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http://dx.doi.org/10.5483/BMBRep.2013.46.10.141

The role of interleukin-17 in bone metabolism and inflammatory skeletal diseases  

Lee, Youngkyun (Department of Biochemistry and Institute for Hard Tissue & Bio-tooth Regeneration (IHBR), School of Dentistry, Kyungpook National University)
Publication Information
BMB Reports / v.46, no.10, 2013 , pp. 479-483 More about this Journal
Abstract
The balance between osteoblast-dependent bone formation and osteoclast-dependent bone resorption maintains bone homeostasis. In inflammatory conditions, this balance shifts toward bone resorption, causing osteolytic bone lesions observed in rheumatoid arthritis and periodontitis. A recently discovered family of cytokine IL-17 is widely reported to mediate diverse inflammatory processes. During the last decade, novel roles for IL-17 in skeletal homeostasis have been discovered indicating the potential importance of this cytokine in bone metabolism. This review will summarize and discuss the involvement of IL-17 during bone homeostasis in both physiologic and pathologic conditions. A better understanding of the role of IL-17 in skeletal systems warrants an advance in bone biology, as well as development of therapeutic strategies against bone-lytic diseases, such as rheumatoid arthritis and periodontitis.
Keywords
Bone metabolism; IL-17; Periodontitis; Rheumatoid arthritis;
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