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http://dx.doi.org/10.5483/BMBRep.2013.46.10.223

Differential expression of the metastasis suppressor KAI1 in decidual cells and trophoblast giant cells at the feto-maternal interface  

Koo, Tae Bon (Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University)
Han, Min-Su (Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University)
Tadashi, Yamashita (WCU and BK21 Plus Program, Kyungpook National University)
Seong, Won Joon (Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University)
Choi, Je-Yong (Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University)
Publication Information
BMB Reports / v.46, no.10, 2013 , pp. 507-512 More about this Journal
Abstract
Invasion of trophoblasts into maternal uterine tissue is essential for establishing mature feto-maternal circulation. The trophoblast invasion associated with placentation is similar to tumor invasion. In this study, we investigated the role of KAI1, an anti-metastasis factor, at the maternal-fetal interface during placentation. Mouse embryos were obtained from gestational days 5.5 (E5.5) to E13.5. Immunohistochemical analysis revealed that KAI1 was expressed on decidual cells around the track made when a fertilized ovum invaded the endometrium, at days E5.5 and E7.5, and on trophoblast giant cells, along the central maternal artery of the placenta at E9.5. KAI1 in trophoblast giant cells was increased at E11.5, and then decreased at E13.5. Furthermore, KAI1 was upregulated during the forskolin-mediated trophoblastic differentiation of BeWo cells. Collectively, these results indicate that KAI1 is differentially expressed in decidual cells and trophoblasts at the maternal-fetal interface, suggesting that KAI1 prevents trophoblast invasion during placentation.
Keywords
Decidual cells; KAI1; Placenta; Trophoblast giant cells;
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Times Cited By KSCI : 2  (Citation Analysis)
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