The roles of FADD in extrinsic apoptosis and necroptosis
![]() ![]() |
Lee, Eun-Woo
(Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University)
Seo, Jin-Ho (Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University) Jeong, Man-Hyung (Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University) Lee, Sang-Sik (Department of Biomedical Engineering, Kwandong University) Song, Jae-Whan (Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University) |
1 | Chang, L., Kamata, H., Solinas, G., Luo, J. L., Maeda, S., Venuprasad, K., Liu, Y. C. and Karin, M. (2006) The E3 ubiquitin ligase itch couples JNK activation to TNFalphainduced cell death by inducing c-FLIP(L) turnover. Cell 124, 601-613. DOI ScienceOn |
2 | Panka, D. J., Mano, T., Suhara, T., Walsh, K. and Mier, J. W. (2001) Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells. J. Biol. Chem. 276, 6893-6896. DOI ScienceOn |
3 | Pennarun, B., Meijer, A., de Vries, E. G., Kleibeuker, J. H., Kruyt, F. and de Jong, S. (2010) Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Biochim. Biophys. Acta. 1805, 123-140. |
4 | Feig, C., Tchikov, V., Schutze, S. and Peter, M. E. (2007) Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling. EMBO J. 26, 221-231. DOI ScienceOn |
5 | Wagner, K. W., Punnoose, E. A., Januario, T., Lawrence, D. A., Pitti, R. M., Lancaster, K., Lee, D., von Goetz, M., Yee, S. F., Totpal, K., Huw, L., Katta, V., Cavet, G., Hymowitz, S. G., Amler, L. and Ashkenazi, A. (2007) Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat. Med. 13, 1070-1077. DOI ScienceOn |
6 | Kaunisto, A., Kochin, V., Asaoka, T., Mikhailov, A., Poukkula, M., Meinander, A. and Eriksson, J. E. (2009) PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability. Cell Death Differ. 16, 1215-1226. DOI ScienceOn |
7 | Chanvorachote, P., Nimmannit, U., Wang, L., Stehlik, C., Lu, B., Azad, N. and Rojanasakul, Y. (2005) Nitric oxide negatively regulates Fas CD95-induced apoptosis through inhibition of ubiquitin-proteasome-mediated degradation of FLICE inhibitory protein. J. Biol. Chem. 280, 42044-42050. DOI ScienceOn |
8 | Poukkula, M., Kaunisto, A., Hietakangas, V., Denessiouk, K., Katajamaki, T., Johnson, M. S., Sistonen, L. and Eriksson, J. E. (2005) Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail. J. Biol. Chem. 280, 27345-27355. DOI ScienceOn |
9 | Walsh, C. M., Wen, B. G., Chinnaiyan, A. M., O'Rourke, K., Dixit, V. M. and Hedrick, S. M. (1998) A role for FADD in T cell activation and development. Immunity 8, 439-449. DOI ScienceOn |
10 | Kabra, N. H., Kang, C., Hsing, L. C., Zhang, J. and Winoto, A. (2001) T cell-specific FADD-deficient mice: FADD is required for early T cell development. Proc. Natl. Acad. Sci. U.S.A. 98, 6307-6312. DOI ScienceOn |
11 | Osborn, S. L., Sohn, S. J. and Winoto, A. (2007) Constitutive phosphorylation mutation in Fas-associated death domain (FADD) results in early cell cycle defects. J. Biol. Chem. 282, 22786-22792. DOI ScienceOn |
12 | Imtiyaz, H. Z., Zhou, X., Zhang, H., Chen, D., Hu, T. and Zhang, J. (2009) The death domain of FADD is essential for embryogenesis, lymphocyte development, and proliferation. J. Biol. Chem. 284, 9917-9926. DOI ScienceOn |
13 | Osborn, S. L., Diehl, G., Han, S. J., Xue, L., Kurd, N., Hsieh, K., Cado, D., Robey, E. A. and Winoto, A. (2010) Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis. Proc. Natl. Acad. Sci. U.S.A. 107, 13034-13039. DOI ScienceOn |
14 | Bell, B. D., Leverrier, S., Weist, B. M., Newton, R. H., Arechiga, A. F., Luhrs, K. A., Morrissette, N. S. and Walsh, C. M. (2008) FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc. Natl. Acad. Sci. U.S.A. 105, 16677-16682. DOI ScienceOn |
15 | Meylan, E., Burns, K., Hofmann, K., Blancheteau, V., Martinon, F., Kelliher, M. and Tschopp, J. (2004) RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat. Immunol. 5, 503-507. DOI ScienceOn |
16 | Kaiser, W. J., Upton, J. W., Long, A. B., Livingston-Rosanoff, D., Daley-Bauer, L. P., Hakem, R., Caspary, T. and Mocarski, E. S. (2011) RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 471, 368-372. DOI ScienceOn |
17 | Ch'en, I. L., Tsau, J. S., Molkentin, J. D., Komatsu, M. and Hedrick, S. M. (2011) Mechanisms of necroptosis in T cells. J. Exp. Med. 208, 633-641. DOI ScienceOn |
18 | He, S., Liang, Y., Shao, F. and Wang, X. (2011) Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway. Proc. Natl. Acad. Sci. U.S.A. 108, 20054-20059. DOI |
19 | Upton, J. W., Kaiser, W. J. and Mocarski, E. S. (2012) DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host & Microbe 11, 290-297. DOI ScienceOn |
20 | Rebsamen, M., Heinz, L. X., Meylan, E., Michallet, M. C., Schroder, K., Hofmann, K., Vazquez, J., Benedict, C. A. and Tschopp, J. (2009) DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep. 10, 916-922. DOI ScienceOn |
21 | Feoktistova, M., Geserick, P., Kellert, B., Dimitrova, D. P., Langlais, C., Hupe, M., Cain, K., MacFarlane, M., Hacker, G. and Leverkus, M. (2011) cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 43, 449-463. DOI ScienceOn |
22 | Bodmer, J. L., Holler, N., Reynard, S., Vinciguerra, P., Schneider, P., Juo, P., Blenis, J. and Tschopp, J. (2000) TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat. Cell Biol. 2, 241-243. DOI ScienceOn |
23 | Tenev, T., Bianchi, K., Darding, M., Broemer, M., Langlais, C., Wallberg, F., Zachariou, A., Lopez, J., MacFarlane, M., Cain, K. and Meier, P. (2011) The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol. Cell 43, 432-448. DOI ScienceOn |
24 | Shen, H. M., Lin, Y., Choksi, S., Tran, J., Jin, T., Chang, L., Karin, M., Zhang, J. and Liu, Z. G. (2004) Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol. Cell Biol. 24, 5914-5922. DOI ScienceOn |
25 | Newton, K., Harris, A. W., Bath, M. L., Smith, K. G. and Strasser, A. (1998) A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J. 17, 706-718. DOI ScienceOn |
26 | Kischkel, F. C., Lawrence, D. A., Chuntharapai, A., Schow, P., Kim, K. J. and Ashkenazi, A. (2000) Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity 12, 611-620. DOI ScienceOn |
27 | Sprick, M. R., Weigand, M. A., Rieser, E., Rauch, C. T., Juo, P., Blenis, J., Krammer, P. H. and Walczak, H. (2000) FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity 12, 599-609. DOI ScienceOn |
28 | Irrinki, K. M., Mallilankaraman, K., Thapa, R. J., Chandramoorthy, H. C., Smith, F. J., Jog, N. R., Gandhirajan, R. K., Kelsen, S. G., Houser, S. R., May, M. J., Balachandran, S. and Madesh, M. (2011) Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis. Mol. Cell Biol. 31, 3745-3758. DOI ScienceOn |
29 | Jin, Z. and El-Deiry, W. S. (2006) Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis. Mol. Cell Biol. 26, 8136-8148. DOI ScienceOn |
30 | Oberst, A., Dillon, C. P., Weinlich, R., McCormick, L. L., Fitzgerald, P., Pop, C., Hakem, R., Salvesen, G. S. and Green, D. R. (2011) Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 471, 363-367. DOI ScienceOn |
31 | Vercammen, D., Vandenabeele, P., Beyaert, R., Declercq, W. and Fiers, W. (1997) Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells. Cytokine 9, 801-808. DOI ScienceOn |
32 | Vanlangenakker, N., Vanden Berghe, T. and Vandenabeele, P. (2012) Many stimuli pull the necrotic trigger, an overview. Cell Death Differ. 19, 75-86. DOI ScienceOn |
33 | Los, M., Mozoluk, M., Ferrari, D., Stepczynska, A., Stroh, C., Renz, A., Herceg, Z., Wang, Z. Q. and Schulze-Osthoff, K. (2002) Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol. Biol. Cell 13, 978-988. DOI ScienceOn |
34 | Benedetti, A., Comporti, M. and Esterbauer, H. (1980) Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids. Biochim. Biophys. Acta. 620, 281-296. DOI ScienceOn |
35 | Orrenius, S., Gogvadze, V. and Zhivotovsky, B. (2007) Mitochondrial oxidative stress: implications for cell death. Annu. Rev. Pharmacol. Toxicol. 47, 143-183. DOI ScienceOn |
36 | Won, J. S. and Singh, I. (2006) Sphingolipid signaling and redox regulation. Free Radic. Biol. Med. 40, 1875-1888. DOI ScienceOn |
37 | Kagedal, K., Zhao, M., Svensson, I. and Brunk, U. T. (2001) Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem. J. 359, 335-343. DOI |
38 | Yeh, W. C., Pompa, J. L., McCurrach, M. E., Shu, H. B., Elia, A. J., Shahinian, A., Ng, M., Wakeham, A., Khoo, W., Mitchell, K., El-Deiry, W. S., Lowe, S. W., Goeddel, D. V. and Mak, T. W. (1998) FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 279, 1954-1958. DOI ScienceOn |
39 | Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X. and Wang, X. (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148, 213-227. DOI ScienceOn |
40 | Wang, Z., Jiang, H., Chen, S., Du, F. and Wang, X. (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148, 228-243. DOI ScienceOn |
41 | Zhang, J., Cado, D., Chen, A., Kabra, N. H. and Winoto, A. (1998) Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 392, 296-300. DOI ScienceOn |
42 | Antosiewicz, J., Ziolkowski, W., Kaczor, J. J. and Herman-Antosiewicz, A. (2007) Tumor necrosis factor-alpha- induced reactive oxygen species formation is mediated by JNK1-dependent ferritin degradation and elevation of labile iron pool. Free Radic. Biol. Med. 43, 265-270. DOI ScienceOn |
43 | Xie, C., Zhang, N., Zhou, H., Li, J., Li, Q., Zarubin, T., Lin, S. C. and Han, J. (2005) Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor- induced death in L929 cells. Mol. Cell Biol. 25, 6673-6681. DOI ScienceOn |
44 | Murthy, C. R., Rama Rao, K. V., Bai, G. and Norenberg, M. D. (2001) Ammonia-induced production of free radicals in primary cultures of rat astrocytes. J. Neurosci. Res. 66, 282-288. DOI ScienceOn |
45 | Saelens, X., Festjens, N., Parthoens, E., Vanoverberghe, I., Kalai, M., van Kuppeveld, F. and Vandenabeele, P. (2005) Protein synthesis persists during necrotic cell death. J. Cell Biol. 168, 545-551. DOI ScienceOn |
46 | Van Herreweghe, F., Mao, J., Chaplen, F. W., Grooten, J., Gevaert, K., Vandekerckhove, J. and Vancompernolle, K. (2002) Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE. Proc. Natl. Acad. Sci. U.S.A. 99, 949-954. DOI ScienceOn |
47 | Albrecht, J. and Norenberg, M. D. (2006) Glutamine: a Trojan horse in ammonia neurotoxicity. Hepatology 44, 788-794. DOI ScienceOn |
48 | Soldani, C. and Scovassi, A. I. (2002) Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Apoptosis 7, 321-328. DOI ScienceOn |
49 | Sun, X. M., Butterworth, M., MacFarlane, M., Dubiel, W., Ciechanover, A. and Cohen, G. M. (2004) Caspase activation inhibits proteasome function during apoptosis. Mol. Cell 14, 81-93. DOI ScienceOn |
50 | Vanlangenakker, N., Bertrand, M. J., Bogaert, P., Vandenabeele, P. and Berghe, T. V. (2011) TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis. 2, e230. DOI ScienceOn |
51 | Micheau, O. and Tschopp, J. (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181-190. DOI ScienceOn |
52 | Degterev, A., Hitomi, J., Germscheid, M., Ch'en, I. L., Korkina, O., Teng, X., Abbott, D., Cuny, G. D., Yuan, C., Wagner, G., Hedrick, S. M., Gerber, S. A., Lugovskoy, A. and Yuan, J. (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat. Chem. Biol. 4, 313-321. DOI ScienceOn |
53 | Gunther, C., Martini, E., Wittkopf, N., Amann, K., Weigmann, B., Neumann, H., Waldner, M. J., Hedrick, S. M., Tenzer, S., Neurath, M. F. and Becker, C. (2011) Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis. Nature 477, 335-339. DOI ScienceOn |
54 | Duprez, L., Takahashi, N., Van Hauwermeiren, F., Vandendriessche, B., Goossens, V., Vanden Berghe, T., Declercq, W., Libert, C., Cauwels, A. and Vandenabeele, P. (2011) RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome. Immunity 35, 908-918. DOI ScienceOn |
55 | Vercammen, D., Beyaert, R., Denecker, G., Goossens, V., Van Loo, G., Declercq, W., Grooten, J., Fiers, W. and Vandenabeele, P. (1998) Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J. Exp. Med. 187, 1477-1485. DOI |
56 | Bohgaki, T., Mozo, J., Salmena, L., Matysiak-Zablocki, E., Bohgaki, M., Sanchez, O., Strasser, A., Hakem, A. and Hakem, R. (2011) Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice. J. Cell Biol. 195, 277-291. DOI ScienceOn |
57 | Schulze-Osthoff, K., Bakker, A. C., Vanhaesebroeck, B., Beyaert, R., Jacob, W. A. and Fiers, W. (1992) Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. J. Biol. Chem. 267, 5317-5323. |
58 | Upton, J. W., Kaiser, W. J. and Mocarski, E. S. (2010) Virus inhibition of RIP3-dependent necrosis. Cell Host & Microbe 7, 302-313. DOI ScienceOn |
59 | Kalai, M., Van Loo, G., Vanden Berghe, T., Meeus, A., Burm, W., Saelens, X. and Vandenabeele, P. (2002) Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA. Cell Death Differ. 9, 981-994. DOI ScienceOn |
60 | Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., Yang, H., Amigorena, S., Ryffel, B., Barrat, F. J., Saftig, P., Levi, F., Lidereau, R., Nogues, C., Mira, J. P., Chompret, A., Joulin, V., Clavel-Chapelon, F., Bourhis, J., Andre, F., Delaloge, S., Tursz, T., Kroemer, G. and Zitvogel, L. (2007) Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat. Med. 13, 1050-1059. DOI ScienceOn |
61 | Hacker, H. and Karin, M. (2006) Regulation and function of IKK and IKK-related kinases. Sci. STKE 2006, re13. DOI ScienceOn |
62 | Hitomi, J., Christofferson, D. E., Ng, A., Yao, J., Degterev, A., Xavier, R. J. and Yuan, J. (2008) Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 135, 1311-1323. DOI ScienceOn |
63 | Laukens, B., Jennewein, C., Schenk, B., Vanlangenakker, N., Schier, A., Cristofanon, S., Zobel, K., Deshayes, K., Vucic, D., Jeremias, I., Bertrand, M. J., Vandenabeele, P. and Fulda, S. (2011) Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor alpha-induced necroptosis. Neoplasia 13, 971-979. DOI |
64 | McComb, S., Cheung, H. H., Korneluk, R. G., Wang, S., Krishnan, L. and Sad, S. (2012) cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation. Cell Death Differ. (In press). |
65 | Moulin, M., Anderton, H., Voss, A. K., Thomas, T., Wong, W. W., Bankovacki, A., Feltham, R., Chau, D., Cook, W. D., Silke, J. and Vaux, D. L. (2012) IAPs limit activation of RIP kinases by TNF receptor 1 during development. EMBO J. 31, 1679-1691. DOI |
66 | Lin, Y., Choksi, S., Shen, H. M., Yang, Q. F., Hur, G. M., Kim, Y. S., Tran, J. H., Nedospasov, S. A. and Liu, Z. G. (2004) Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J. Biol. Chem. 279, 10822-10828. DOI ScienceOn |
67 | He, S., Wang, L., Miao, L., Wang, T., Du, F., Zhao, L. and Wang, X. (2009) Receptor interacting protein kinase- 3 determines cellular necrotic response to TNFalpha. Cell 137, 1100-1111. DOI ScienceOn |
68 | Vercammen, D., Brouckaert, G., Denecker, G., Van de Craen, M., Declercq, W., Fiers, W. and Vandenabeele, P. (1998) Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways. J. Exp. Med. 188, 919-930. DOI |
69 | Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A. and Yuan, J. (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat. Chem. Biol. 1, 112-119. DOI ScienceOn |
70 | Chan, F. K., Shisler, J., Bixby, J. G., Felices, M., Zheng, L., Appel, M., Orenstein, J., Moss, B. and Lenardo, M. J. (2003) A role for tumor necrosis factor receptor-2 and receptor- interacting protein in programmed necrosis and antiviral responses. J. Biol. Chem. 278, 51613-51621. DOI ScienceOn |
71 | Cho, Y. S., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M. and Chan, F. K. (2009) Phosphorylationdriven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137, 1112-1123. DOI ScienceOn |
72 | Zhang, D. W., Shao, J., Lin, J., Zhang, N., Lu, B. J., Lin, S. C., Dong, M. Q. and Han, J. (2009) RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325, 332-336. DOI ScienceOn |
73 | Ma, Y., Temkin, V., Liu, H. and Pope, R. M. (2005) NF-kappaB protects macrophages from lipopolysaccharideinduced cell death: the role of caspase 8 and receptor-interacting protein. J. Biol. Chem. 280, 41827-41834. DOI ScienceOn |
74 | Kim, Y., Suh, N., Sporn, M. and Reed, J. C. (2002) An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J. Biol. Chem. 277, 22320-22329. DOI ScienceOn |
75 | Varfolomeev, E. and Vucic, D. (2008) (Un)expected roles of c-IAPs in apoptotic and NFkappaB signaling pathways. Cell Cycle 7, 1511-1521. DOI |
76 | Xu, G., Tan, X., Wang, H., Sun, W., Shi, Y., Burlingame, S., Gu, X., Cao, G., Zhang, T., Qin, J. and Yang, J. (2010) Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1. J. Biol. Chem. 285, 969-978. DOI ScienceOn |
77 | Wang, L., Du, F. and Wang, X. (2008) TNF-alpha induces two distinct caspase-8 activation pathways. Cell 133, 693-703. DOI ScienceOn |
78 | Schutze, S., Tchikov, V. and Schneider-Brachert, W. (2008) Regulation of TNFR1 and CD95 signalling by receptor compartmentalization. Nat. Rev. Mol. Cell Biol. 9, 655-662. DOI ScienceOn |
79 | Vince, J. E., Wong, W. W., Khan, N., Feltham, R., Chau, D., Ahmed, A. U., Benetatos, C. A., Chunduru, S. K., Condon, S. M., McKinlay, M., Brink, R., Leverkus, M., Tergaonkar, V., Schneider, P., Callus, B. A., Koentgen, F., Vaux, D. L. and Silke, J. (2007) IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 131, 682-693. DOI ScienceOn |
80 | Ozturk, S., Schleich, K. and Lavrik, I. N. (2012) Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions. Exp. Cell Res. 318, 1324-1331. DOI ScienceOn |
81 | Yu, J. W. and Shi, Y. (2008) FLIP and the death effector domain family. Oncogene 27, 6216-6227. DOI ScienceOn |
82 | Micheau, O., Thome, M., Schneider, P., Holler, N., Tschopp, J., Nicholson, D. W., Briand, C. and Grutter, M. G. (2002) The long form of FLIP is an activator of caspase- 8 at the Fas death-inducing signaling complex. J. Biol. Chem. 277, 45162-45171. DOI ScienceOn |
83 | Boatright, K. M., Deis, C., Denault, J. B., Sutherlin, D. P. and Salvesen, G. S. (2004) Activation of caspases-8 and -10 by FLIP(L). Biochem. J. 382, 651-657. DOI ScienceOn |
84 | Feng, S., Yang, Y., Mei, Y., Ma, L., Zhu, D. E., Hoti, N., Castanares, M. and Wu, M. (2007) Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell Signal 19, 2056-2067. DOI ScienceOn |
85 | Wilson, N. S., Dixit, V. and Ashkenazi, A. (2009) Death receptor signal transducers: nodes of coordination in immune signaling networks. Nat. Immunol. 10, 348-355. DOI ScienceOn |
86 | Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J. L., Schneider, P., Seed, B. and Tschopp, J. (2000) Fas triggers an alternative, caspase- 8-independent cell death pathway using the kinase RIP as effector molecule. Nat. Immunol. 1, 489-495. DOI ScienceOn |
87 | Lin, Y., Devin, A., Rodriguez, Y. and Liu, Z. G. (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev. 13, 2514-2526. DOI ScienceOn |
88 | O'Donnell, M. A., Perez-Jimenez, E., Oberst, A., Ng, A., Massoumi, R., Xavier, R., Green, D. R. and Ting, A. T. (2011) Caspase 8 inhibits programmed necrosis by processing CYLD. Nat. Cell Biol. 13, 1437-1442. DOI ScienceOn |
89 | Kroemer, G., Galluzzi, L. and Brenner, C. (2007) Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 87, 99-163. DOI ScienceOn |
90 | Mahmood, Z. and Shukla, Y. (2010) Death receptors: targets for cancer therapy. Exp. Cell Res. 316, 887-899. DOI ScienceOn |
91 | Mc Guire, C., Beyaert, R. and van Loo, G. (2011) Death receptor signalling in central nervous system inflammation and demyelination. Trends Neurosci. 34, 619-628. DOI ScienceOn |
92 | French, L. E. and Tschopp, J. (2003) Protein-based therapeutic approaches targeting death receptors. Cell Death Differ. 10, 117-123. DOI ScienceOn |
93 | Wajant, H. (2003) Death receptors. Essays Biochem. 39, 53-71. |
94 | Liao, W., Xiao, Q., Tchikov, V., Fujita, K., Yang, W., Wincovitch, S., Garfield, S., Conze, D., El-Deiry, W. S., Schutze, S. and Srinivasula, S. M. (2008) CARP-2 is an endosome- associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation. Curr. Biol. 18, 641-649. DOI ScienceOn |
95 | Perez, D. and White, E. (2003) E1A sensitizes cells to tumor necrosis factor alpha by downregulating c-FLIP S. J Virol. 77, 2651-2662. DOI |
96 | Cursi, S., Rufini, A., Stagni, V., Condo, I., Matafora, V., Bachi, A., Bonifazi, A. P., Coppola, L., Superti-Furga, G., Testi, R. and Barila, D. (2006) Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J. 25, 1895-1905. DOI ScienceOn |
97 | McDonald, E. R., 3rd and El-Deiry, W. S. (2004) Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. Proc. Natl. Acad. Sci. U.S.A. 101, 6170-6175. DOI ScienceOn |
98 | Jesenberger, V. and Jentsch, S. (2002) Deadly encounter: ubiquitin meets apoptosis. Nat. Rev. Mol. Cell Biol. 3, 112-121. DOI ScienceOn |
99 | Lee, J. C. and Peter, M. E. (2003) Regulation of apoptosis by ubiquitination. Immunol. Rev. 193, 39-47. DOI ScienceOn |
100 | Lee, E. W., Kim, J. H., Ahn, Y. H., Seo, J., Ko, A., Jeong, M., Kim, S. J., Ro, J. Y., Park, K. M., Lee, H. W., Park, E. J., Chun, K. H. and Song, J. (2012) Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis. Nat. Commun. 3, 978. DOI ScienceOn |
101 | Laster, S. M., Wood, J. G. and Gooding, L. R. (1988) Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. J. Immunol. 141, 2629-2634. |
102 | Ea, C. K., Deng, L., Xia, Z. P., Pineda, G. and Chen, Z. J. (2006) Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell 22, 245-257. DOI ScienceOn |
103 | Symons, A., Beinke, S. and Ley, S. C. (2006) MAP kinase kinase kinases and innate immunity. Trends Immunol. 27, 40-48. DOI ScienceOn |
104 | Varfolomeev, E. E. and Ashkenazi, A. (2004) Tumor necrosis factor: an apoptosis JuNKie? Cell 116, 491-497. DOI ScienceOn |
105 | Bertrand, M. J., Milutinovic, S., Dickson, K. M., Ho, W. C., Boudreault, A., Durkin, J., Gillard, J. W., Jaquith, J. B., Morris, S. J. and Barker, P. A. (2008) cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 30, 689-700. DOI ScienceOn |
106 | Kanayama, A., Seth, R. B., Sun, L., Ea, C. K., Hong, M., Shaito, A., Chiu, Y. H., Deng, L. and Chen, Z. J. (2004) TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol. Cell 15, 535-548. DOI ScienceOn |
107 | Declercq, W., Vanden Berghe, T. and Vandenabeele, P. (2009) RIP kinases at the crossroads of cell death and survival. Cell 138, 229-232. DOI ScienceOn |
108 | Vandenabeele, P., Galluzzi, L., Vanden Berghe, T. and Kroemer, G. (2010) Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat. Rev. Mol. Cell Biol. 11, 700-714. DOI ScienceOn |
109 | Shembade, N., Ma, A. and Harhaj, E. W. (2010) Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science 327, 1135-1139. DOI ScienceOn |
110 | Enesa, K., Zakkar, M., Chaudhury, H., Luong le, A., Rawlinson, L., Mason, J. C., Haskard, D. O., Dean, J. L. and Evans, P. C. (2008) NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling. J. Biol. Chem. 283, 7036-7045. DOI ScienceOn |
111 | Tourneur, L., Delluc, S., Levy, V., Valensi, F., Radford- Weiss, I., Legrand, O., Vargaftig, J., Boix, C., Macintyre, E. A., Varet, B., Chiocchia, G. and Buzyn, A. (2004) Absence or low expression of fas-associated protein with death domain in acute myeloid leukemia cells predicts resistance to chemotherapy and poor outcome. Cancer Res. 64, 8101-8108. DOI ScienceOn |
112 | Kischkel, F. C., Hellbardt, S., Behrmann, I., Germer, M., Pawlita, M., Krammer, P. H. and Peter, M. E. (1995) Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 14, 5579-5588. |
113 | Chen, G., Bhojani, M. S., Heaford, A. C., Chang, D. C., Laxman, B., Thomas, D. G., Griffin, L. B., Yu, J., Coppola, J. M., Giordano, T. J., Lin, L., Adams, D., Orringer, M. B., Ross, B. D., Beer, D. G. and Rehemtulla, A. (2005) Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas. Proc. Natl. Acad. Sci. U.S.A. 102, 12507-12512. DOI ScienceOn |
114 | Tourneur, L., Mistou, S., Michiels, F. M., Devauchelle, V., Renia, L., Feunteun, J. and Chiocchia, G. (2003) Loss of FADD protein expression results in a biased Fas-signaling pathway and correlates with the development of tumoral status in thyroid follicular cells. Oncogene 22, 2795-2804. DOI ScienceOn |
115 | Bonnet, M. C., Preukschat, D., Welz, P. S., van Loo, G., Ermolaeva, M. A., Bloch, W., Haase, I. and Pasparakis, M. (2011) The adaptor protein fadd protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 35, 572-582. DOI ScienceOn |
116 | Lu, J. V., Weist, B. M., van Raam, B. J., Marro, B. S., Nguyen, L. V., Srinivas, P., Bell, B. D., Luhrs, K. A., Lane, T. E., Salvesen, G. S. and Walsh, C. M. (2011) Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc. Natl. Acad. Sci. U.S.A. 108, 15312-15317. DOI ScienceOn |
117 | Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K. M., Krammer, P. H. and Peter, M. E. (1998) Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17, 1675-1687. DOI ScienceOn |
118 | Schinske, K. A., Nyati, S., Khan, A. P., Williams, T. M., Johnson, T. D., Ross, B. D., Tomas, R. P. and Rehemtulla, A. (2011) A novel kinase inhibitor of FADD phosphorylation chemosensitizes through the inhibition of NF-kappaB. Mol. Cancer Ther. 10, 1807-1817. DOI |
119 | Bhojani, M. S., Chen, G., Ross, B. D., Beer, D. G. and Rehemtulla, A. (2005) Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer. Cell Cycle. 4, 1478-1481. DOI |
120 | Werner, M. H., Wu, C. and Walsh, C. M. (2006) Emerging roles for the death adaptor FADD in death receptor avidity and cell cycle regulation. Cell Cycle. 5, 2332-2338. DOI |
121 | Barnhart, B. C., Alappat, E. C. and Peter, M. E. (2003) The CD95 type I/type II model. Semin. Immunol. 15, 185-193. DOI ScienceOn |
122 | Yin, X. M., Wang, K., Gross, A., Zhao, Y., Zinkel, S., Klocke, B., Roth, K. A. and Korsmeyer, S. J. (1999) Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400, 886-891. DOI ScienceOn |
123 | Ozoren, N. and El-Deiry, W. S. (2002) Defining characteristics of Types I and II apoptotic cells in response to TRAIL. Neoplasia 4, 551-557. DOI ScienceOn |
124 | Willis, S. N. and Adams, J. M. (2005) Life in the balance: how BH3-only proteins induce apoptosis. Curr. Opin. Cell Biol. 17, 617-625. DOI ScienceOn |
125 | Johnstone, R. W., Frew, A. J. and Smyth, M. J. (2008) The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat. Rev. Cancer 8, 782-798. DOI ScienceOn |
126 | Verhagen, A. M., Ekert, P. G., Pakusch, M., Silke, J., Connolly, L. M., Reid, G. E., Moritz, R. L., Simpson, R. J. and Vaux, D. L. (2000) Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102, 43-53. DOI ScienceOn |
127 | Du, C., Fang, M., Li, Y., Li, L. and Wang, X. (2000) Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102, 33-42. DOI ScienceOn |
128 | Lavrik, I., Golks, A. and Krammer, P. H. (2005) Death receptor signaling. J. Cell Sci. 118, 265-267. DOI ScienceOn |
129 | Zhang, H., Zhou, X., McQuade, T., Li, J., Chan, F. K. and Zhang, J. (2011) Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 471, 373-376. DOI ScienceOn |
130 | Welz, P. S., Wullaert, A., Vlantis, K., Kondylis, V., Fernandez- Majada, V., Ermolaeva, M., Kirsch, P., Sterner-Kock, A., van Loo, G. and Pasparakis, M. (2011) FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 477, 330-334. DOI ScienceOn |
131 | Jang, M. S., Lee, S. J., Kim, C. J., Lee, C. W. and Kim, E. (2011) Phosphorylation by polo-like kinase 1 induces the tumor-suppressing activity of FADD. Oncogene 30, 471-481. DOI ScienceOn |
132 | Jang, M. S., Lee, S. J., Kang, N. S. and Kim, E. (2011) Cooperative phosphorylation of FADD by Aur-A and Plk1 in response to taxol triggers both apoptotic and necrotic cell death. Cancer Res. 71, 7207-7215. DOI ScienceOn |
133 | Alappat, E. C., Volkland, J. and Peter, M. E. (2003) Cell cycle effects by C-FADD depend on its C-terminal phosphorylation site. J. Biol. Chem. 278, 41585-41588. DOI ScienceOn |
134 | Rochat-Steiner, V., Becker, K., Micheau, O., Schneider, P., Burns, K. and Tschopp, J. (2000) FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation. J. Exp. Med. 192, 1165-1174. DOI |
135 | Scaffidi, C., Volkland, J., Blomberg, I., Hoffmann, I., Krammer, P. H. and Peter, M. E. (2000) Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase. J. Immunol. 164, 1236-1242. DOI |
136 | Schrijvers, M. L., Pattje, W. J., Slagter-Menkema, L., Mastik, M. F., Gibcus, J. H., Langendijk, J. A., van der Wal, J. E., van der Laan, B. F. and Schuuring, E. (2012) FADD expression as a prognosticator in early-stage glottic squamous cell carcinoma of the larynx treated primarily with radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 83, 1220-1226. DOI ScienceOn |
137 | Alappat, E. C., Feig, C., Boyerinas, B., Volkland, J., Samuels, M., Murmann, A. E., Thorburn, A., Kidd, V. J., Slaughter, C. A., Osborn, S. L., Winoto, A., Tang, W. J. and Peter, M. E. (2005) Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. Mol. Cell 19, 321-332. DOI ScienceOn |
138 | Tourneur, L. and Chiocchia, G. (2010) FADD: a regulator of life and death. Trends Immunol. 31, 260-269. DOI ScienceOn |
![]() |