[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5483/BMBRep.2011.44.8.497

The role of peroxidases in the pathogenesis of atherosclerosis

Park, Jong-Gil (Division of Life and Pharmaceutical Sciences, Ewha Womans University)
Oh, Goo-Taeg (College of Veterinary Medicine, Seoul National University)

Publication Information

BMB Reports / v.44, no.8, 2011 , pp. 497-505 More about this Journal

Abstract

Reactive oxygen species (ROS), which include superoxide anions and peroxides, induce oxidative stress, contributing to the initiation and progression of cardiovascular diseases involving atherosclerosis. The endogenous and exogenous factors hypercholesterolemia, hyperglycemia, hypertension, and shear stress induce various enzyme systems such as nicotinamide adenine dinucleotide (phosphate) oxidase, xanthine oxidase, and lipoxygenase in vascular and immune cells, which generate ROS. Besides inducing oxidative stress, ROS mediate signaling pathways involved in monocyte adhesion and infiltration, platelet activation, and smooth muscle cell migration. A number of antioxidant enzymes (e.g., superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins) regulate ROS in vascular and immune cells. Atherosclerosis results from a local imbalance between ROS production and these antioxidant enzymes. In this review, we will discuss 1) oxidative stress and atherosclerosis, 2) ROS-dependent atherogenic signaling in endothelial cells, macrophages, and vascular smooth muscle cells, 3) roles of peroxidases in atherosclerosis, and 4) antioxidant drugs and therapeutic perspectives.

Keywords

Atherosclerosis; Catalase; Glutathione peroxidase; Oxidative stress; Peroxidase; Peroxiredoxin; Reactive oxygen species;

Citations & Related Records

Times Cited By KSCI : 4 (Citation Analysis)
Times Cited By Web Of Science : 12 (Related Records In Web of Science)
Times Cited By SCOPUS : 4

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