CK2 phosphorylates AP-2α and increases its transcriptional activity
![]() ![]() |
Ren, Kaiqun
(Model Animal Research Center, MOE Key Laboratory of Model Animal for Disease Research, Medical School, Nanjing University)
Xiang, Shuanglin (Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Science, Hunan Normal University) He, Fangli (Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Science, Hunan Normal University) Zhang, Wenfeng (Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Science, Hunan Normal University) Ding, Xiaofeng (Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Science, Hunan Normal University) Wu, Yanyang (Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Science, Hunan Normal University) Yang, Liping (Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Science, Hunan Normal University) Zhou, Jianlin (Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Science, Hunan Normal University) Gao, Xiang (Model Animal Research Center, MOE Key Laboratory of Model Animal for Disease Research, Medical School, Nanjing University) Zhang, Jian (Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Science, Hunan Normal University) |
1 | Guerra, B. and Issinger, O. G. (1999) Protein kinase CK2 and its role in cellular proliferation, development and pathology. Electrophoresis 20, 391-408. DOI ScienceOn |
2 | Romieu-Mourez, R., Landesman-Bollag, E., Seldin, D. C. and Sonenshein, G. E. (2002) Protein kinase CK2 promotes aberrant activation of nuclear factor-kappaB, transformed phenotype, and survival of breast cancer cells. Cancer Res. 62, 6770-6778. |
3 | Klapper, L. N., Kirschbaum, M. H., Sela, M. and Yarden, Y. (2000) Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors. Adv. Cancer Res. 77, 25-79. |
4 | Pellikainen, J., Kataja, V., Ropponen, K., Kellokoski, J., Pietilainen, T., Bohm, J., Eskelinen, M. and Kosma, V. M. (2002) Reduced nuclear expression of transcription factor AP-2 associates with aggressive breast cancer. Clin. Cancer Res. 8, 3487-3495. |
5 | Pellikainen, J. M. and Kosma, V. M. (2007) Activator protein- 2 in carcinogenesis with a special reference to breast cancer--a mini review. Int. J. Cancer 120, 2061-2067. DOI ScienceOn |
6 | Apopa, P. L., He, X. and Ma, Q. (2008) Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells. J. Biochem. Mol. Toxicol. 22, 63-76. DOI ScienceOn |
7 | Sarno, S., Moro, S., Meggio, F., Zagotto, G., Dal Ben, D., Ghisellini, P., Battistutta, R., Zanotti, G. and Pinna, L. A. (2002) Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol. Ther. 93, 159-168. DOI ScienceOn |
8 | Sarno, S., Reddy, H., Meggio, F., Ruzzene, M., Davies, S. P., Donella-Deana, A., Shugar, D. and Pinna, L. A. (2001) Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase- 2'). FEBS Lett. 496, 44-48. DOI ScienceOn |
9 | Batsche, E., Muchardt, C., Behrens, J., Hurst, H. C. and Cremisi, C. (1998) RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2. Mol. Cell Biol. 18, 3647-3658. DOI |
10 | Williams, T. and Tjian, R. (1991) Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins. Science 251, 1067-1071. DOI |
11 | Li, M., Wang, Y., Hung, M. C. and Kannan, P. (2006) Inefficient proteasomal-degradation pathway stabilizes AP-2alpha and activates HER-2/neu gene in breast cancer. Int. J. Cancer 118, 802-811. DOI ScienceOn |
12 | Tapia, J. C., Torres, V. A., Rodriguez, D. A., Leyton, L. and Quest, A. F. (2006) Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/ lymphoid enhancer binding factor-dependent transcription. Proc. Natl. Acad. Sci. U.S.A. 103, 15079- 15084. DOI ScienceOn |
13 | Kim, Y. K., Lee, W. K., Jin, Y., Lee, K. J., Jeon, H. and Yu, Y. G. (2006) Doxorubicin binds to un-phosphorylated form of hNopp140 and reduces protein kinase CK2- dependent phosphorylation of hNopp140. J. Biochem. Mol. Biol. 39, 774-781. DOI |
14 | Canton, D. A., Zhang, C. and Litchfield, D. W. (2001) Assembly of protein kinase CK2: investigation of complex formation between catalytic and regulatory subunits using a zinc-finger-deficient mutant of CK2beta. Biochem. J. 358, 87-94. DOI |
15 | Niefind, K., Guerra, B., Ermakowa, I. and Issinger, O. G. (2001) Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme. Embo J. 20, 5320-5331. DOI ScienceOn |
16 | Romero-Oliva, F. and Allende, J. E. (2001) Protein p21(WAF1/CIP1) is phosphorylated by protein kinase CK2 in vitro and interacts with the amino terminal end of the CK2 beta subunit. J. Cell Biochem. 81, 445-452. DOI ScienceOn |
17 | Lebrin, F., Chambaz, E. M. and Bianchini, L. (2001) A role for protein kinase CK2 in cell proliferation: evidence using a kinase-inactive mutant of CK2 catalytic subunit alpha. Oncogene 20, 2010-2022. DOI |
18 | Litchfield, D. W. (2003) Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem. J. 369, 1-15. DOI ScienceOn |
19 | Lin, J. M., Kilman, V. L., Keegan, K., Paddock, B., Emery-Le, M., Rosbash, M. and Allada, R. (2002) A role for casein kinase 2alpha in the Drosophila circadian clock. Nature 420, 816-820. DOI ScienceOn |
20 | Barz, T., Ackermann, K., Dubois, G., Eils, R. and Pyerin, W. (2003) Genome-wide expression screens indicate a global role for protein kinase CK2 in chromatin remodeling. J. Cell Sci. 116, 1563-1577. DOI ScienceOn |
21 | Gotz, C., Bachmann, C. and Montenarh, M. (2007) Inhibition of protein kinase CK2 leads to a modulation of androgen receptor dependent transcription in prostate cancer cells. Prostate 67, 125-134. DOI ScienceOn |
22 | Decary, S., Decesse, J. T., Ogryzko, V., Reed, J. C., Naguibneva, I., Harel-Bellan, A. and Cremisi, C. E. (2002) The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2. Mol. Cell Biol. 22, 7877-7888. DOI |
23 | Campillos, M., Garcia, M. A., Valdivieso, F. and Vazquez, J. (2003) Transcriptional activation by AP-2alpha is modulated by the oncogene DEK. Nucleic Acids Res. 31, 1571-1575. DOI ScienceOn |
24 | Ding, X., Fan, C., Zhou, J., Zhong, Y., Liu, R., Ren, K., Hu, X., Luo, C., Xiao, S., Wang, Y., Feng, D. and Zhang, J. (2006) GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation. Nucleic Acids Res. 34, 2570-2578. DOI ScienceOn |
25 | Garcia, M. A., Campillos, M., Marina, A., Valdivieso, F. and Vazquez, J. (1999) Transcription factor AP-2 activity is modulated by protein kinase A-mediated phosphorylation. FEBS Lett. 444, 27-31. DOI ScienceOn |
26 | Saksena, S., Dwivedi, A., Gill, R. K., Singla, A., Alrefai, W. A., Malakooti, J., Ramaswamy, K. and Dudeja, P. K. (2009) PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G275-283. DOI |
27 | Imagawa, M., Chiu, R. and Karin, M. (1987) Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell 51, 251-260. DOI ScienceOn |
28 | Iwamoto, N., Abe-Dohmae, S., Lu, R. and Yokoyama, S. (2008) Involvement of protein kinase D in phosphorylation and increase of DNA binding of activator protein 2 alpha to downregulate ATP-binding cassette transporter A1. Arterioscler. Thromb. Vasc. Biol. 28, 2282-2287. DOI ScienceOn |
29 | Gietz, R. D., Graham, K. C. and Litchfield, D. W. (1995) Interactions between the subunits of casein kinase II. J. Biol. Chem. 270, 13017-13021. DOI ScienceOn |
30 | Bosher, J. M., Totty, N. F., Hsuan, J. J., Williams, T. and Hurst, H. C. (1996) A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma. Oncogene 13, 1701-1707. |
31 | Cheng, C., Ying, K., Xu, M., Zhao, W., Zhou, Z., Huang, Y., Wang, W., Xu, J., Zeng, L. and Xie, Y. and Mao, Y. (2002) Cloning and characterization of a novel human transcription factor AP-2 beta like gene (TFAP2BL1). Int. J. Biochem. Cell Biol. 34, 78-86. DOI ScienceOn |
32 | Tummala, R., Romano, R. A., Fuchs, E. and Sinha, S. (2003) Molecular cloning and characterization of AP-2 epsilon, a fifth member of the AP-2 family. Gene 321, 93-102. DOI ScienceOn |
33 | Hilger-Eversheim, K., Moser, M., Schorle, H. and Buettner, R. (2000) Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control. Gene 260, 1-12. DOI ScienceOn |
34 | Feng, W. and Williams, T. (2003) Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb. Mol. Cell Neurosci. 24, 460-475. DOI ScienceOn |
35 | Wang, H. V., Vaupel, K., Buettner, R., Bosserhoff, A. K. and Moser, M. (2004) Identification and embryonic expression of a new AP-2 transcription factor, AP-2 epsilon. Dev. Dyn. 231, 128-135. DOI ScienceOn |
36 | Wu, F. and Lee, A. S. (2001) YY1 as a regulator of replication- dependent hamster histone H3.2 promoter and an interactive partner of AP-2. J. Biol. Chem. 276, 28-34. DOI |
![]() |