-regulation of heme oxygenase-1 expression through CaMKII-ERK1/2-Nrf2 signaling mediates the anti-inflammatory effect of bisdemethoxycurcumin in LPS-stimulated macrophages. Free Radic. Biol. Med. 49, 323-331. DOI ScienceOn
2	Hsu, H. Y., Chu, L. C., Hua, K. F. and Chao L. K. (2008) Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes. J. Cell Physiol. 215, 603-612. DOI ScienceOn
3	Kumar, A., Dhawan, S., Hardegen, N. J. and Aggarwal B. B. (1998) Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor- kappaB activation. Biochem. Pharmacol. 55, 775-783. DOI ScienceOn
4	Gupta, B. and Ghosh B. (1999) Curcuma longa inhibits TNF-alpha induced expression of adhesion molecules on human umbilical vein endothelial cells. Int. J. Immunopharmacol. 21, 745-757. DOI ScienceOn
5	Bito, T., Roy, S., Sen, C. K. and Packer L. (2000) Pine bark extract pycnogenol downregulates IFN-gamma-induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-1 expression. Free Radic. Biol. Med. 28, 219-227. DOI ScienceOn
6	Kostyuk, V., Potapovich, A. and De Luca C. (2010) The promise of plant polyphenols as the golden standard skin anti-inflammatory agents. Curr. Drug. Metab. 11, 414-424.
7	Olszanecki, R., Gebska, A. and Korbut R. (2007) The role of haem oxygenase-1 in the decrease of endothelial intercellular adhesion molecule-1 expression by curcumin. Basic Clin. Pharmacol. Toxicol. 101, 411-415. DOI ScienceOn
8	Seo, W. Y., Goh, G. R., Ju, S. M., Song, H. Y., Kwon, D. J., Jun, J. G., Kim, B. C., Choi, S. Y. and Park J. (2011) Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells. Biochem. Biophys. Res. Commun. 407, 535-540. DOI ScienceOn
9	Paine, A., Eiz-Vesper, B., Blasczyk, R. and Immenschuh S. (2010) Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. Biochem. Pharmacol. 80, 1895-1903. DOI ScienceOn
10	Song, H. Y., Ju, S. M., Goh, A. R., Kwon, D. J., Choi, S. Y. and Park, J. (2011) Suppression of TNF-alpha-induced MMP-9 expression by a cell-permeable superoxide dismutase in keratinocytes. BMB Rep. 44, 462-467. 과학기술학회마을 DOI ScienceOn
11	Lee, S. H., Kim, D. W., Eom, S. A., Jun, S. Y., Park, M., Kim, D. S., Kwon, H. J., Kwon, H. Y., Han, K. H., Park, J., Hwang, H. S., Eum, W. S. and Choi, S. Y. (2012) Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein. BMB Rep. 45, 354-359. 과학기술학회마을 DOI ScienceOn
12	Park, L. J., Ju, S. M., Song, H. Y., Lee, J. A., Yang, M. Y., Kang, Y. H., Kwon, H. J., Kim, T. Y., Choi, S. Y. and Park, J. (2006) The enhanced monocyte adhesiveness after UVB exposure requires ROS and NF-kappaB signaling in human keratinocyte. J. Biochem. Mol. Biol. 39, 618-625. 과학기술학회마을 DOI ScienceOn
13	Seo, W. Y., Ju, S. M., Song, H. Y., Goh, A. R., Jun, J. G., Kang, Y. H., Choi, S. Y. and Park J. (2010) Celastrol suppresses IFN-gamma-induced ICAM-1 expression and subsequent monocyte adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells. Biochem. Biophys. Res. Commun. 398, 140-145. DOI ScienceOn
14	Cho, J. W., Lee, K. S. and Kim C. W. (2007) Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NFkappaB and MAPKs as potential upstream targets. Int. J. Mol. Med. 19, 469-474.
15	Pae, H. O., Ha, Y. A., Chai, K. Y. and Chung H. T. (2008) Heme oxygenase-1 attenuates contact hypersensitivity induced by 2,4-dinitrofluorobenzene in mice. Immunopharmacol Immunotoxicol. 30, 207-216. DOI ScienceOn
16	Motterlini, R., Foresti, R., Bassi, R. and Green C. J. (2000) Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic. Biol. Med. 28, 1303-1312. DOI ScienceOn
17	Krutmann, J., Kock, A., Schauer, E., Parlow, F., Moller, A., Kapp, A., Forster, E., Schopf, E. and Luger T. A. (1990) Tumor necrosis factor beta and ultraviolet radiation are potent regulators of human keratinocyte ICAM-1 expression. J. Invest. Dermatol. 95, 127-131. DOI ScienceOn
18	Grone, A. (2002) Keratinocytes and cytokines, Vet. Immunol. Immunopathol. 88, 1-12. DOI ScienceOn
19	Dustin, M. L., Singer, K. H., Tuck, D. T. and Springer T. A. (1988) Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1). J. Exp. Med. 167, 1323-1340. DOI ScienceOn
20	Barker, J. N., Sarma, V., Mitra, R. S., Dixit, V. M. and Nickoloff B. J. (1990) Marked synergism between tumor necrosis factor-alpha and interferon-gamma in regulation of keratinocyte-derived adhesion molecules and chemotactic factors. J. Clin. Invest. 85, 605-608. DOI ScienceOn
21	Zhou, H., Beevers, C. S. and Huang S. (2011) The targets of curcumin. Curr. Drug. Targets. 12, 332-347. DOI
22	Thangapazham, R. L., Sharma, A., and Maheshwari R. K. (2007) Beneficial role of curcumin in skin diseases. Adv. Exp. Med. Biol. 595, 343-357. DOI ScienceOn
23	Cho, J. W., Park, K., Kweon, G. R., Jang, B. C., Baek, W. K., Suh, M. H., Kim, C. W., Lee, K. S. and Suh S. I. (2005) Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets. Exp. Mol. Med. 37, 186-192. DOI ScienceOn
24	Grandjean-Laquerriere, A., Gangloff, S. C., Le Naour, R., Trentesaux, C., Hornebeck, W. and Guenounou M. (2002) Relative contribution of NF-kappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes. Cytokine. 18, 168-177. DOI ScienceOn
25	Kirino, M., Kirino, Y., Takeno, M., Nagashima, Y., Takahashi, K., Kobayashi, M., Murakami, S., Hirasawa, T., Ueda, A., Aihara, M., Ikezawa, Z. and Ishigatsubo Y. (2008) Heme oxygenase 1 attenuates the development of atopic dermatitis-like lesions in mice: implications for human disease. J. Allergy. Clin. Immunol. 122, 290-297. DOI ScienceOn
26	Lee, J. H., Kim, J. W., Ko, N. Y., Mun, S. H., Her, E., Kim, B. K., Han, J. W., Lee, H. Y., Beaven, M. A., Kim, Y. M. and Choi W. S. (2008) Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk. J. Allergy Clin. Immunol. 121, 1225-1231. DOI ScienceOn
27	Ryter, S. W., Alam, J. and Choi A. M. (2006) Heme oxygenase- 1/carbon monoxide: from basic science to therapeutic applications. Physiol. Rev. 86, 583-650. DOI ScienceOn
28	Listopad, J., Asadullah, K., Sievers, C., Ritter, T., Meisel, C., Sabat, R. and Docke W. D. (2007) Heme oxygenase-1 inhibits T cell-dependent skin inflammation and differentiation and function of antigen-presenting cells. Exp. Dermatol. 16, 661-670. DOI ScienceOn
29	Rattan, S. I., Fernandes, R. A., Demirovic, D., Dymek, B. and Lima C. F. (2009) Heat stress and hormetin-induced hormesis in human cells: effects on aging, wound healing, angiogenesis, and differentiation. Dose Response. 7, 90-103. DOI ScienceOn
30	Lima, C. F., Pereira-Wilson, C. and Rattan S. I. (2011) Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: relevance for anti-aging intervention. Mol. Nutr. Food Res. 55, 430-442. DOI ScienceOn
31	Berge, U., Kristensen, P. and Rattan S. I. (2008) Hormetic modulation of differentiation of normal human epidermal keratinocytes undergoing replicative senescence in vitro. Exp. Gerontol. 43, 658-662. DOI ScienceOn

5	Liyun Liu. (2015) Clinical and Experimental Pharmacology and Physiology Curcumin ameliorates asthmatic airway inflammation by activating nuclear factor-E2-related factor 2/haem oxygenase (HO)-1 signalling pathway / 42 (5) , 520
1	Hyejin Kim. (2016) BMB Reports 2,3-Dimethoxy-2′-hydroxychalcone ameliorates TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness via NF-kappaB inhibition and HO-1 induction in HaCaT cells / 49 (1) , 57
1	Hye Rim Park. (2014) Molecular & Cellular Toxicology Microarray analysis of gene expression in 3-methylcholanthrene-treated human endothelial cells / 10 (1) , 19
12	Behrooz Soltani. (2016) Biotechnology Letters Nanoformulation of curcumin protects HUVEC endothelial cells against ionizing radiation and suppresses their adhesion to monocytes: potential in prevention of radiation-induced atherosclerosis / 38 (12) , 2081
9	Won Yong Seo. (2015) BMB Reports Butein, a tetrahydroxychalcone, suppresses pro-inflammatory responses in HaCaT keratinocytes / 48 (9) , 495
1	Ki-Choon Choi. (2016) Food Science and Biotechnology Red bean extracts protect rats against intestinal inflammatory damage / 25 (1) , 349
3	Sung Mi Ju. (2015) BMB Reports Celastrol ameliorates cytokine toxicity and pro-inflammatory immune responses by suppressing NF-κB activation in RINm5F beta cells / 48 (3) , 172
2	Gun Woo Son. (2014) BioChip Journal Alteration of gene expression profile by melatonin in endothelial cells / 8 (2) , 91
6	Dong-Joo Kwon. (2014) BMB Reports Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-κB and JNK activation in RAW 264.7 macrophages / 47 (6) , 318
1	Wen-Chung Huang. (2015) International Immunopharmacology Phloretin ameliorates chemokines and ICAM-1 expression via blocking of the NF-κB pathway in the TNF-α-induced HaCaT human keratinocytes / 27 (1) , 32
1	Seung Eun Lee. (2015) Journal of Cardiovascular Pharmacology Effects of Eicosapentaenoic Acid on the Cytoprotection Through Nrf2-Mediated Heme Oxygenase-1 in Human Endothelial Cells / 66 (1) , 108
	Ki-Choon Choi. (2016) Journal of Ethnopharmacology Intestinal anti-inflammatory activity of the seeds of Raphanus sativus L. in experimental ulcerative colitis models / 179 , 55
7	Ah Ra Goh. (2016) Journal of Medicinal Food Aronia melanocarpaConcentrate Ameliorates Pro-Inflammatory Responses in HaCaT Keratinocytes and 12-O-Tetradecanoylphorbol-13-Acetate-Induced Ear Edema in Mice / 19 (7) , 654
	Chuan Li. (2016) Redox Biology Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction / 9 , 104
2	Sung-Ho Kook. (2015) International Immunopharmacology Catechin-7-O- β -D-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats / 29 (2) , 521
	Chian-Jiun Liou. (2014) Journal of Ethnopharmacology Casticin inhibits COX-2 and iNOS expression via suppression of NF-κB and MAPK signaling in lipopolysaccharide-stimulated mouse macrophages / 158 , 310
5	(2017) International Journal of Molecular Medicine PKCζ as a promising therapeutic target for TNFα-induced inflammatory disorders in chronic cutaneous wounds / 40 (5) , 1335
6	Wen-Chung Huang. (2015) Food Funct. Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 expression through inhibition of MAPK, Akt, and NF-κB signaling in human lung epithelial cells / 6 (6) , 1960

1	Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-κB and JNK activation in RAW 264.7 macrophages / [Kwon, Dong-Joo;Bae, Young-Soo;Ju, Sung Mi;Youn, Gi Soo;Choi, Soo Young;Park, Jinseu;] / BMB Reports
2	Alteration of Gene Expression Profile by Melatonin in Endothelial Cells / [Son, Gun Woo;Kim, Gun-Dong;Yang, Hana;Park, Hye Rim;Park, Yong Seek;] / BioChip Journal
3	Microarray analysis of gene expression in 3-methylcholanthrene-treated human endothelial cells / [Park, Hye Rim;Yang, Hana;Kim, Gun-Dong;Son, Gun Woo;Park, Yong Seek;] / Molecular & Cellular Toxicology