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http://dx.doi.org/10.5483/BMBRep.2011.44.7.435

Evaluating the progenitor cells of ovarian cancer: analysis of current animal models  

King, Shelby M. (Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago)
Burdette, Joanna E. (Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago)
Publication Information
BMB Reports / v.44, no.7, 2011 , pp. 435-445 More about this Journal
Abstract
Serous ovarian cancer is one of the most lethal gynecological malignancies. Progress on effective diagnostics and therapeutics for this disease are hampered by ambiguity as to the cellular origins of this histotype of ovarian cancer, as well as limited suitable animal models to analyze early stages of disease. In this report, we will review current animal models with respect to the two proposed progenitor cells for serous ovarian cancer, the ovarian surface epithelium and the fallopian tube epithelium.
Keywords
Animal model; Fallopian tube epithelium; Ovarian surface epithelium; Ovulation; Serous ovarian cancer;
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