[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5483/BMBRep.2013.46.10.037

Gymnaster koraiensis and its major components, 3,5-di-O-caffeoylquinic acid and gymnasterkoreayne B, reduce oxidative damage induced by tert-butyl hydroperoxide or acetaminophen in HepG2 cells

Jho, Eun Hye (Functional Food Center, Korea Institute of Science and Technology)
Kang, Kyungsu (Functional Food Center, Korea Institute of Science and Technology)
Oidovsambuu, Sarangerel (Functional Food Center, Korea Institute of Science and Technology)
Lee, Eun Ha (Functional Food Center, Korea Institute of Science and Technology)
Jung, Sang Hoon (Functional Food Center, Korea Institute of Science and Technology)
Shin, Il-Shik (Department of Applied Marine Biotechnology and Engineering, Gangneung-Wonju National University)
Nho, Chu Won (Functional Food Center, Korea Institute of Science and Technology)

Publication Information

BMB Reports / v.46, no.10, 2013 , pp. 513-518 More about this Journal

Abstract

We investigated the protective effects of Gymnaster koraiensis against oxidative stress-induced hepatic cell damage. We used two different cytotoxicity models, i.e., the administration of tert-butyl hydroperoxide (t-BHP) and acetaminophen, in HepG2 cells to evaluate the protective effects of G. koraiensis. The ethyl acetate (EA) fraction of G. koraiensis and its major compound, 3,5-di-O-caffeoylquinic acid (DCQA), exerted protective effects in the t-BHP-induced liver cytotoxicity model. The EA fraction and DCQA ameliorated t-BHP-induced reductions in GSH levels and exhibited free radical scavenging activity. The EA fraction and DCQA also significantly reduced t-BHP-induced DNA damage in HepG2 cells. Furthermore, the hexane fraction of G. koraiensis and its major compound, gymnasterkoreayne B (GKB), exerted strong hepatoprotection in the acetaminophen-induced cytotoxicity model. CYP 3A4 enzyme activity was strongly inhibited by the extract, hexane fraction, and GKB. The hexane fraction and GKB ameliorated acetaminophen-induced reductions in GSH levels and protected against cell death.

Keywords

Gymnaster koraiensis; Gymnasterkoreayne B; Hepatoprotection; HepG2; Wild vegetable;

Citations & Related Records

Times Cited By KSCI : 4 (Citation Analysis)

Reference
Cited By KSCI

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