[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5483/BMBRep.2011.44.7.452

Estrogen receptor β stimulates Egr-1 transcription via MEK1/Erk/Elk-1 cascade in C6 glioma cells

Kim, Ji-Ha (Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University)
Jeong, Il-Yeup (Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University)
Lim, Yoong-Ho (Division of Bioscience and Biotechnology, BMIC)
Lee, Young-Han (Department of Biomedical Science and Technology, SMART Institute of Advanced Biomedical Science)
Shin, Soon-Young (Department of Biomedical Science and Technology, SMART Institute of Advanced Biomedical Science)

Publication Information

BMB Reports / v.44, no.7, 2011 , pp. 452-457 More about this Journal

Abstract

The Egr-1 is an immediate early response gene encoding a transcription factor that functions in the regulation of cell growth, differentiation, and apoptosis. Estrogen has diverse physiological effects, including cellular proliferation and neuroprotection against brain injury. There are two types of estrogen receptors (ERs), $ER{\alpha}$ and $ER{\beta}$ . $ER{\alpha}$ -induced Egr-1 expression has been extensively studied; however, the role of $ER{\beta}$ is yet not known. In the present study, we investigated whether or not $ER{\beta}$ induces Egr-1 expression in C6 rat glioma cells, which express $ER{\beta}$ but not $ER{\alpha}$ . Our results show that $ER{\beta}$ promoted up-regulation of Egr-1 expression via a non-genomic mechanism involving the Raf/MEK1/Erk/Elk-1 signaling cascade.

Keywords

C6 glioma; Egr-1; Estrogen receptor ${\beta}$ ; MAPK; $17{\beta}$ -estradiol;

Citations & Related Records

Times Cited By KSCI : 1 (Citation Analysis)
Times Cited By Web Of Science : 0 (Related Records In Web of Science)
Times Cited By SCOPUS : 0

Reference
Cited By KSCI

1	Migliaccio, A., Castoria, G., Di Domenico, M., de Falco, A., Bilancio, A., Lombardi, M., Barone, M. V., Ametrano, D., Zannini, M. S., Abbondanza, C. and Auricchio, F. (2000) Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation. EMBO J. 19, 5406-5417. DOI ScienceOn
2	Sukhatme, V. P., Cao, X. M., Chang, L. C., Tsai-Morris, C. H., Stamenkovich, D., Ferreira, P. C., Cohen, D. R., Edwards, S. A., Shows, T. B., Curran, T., Le Beau, M. M. and Adamson, E. D. (1988) A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 53, 37-43. DOI ScienceOn
3	Edwards, S. A., Darland, T., Sosnowski, R., Samuels, M. and Adamson, E. D. (1991) The transcription factor, Egr-1, is rapidly modulated in response to retinoic acid in P19 embryonal carcinoma cells. Dev. Biol. 148, 165-173. DOI ScienceOn
4	Liu, C., Rangnekar, V. M., Adamson, E. and Mercola, D. (1998) Suppression of growth and transformation and induction of apoptosis by EGR-1. Cancer Gene Ther. 5, 3-28.
5	Aicher, W. K., Sakamoto, K. M., Hack, A. and Eibel, H. (1999) Analysis of functional elements in the human Egr-1 gene promoter. Rheumatol. Int. 18, 207-214. DOI
6	Schwachtgen, J. L., Houston, P., Campbell, C., Sukhatme, V. and Braddock, M. (1998) Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway. J. Clin. Invest. 101, 2540-2549. DOI ScienceOn
7	Treisman, R. (1994) Ternary complex factors: growth factor regulated transcriptional activators. Curr. Opin. Genet. Dev. 4, 96-101. DOI ScienceOn
8	Sharrocks, A. D. (2002) Complexities in ETS-domain transcription factor function and regulation: lessons from the TCF (ternary complex factor) subfamily. The Colworth Medal Lecture. Biochem. Soc. Trans. 30, 1-9. DOI
9	de Jager, T., Pelzer, T., Muller-Botz, S., Imam, A., Muck, J. and Neyses, L. (2001) Mechanisms of estrogen receptor action in the myocardium. Rapid gene activation via the ERK1/2 pathway and serum response elements. J. Biol. Chem. 276, 27873-27880. DOI ScienceOn
10	Pratt, M. A., Satkunaratnam, A. and Novosad, D. M. (1998) Estrogen activates raf-1 kinase and induces expression of Egr-1 in MCF-7 breast cancer cells. Mol. Cell. Biochem. 189, 119-125. DOI ScienceOn
11	Sur, P., Sribnick, E. A., Wingrave, J. M., Nowak, M. W., Ray, S. K. and Banik, N. L. (2003) Estrogen attenuates oxidative stress-induced apoptosis in C6 glial cells. Brain Res. 971, 178-188. DOI ScienceOn
12	Tremblay, G. B., Tremblay, A., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Labrie, F. and Giguere, V. (1997) Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol. Endocrinol. 11, 353-365. DOI ScienceOn
13	Ling, Y., Lakey, J. H., Roberts, C. E. and Sharrocks, A. D. (1997) Molecular characterization of the B-box protein- protein interaction motif of the ETS-domain transcription factor Elk-1. EMBO J. 16, 2431-2440. DOI ScienceOn
14	McEwen, B. S. and Alves, S. E. (1999) Estrogen actions in the central nervous system. Endocr. Rev. 20, 279-307. DOI ScienceOn
15	Schratt, G., Weinhold, B., Lundberg, A. S., Schuck, S., Berger, J., Schwarz, H., Weinberg, R. A., Ruther, U. and Nordheim, A. (2001) Serum response factor is required for immediate-early gene activation yet is dispensable for proliferation of embryonic stem cells. Mol. Cell. Biol. 21, 2933-2943. DOI ScienceOn
16	Watson, D. K., Robinson, L., Hodge, D. R., Kola, I., Papas, T. S. and Seth, A. (1997) FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements. Oncogene 14, 213-221. DOI
17	Razandi, M., Pedram, A., Greene, G. L. and Levin, E. R. (1999) Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells. Mol. Endocrinol. 13, 307-319. DOI ScienceOn
18	Czlonkowska, A., Ciesielska, A. and Joniec, I. (2003) Influence of estrogens on neurodegenerative processes. Med. Sci. Monit. 9, RA247-256.
19	Song, R. X., Zhang, Z. and Santen, R. J. (2005) Estrogen rapid action via protein complex formation involving ERalpha and Src. Trends Endocrinol. Metab. 16, 347-353. DOI ScienceOn
20	Mosselman, S., Polman, J. and Dijkema, R. (1996) ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett. 392, 49-53. DOI ScienceOn
21	Milbrandt, J. (1987) A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 238, 797-799. DOI
22	Duan, R., Xie, W., Burghardt, R. C. and Safe, S. (2001) Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. J. Biol. Chem. 276, 11590-11598. DOI ScienceOn
23	Chen, C. C., Lee, W. R. and Safe, S. (2004) Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen- activated protein kinase-dependent phosphorylation of ELK-1. J. Cell. Biochem. 93, 1063-1074. DOI ScienceOn
24	Shin, S. Y., Kim, C. G., Kim, S. H., Kim, Y. S., Lim, Y. and Lee, Y. H. (2010) Chlorpromazine activates p21Waf1/ Cip1 gene transcription via early growth response-1 (Egr-1) in C6 glioma cells. Exp. Mol. Med. 42, 395-405. DOI ScienceOn
25	Guha, M., O'Connell, M. A., Pawlinski, R., Hollis, A., McGovern, P., Yan, S. F., Stern, D. and Mackman, N. (2001) Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression. Blood 98, 1429-1439. DOI
26	Kim, C. G., Choi, B. H., Son, S. W., Yi, S. J., Shin, S. Y. and Lee, Y. H. (2007) Tamoxifen-induced activation of p21Waf1/Cip1 gene transcription is mediated by Early Growth Response-1 protein through the JNK and p38 MAP kinase/Elk-1 cascades in MDA-MB-361 breast carcinoma cells. Cell Signal 19, 1290-1300. DOI ScienceOn

2	Min Ho Han. (2013) Toxicology Letters Sanguinarine induces apoptosis in human colorectal cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial dysfunction / 220 (2) , 157
	Amanda A. Krentzel. (2015) Frontiers in Neuroendocrinology Sex differences and rapid estrogen signaling: A look at songbird audition / 38 , 37
	Weiren Huang. (2015) BioMed Research International Roles of ERβand GPR30 in Proliferative Response of Human Bladder Cancer Cell to Estrogen / 2015 , 1
2	Soon Young Shin. (2013) BMB Reports Egr-1 regulates the transcription of the BRCA1 gene by etoposide / 46 (2) , 92
5	Min Ho Han. (2013) PLoS ONE Apoptosis Induction of Human Bladder Cancer Cells by Sanguinarine through Reactive Oxygen Species-Mediated Up-Regulation of Early Growth Response Gene-1 / 8 (5) , e63425
2	Zahra Moinfar. (2016) PLOS ONE Estradiol Receptors Regulate Differential Connexin 43 Expression in F98 and C6 Glioma Cell Lines / 11 (2) , e0150007
	Hye-Ryun Kim. (2014) Reproductive Toxicology Egr1 is rapidly and transiently induced by estrogen and bisphenol A via activation of nuclear estrogen receptor-dependent ERK1/2 pathway in the uterus / 50 , 60
3	F. N. Cavalcanti. (2015) Journal of Molecular Endocrinology Estrogen receptor ESR1 mediates activation of ERK1/2, CREB, and ELK1 in the corpus of the epididymis / 54 (3) , 339
13	Gabriel L. Galea. (2013) Journal of Biological Chemistry Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt AntagonistSostIs Mediated by Estrogen Receptor β / 288 (13) , 9035
6	J. M. Moreno-Moya. (2014) MHR: Basic science of reproductive medicine The transcriptomic and proteomic effects of ectopic overexpression of miR-30d in human endometrial epithelial cells / 20 (6) , 550
1	Minchenko Do. (2017) Endocrine Regulations Hypoxic regulation of the expression of genes encoded estrogen related proteins in U87 glioma cells: eff ect of IRE1 inhibition / 51 (1)
2045-4538	(2018) Toxicology Research Roles of ERK1/2 and PI3K/AKT signaling pathways in mitochondria-mediated apoptosis in testes of hypothyroid rats / (2045-4538)