Browse > Article
http://dx.doi.org/10.5483/BMBRep.2011.44.7.478

Downregulation of Foxe1 by HR suppresses Msx1 expression in the hair follicles of HrHp mice  

Choi, Jee-Hyun (Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea)
Kim, Byong-Kyu (Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea)
Kim, Jeong-Ki (Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea)
Lee, Hwa-Young (Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea)
Park, Jong-Keun (Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea)
KimYoon, Sung-Joo (Department of Biomedical Sciences, Research Institute of Molecular Genetics, College of Medicine, The Catholic University of Korea)
Publication Information
BMB Reports / v.44, no.7, 2011 , pp. 478-483 More about this Journal
Abstract
Hairless (HR), a transcriptional cofactor, is highly expressed in the skin and brain. To characterize the effects of HR expression in the skin, we examined its capacity for transcriptional regulation of its target genes in mouse skin and keratinocytes. We found that Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. In turn, Msx1 expression was downregulated contingent on Foxe1 downregulation in skin and keratinocytes. We also found that expression of Sfrp1 was also correlated with that of Foxe1. Further investigation of the mechanisms involved in the transcriptional regulation of these genes will facilitate our understanding of the relationship among genes involved in hair follicle morphogenesis and cycling.
Keywords
Foxe1; Hair follicle; Hairless; Msx1; Sfrp1;
Citations & Related Records

Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
연도 인용수 순위
1 Reddy, S., Andl, T., Bagasra, A., Lu, M. M., Epstein, D. J., Morrisey, E. E. and Millar, S. E. (2001) Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech. Dev. 107, 69-82.   DOI   ScienceOn
2 Iseki, S., Araga, A., Ohuchi, H., Nohno, T., Yoshioka, H., Hayashi, F. and Noji, S. (1996) Sonic hedgehog is expressed in epithelial cells during development of whisker, hair, and tooth. Biochem. Biophys. Res. Commun. 218, 688-693.   DOI   ScienceOn
3 Chiang, C., Swan, R. Z., Grachtchouk, M., Bolinger, M., Litingtung, Y., Robertson, E. K., Cooper, M. K., Gaffield, W., Westphal, H., Beachy, P. A. and Dlugosz, A. A. (1999) Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev. Biol. 205, 1-9.   DOI   ScienceOn
4 Livak, K. J. and Schmittgen, T. D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-408.   DOI   ScienceOn
5 Nam, Y., Kim, J. K., Cha, D. S., Cho, J. W., Cho, K. H., Yoon, S., Yoon, J. B., Oh, Y. S., Suh, J. G., Han, S. S., Song, C. W. and Yoon, S. K. (2006) A novel missense mutation in the mouse hairless gene causes irreversible hair loss: genetic and molecular analyses of Hr m1Enu. Genomics 87, 520-526.   DOI   ScienceOn
6 Flagg, A. E., Earley, J. U. and Svensson, E. C. (2007) FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Dev. Biol. 304, 308-316.   DOI   ScienceOn
7 Eichberger, T., Regl, G., Ikram, M. S., Neill, G. W., Philpott, M. P., Aberger, F. and Frischauf, A. M. (2004) FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma. J. Invest. Dermatol. 122, 1180-1187.   DOI   ScienceOn
8 Brancaccio, A. (2004) Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis. Hum. Mol. Genet. 13, 2595- 2606.   DOI   ScienceOn
9 Venza, I., Visalli, M., Parrillo, L., De Felice, M., Teti, D. and Venza, M. (2010) Msx1 and TGF-3 are novel target genes functionally regulated by FOXE1. Hum. Mol. Genet. 20, 1016-1025.
10 Rendl, M., Lewis, L. and Fuchs, E. (2005) Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol. 3, e331.   DOI   ScienceOn
11 Revet, I., Huizenga, G., Koster, J., Volckmann, R., van Sluis, P., Versteeg, R. and Geerts, D. (2010) Msx1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3. Cancer Lett. 289, 195-207.   DOI   ScienceOn
12 Liu, F., Chu, E. Y., Watt, B., Zhang, Y., Gallant, N. M., Andl, T., Yang, S. H., Lu, M. M., Piccolo, S., Schmidt- Ullrich, R., Taketo, M. M., Morrisey, E. E., Atit, R., Dlugosz, A. A. and Millar, S. E. (2008) Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev. Biol. 313, 210-224.   DOI   ScienceOn
13 Iwatsuki, K., Liu, H. X., Gronder, A., Singer, M. A., Lane, T. F., Grosschedl, R., Mistretta, C. M. and Margolskee, R. F. (2007) Wnt signaling interacts with Shh to regulate taste papilla development. Proc. Natl. Acad. Sci. U. S. A. 104, 2253-2258.   DOI   ScienceOn
14 Li, C., Xiao, J., Hormi, K., Borok, Z. and Minoo, P. (2002) Wnt5a participates in distal lung morphogenesis. Dev. Biol. 248, 68-81.   DOI   ScienceOn
15 St-Jacques, B., Dassule, H. R., Karavanova, I., Botchkarev, V. A., Li, J., Danielian, P. S., McMahon, J. A., Lewis, P. M., Paus, R. and McMahon, A. P. (1998) Sonic hedgehog signaling is essential for hair development. Curr. Biol. 8, 1058-1068.   DOI   ScienceOn
16 Beaudoin, G. M., 3rd, Sisk, J. M., Coulombe, P. A. and Thompson, C. C. (2005) Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc. Natl. Acad. Sci. U. S. A. 102, 14653-14658.   DOI   ScienceOn
17 Hsieh, J. C., Slater, S. A., Whitfield, G. K., Dawson, J. L., Hsieh, G., Sheedy, C., Haussler, C. A. and Haussler, M. R. (2010) Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle. J. Cell. Biochem. 110, 671-686.   DOI   ScienceOn
18 Kim, B. K., Baek, I. C., Lee, H. Y., Kim, J. K., Song, H. H. and Yoon, S. K. (2010) Gene expression profile of the skin in the 'hairpoor' (HrHp) mice by microarray analysis. BMC Genomics 11, 640.   DOI   ScienceOn
19 Moraitis, A. N., Giguere, V. and Thompson, C. C. (2002) Novel mechanism of nuclear receptor corepressor interaction dictated by activation function 2 helix determinants. Mol. Cell. Biol. 22, 6831-6841.   DOI
20 Potter, G. B., Beaudoin, G. M., 3rd, DeRenzo, C. L., Zarach, J. M., Chen, S. H. and Thompson, C. C. (2001) The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Genes Dev. 15, 2687-2701.   DOI   ScienceOn
21 Carlsson, P. (2002) Forkhead transcription factors: key players in development and metabolism. Dev. Biol. 250, 1-23.   DOI   ScienceOn
22 Mecklenburg, L., Nakamura, M., Sundberg, J. P. and Paus, R. (2001) The nude mouse skin phenotype: the role of Foxn1 in hair follicle development and cycling. Exp. Mol. Pathol. 71, 171-178.   DOI   ScienceOn
23 Lee, D., Prowse, D. M. and Brissette, J. L. (1999) Association between mouse nude gene expression and the initiation of epithelial terminal differentiation. Dev. Biol. 208, 362-374.
24 Perrone, L. (2000) The thyroid transcription factor 2 (TTF-2) is a promoter-specific DNA-binding independent transcriptional repressor. Biochem. Biophys. Res. Commun. 275, 203-208.   DOI   ScienceOn
25 Schmidt-Ullrich, R. and Paus, R. (2005) Molecular principles of hair follicle induction and morphogenesis. Bioessays. 27, 247-261.   DOI   ScienceOn
26 Paus, R. and Foitzik, K. (2004) In search of the "hair cycle clock": a guided tour. Differentiation 72, 489-511.   DOI   ScienceOn
27 Stenn, K. S. and Paus, R. (2001) Controls of hair follicle cycling. Physiol. Rev. 81, 449-494.   DOI
28 Millar, S. E. (2002) Molecular mechanisms regulating hair follicle development. J. Invest. Dermatol. 118, 216-225.   DOI   ScienceOn
29 Mikkola, M. L. (2007) Genetic basis of skin appendage development. Semin. Cell. Dev. Biol. 18, 225-236.   DOI   ScienceOn
30 Shimomura, Y. and Christiano, A. M. (2010) Biology and genetics of hair. Annu. Rev. Genomics Hum. Genet. 11, 109-132.   DOI   ScienceOn
31 Baek, I. C., Kim, J. K., Cho, K. H., Cha, D. S., Cho, J. W., Park, J. K., Song, C. W. and Yoon, S. K. (2009) A novel mutation in Hr causes abnormal hair follicle morphogenesis in hairpoor mouse, an animal model for Marie Unna Hereditary Hypotrichosis. Mamm. Genome 20, 350-358.   DOI
32 Kim, J. K., Kim, E., Baek, I. C., Kim, B. K., Cho, A. R., Kim, T. Y., Song, C. W., Seong, J. K., Yoon, J. B., Stenn, K. S., Parimoo, S. and Yoon, S. K. (2010) Overexpression of Hr links excessive induction of Wnt signaling to Marie Unna hereditary hypotrichosis. Hum. Mol. Genet. 19, 445-453.   DOI   ScienceOn