| 1 |
Lee, Y. R., Park, J., Yu, H. N., Kim, J. S., Youn, H. J. and Jung, S. H. (2005) Up-regulation of PI3K/Akt signaling by 17beta-estradiol through activation of estrogen receptor- alpha, but not estrogen receptor-beta, and stimulates cell growth in breast cancer cells. Biochem. Biophys. Res. Commun. 336, 1221-1226.
DOI
ScienceOn
|
| 2 |
Rockhill, B., Spiegelman, D., Byrne, C., Hunter, D. J. and Colditz, G. A. (2001) Validation of the Gail et al. model of breast cancer risk prediction and implications for chemoprevention. J. Natl. Cancer Inst. 93, 358-366.
DOI
ScienceOn
|
| 3 |
Cavalieri, E. L., Stack, D. E., Devanesan, P. D., Todorovic, R., Dwivedy, I., Higginbotham, S., Johansson, S. L., Patil, K. D., Gross, M. L., Gooden, J. K., Ramanathan, R., Cerny, R. L. and Rogan, E. G. (1997) Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. Proc. Natl. Acad. Sci. U. S. A. 94, 10937-10942.
DOI
|
| 4 |
Yager, J. D. and Liehr, J. G. (1996) Molecular mechanisms of estrogen carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 36, 203-232.
DOI
ScienceOn
|
| 5 |
Parl, F. F., Dawling, S., Roodi, N. and Crooke, P. S. (2009) Estrogen metabolism and breast cancer: a risk model. Ann. N. Y. Acad. Sci. 1155, 68-75.
DOI
ScienceOn
|
| 6 |
Bocchinfuso, W. P., Hively, W. P., Couse, J. F., Varmus, H. E. and Korach, K. S. (1999) A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha. Cancer Res. 59, 1869-1876.
|
| 7 |
Roy, D., Cai, Q., Felty, Q. and Narayan, S. (2007) Estrogen-induced generation of reactive oxygen and nitrogen species, gene damage, and estrogen-dependent cancers. J. Toxicol. Environ. Health B. Crit. Rev. 10, 235-257.
DOI
ScienceOn
|
| 8 |
Foster, J. S., Henley, D. C., Bukovsky, A., Seth, P. and Wimalasena, J. (2001) Multifaceted regulation of cell cycle progression by estrogen: regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 function. Mol. Cell. Biol. 21, 794-810.
DOI
ScienceOn
|
| 9 |
Cui, Y., Parra, I., Zhang, M., Hilsenbeck, S. G., Tsimelzon, A., Furukawa, T., Horii, A., Zhang, Z. Y., Nicholson, R. I. and Fuqua, S. A. (2006) Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance. Cancer Res. 66, 5950-5959.
DOI
ScienceOn
|
| 10 |
Weinstein-Oppenheimer, C. R., Burrows, C., Steelman, L. S. and McCubrey, J. A. (2002) The effects of beta-estradiol on Raf activity, cell cycle progression and growth factor synthesis in the MCF-7 breast cancer cell line. Cancer Biol. Ther. 1, 256-262.
DOI
|
| 11 |
Adler, V., Yin, Z., Fuchs, S. Y., Benezra, M., Rosario, L., Tew, K. D., Pincus, M. R., Sardana, M., Henderson, C. J., Wolf, C. R., Davis, R. J. and Ronai, Z. (1999) Regulation of JNK signaling by GSTp. EMBO J. 18, 1321-1334.
DOI
ScienceOn
|
| 12 |
Kar, S., Wang, M., Yao, W., Michejda, C. J. and Carr, B. I. (2006) PM-20, a novel inhibitor of Cdc25A, induces extracellular signal-regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo. Mol. Cancer Ther. 5, 1511-1519.
|
| 13 |
Zhang, F., Swanson, S. M., van Breemen, R. B., Liu, X., Yang, Y., Gu, C. and Bolton, J. L. (2001) Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases. Chem. Res. Toxicol. 14, 1654-1659.
DOI
ScienceOn
|
| 14 |
Banerjee, S., Saxena, N., Sengupta, K. and Banerjee, S. K. (2003) 17alpha-estradiol-induced VEGF-A expression in rat pituitary tumor cells is mediated through ER independent but PI3K-Akt dependent signaling pathway. Biochem. Biophys. Res. Commun. 300, 209-215.
DOI
ScienceOn
|
| 15 |
Liu, X., Yao, J., Pisha, E., Yang, Y., Hua, Y., van Breemen, R. B. and Bolton, J. L. (2002) Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alpha. Chem. Res. Toxicol. 15, 512-519.
DOI
ScienceOn
|
| 16 |
Chen, Y., Liu, X., Pisha, E., Constantinou, A. I., Hua, Y., Shen, L., van Breemen, R. B., Elguindi, E. C., Blond, S. Y., Zhang, F. and Bolton, J. L. (2000) A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines. Chem. Res. Toxicol. 13, 342-350.
DOI
ScienceOn
|
| 17 |
Okahashi, Y., Iwamoto, T., Suzuki, N., Shibutani, S., Sugiura, S., Itoh, S., Nishiwaki, T., Ueno, S. and Mori, T. (2010) Quantitative detection of 4-hydroxyequilenin- DNA adducts in mammalian cells using an immunoassay with a novel monoclonal antibody. Nucleic Acids Res. 38, e133.
DOI
|
| 18 |
Ozcagli, E., Sardas, S. and Biri, A. (2005) Assessment of DNA damage in postmenopausal women under hormone replacement therapy. Maturitas 51, 280-285.
DOI
ScienceOn
|
| 19 |
Kamata, H. and Hirata, H. (1999) Redox regulation of cellular signalling. Cell Signal. 11, 1-14.
DOI
ScienceOn
|
| 20 |
Sauer, H., Wartenberg, M. and Hescheler, J. (2001) Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol. Biochem. 11, 173-186.
DOI
ScienceOn
|
| 21 |
Cavalieri, E., Chakravarti, D., Guttenplan, J., Hart, E., Ingle, J., Jankowiak, R., Muti, P., Rogan, E., Russo, J., Santen, R. and Sutter, T. (2006) Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention. Biochim. Biophys. Acta 1766, 63-78.
|
| 22 |
Circu, M. L. and Aw, T. Y. (2010) Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic. Biol. Med. 48, 749-762.
DOI
ScienceOn
|
| 23 |
Surh, Y.-J., Kundu, J. K., Na, H.-K. and Lee, J.-S. (2005) Redox-Sensitive Transcription Factors as Prime Targets for Chemoprevention with Anti-Inflammatory and Antioxidative Phytochemicals. J. Nutr. 135, 2993S-3001S.
DOI
|
| 24 |
Chen, Z. H., Na, H. K., Hurh, Y. J. and Surh, Y. J. (2005) 4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-kappaB and ERK/MAPK. Toxicol. Appl. Pharmacol. 208, 46-56.
DOI
ScienceOn
|
| 25 |
Saeed, M., Zahid, M., Gunselman, S. J., Rogan, E. and Cavalieri, E. (2005) Slow loss of deoxyribose from the N7deoxyguanosine adducts of estradiol-3,4-quinone and hexestrol-3',4'-quinone. Implications for mutagenic activity. Steroids 70, 29-35.
DOI
ScienceOn
|
| 26 |
Zhao, Z., Kosinska, W., Khmelnitsky, M., Cavalieri, E. L., Rogan, E. G., Chakravarti, D., Sacks, P. G. and Guttenplan, J. B. (2006) Mutagenic activity of 4-hydroxyestradiol, but not 2-hydroxyestradiol, in BB rat2 embryonic cells, and the mutational spectrum of 4-hydroxyestradiol. Chem. Res. Toxicol. 19, 475-479.
DOI
ScienceOn
|
| 27 |
Saeed, M., Rogan, E., Fernandez, S. V., Sheriff, F., Russo, J. and Cavalieri, E. (2007) Formation of depurinating N3Adenine and N7Guanine adducts by MCF-10F cells cultured in the presence of 4-hydroxyestradiol. Int. J. Cancer 120, 1821-1824.
DOI
ScienceOn
|
| 28 |
Chen, J. Q. and Yager, J. D. (2004) Estrogen's effects on mitochondrial gene expression: mechanisms and potential contributions to estrogen carcinogenesis. Ann. N. Y. Acad. Sci. 1028, 258-272.
DOI
ScienceOn
|
| 29 |
Zahid, M., Kohli, E., Saeed, M., Rogan, E. and Cavalieri, E. (2006) The greater reactivity of estradiol-3,4-quinone vs estradiol-2,3-quinone with DNA in the formation of depurinating adducts: implications for tumor-initiating activity. Chem. Res. Toxicol. 19, 164-172.
DOI
ScienceOn
|
| 30 |
Embrechts, J., Lemiere, F., Van Dongen, W., Esmans, E. L., Buytaert, P., Van Marck, E., Kockx, M. and Makar, A. (2003) Detection of estrogen DNA-adducts in human breast tumor tissue and healthy tissue by combined nano LC-nano ES tandem mass spectrometry. J. Am. Sco. Mass Spectr. 14, 482-491.
DOI
ScienceOn
|
| 31 |
Chen, J. Q., Delannoy, M., Cooke, C. and Yager, J. D. (2004) Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells. Am. J. Physiol. Endocrinol. Metab. 286, E1011-1022.
DOI
ScienceOn
|
| 32 |
Demonacos, C. V., Karayanni, N., Hatzoglou, E., Tsiriyiotis, C., Spandidos, D. A. and Sekeris, C. E. (1996) Mitochondrial genes as sites of primary action of steroid hormones. Steroids 61, 226-232.
DOI
ScienceOn
|
| 33 |
Zhu, B. T., Han, G. Z., Shim, J. Y., Wen, Y. and Jiang, X. R. (2006) Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: Insights into the structural determinants favoring a differential subtype binding. Endocrinology 147, 4132-4150.
DOI
ScienceOn
|
| 34 |
Vincent, T. L. and Gatenby, R. A. (2008) An evolutionary model for initiation, promotion, and progression in carcinogenesis. Int. J. Oncol. 32, 729-737.
|
| 35 |
Purohit, A., Reed, M. J., Morris, N. C., Williams, G. J. and Potter, B. V. (1996) Regulation and inhibition of steroid sulfatase activity in breast cancer. Ann. N. Y. Acad. Sci. 784, 40-49.
DOI
|
| 36 |
Lavigne, J. A., Goodman, J. E., Fonong, T., Odwin, S., He, P., Roberts, D. W. and Yager, J. D. (2001) The effects of catechol-O-methyltransferase inhibition on estrogen metabolite and oxidative DNA damage levels in estradiol-treated MCF-7 cells. Cancer Res. 61, 7488-7494.
|
| 37 |
Banerjee, S. K., Banerjee, S., Li, S. A. and Li, J. J. (1994) Induction of chromosome aberrations in Syrian hamster renal cortical cells by various estrogens. Mutat. Res. 311, 191-197.
DOI
ScienceOn
|
| 38 |
Valko, M., Izakovic, M., Mazur, M., Rhodes, C. J. and Telser, J. (2004) Role of oxygen radicals in DNA damage and cancer incidence. Mol. Cell. Biochem. 266, 37-56.
DOI
ScienceOn
|
| 39 |
Duncan, L., Purohit, A., Howarth, N. M., Potter, B. V. and Reed, M. J. (1993) Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer. Cancer Res. 53, 298-303.
|
| 40 |
Bjornstrom, L. and Sjoberg, M. (2005) Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol. Endocrinol. 19, 833-842.
DOI
ScienceOn
|
| 41 |
Marino, M., Galluzzo, P. and Ascenzi, P. (2006) Estrogen signaling multiple pathways to impact gene transcription. Curr. Genomics 7, 497-508.
DOI
|
| 42 |
Safe, S. and Kim, K. (2008) Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways. J. Mol. Endocrinol. 41, 263-275.
DOI
ScienceOn
|
| 43 |
Levin, E. R. (2002) Cellular functions of plasma membrane estrogen receptors. Steroids 67, 471-475.
DOI
ScienceOn
|
| 44 |
Li, Y., Yao, J., Chang, M., Nikolic, D., Yu, L., Yager, J. D., Mesecar, A. D., van Breemen, R. B. and Bolton, J. L. (2004) Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-Omethyltransferase. Chem. Res. Toxicol. 17, 512-520.
DOI
ScienceOn
|
| 45 |
Stoica, G. E., Franke, T. F., Moroni, M., Mueller, S., Morgan, E., Iann, M. C., Winder, A. D., Reiter, R., Wellstein, A., Martin, M. B. and Stoica, A. (2003) Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway. Oncogene 22, 7998-8011.
DOI
ScienceOn
|
| 46 |
Levin, E. R. (2003) Bidirectional signaling between the estrogen receptor and the epidermal growth factor receptor. Mol. Endocrinol. 17, 309-317.
DOI
ScienceOn
|
| 47 |
Liao, J. K. (2003) Cross-coupling between the oestrogen receptor and phosphoinositide 3-kinase. Biochem. Soc. Trans. 31, 66-70.
DOI
|
| 48 |
Loriaux, D. L., Ruder, H. J., Knab, D. R. and Lipsett, M. B. (1972) Estrone sulfate, estrone, estradiol and estriol plasma levels in human pregnancy. J. Clin. Endocrinol. Metab. 35, 887-891.
DOI
|
| 49 |
Ruder, H. J., Loriaux, L. and Lipsett, M. B. (1972) Estrone sulfate: production rate and metabolism in man. J. Clin. Invest. 51, 1020-1033.
DOI
|
| 50 |
Carlstrom, K., Bergqvist, A. and Ljungberg, O. (1988) Metabolism of estrone sulfate in endometriotic tissue and in uterine endometrium in proliferative and secretory cycle phase. Feril. Steril. 49, 229-233.
DOI
|
| 51 |
Santen, R. J., Leszczynski, D., Tilson-Mallet, N., Feil, P. D., Wright, C., Manni, A. and Santner, S. J. (1986) Enzymatic control of estrogen production in human breast cancer: relative significance of aromatase versus sulfatase pathways. Ann. N. Y. Acad. Sci. 464, 126-137.
DOI
|
| 52 |
Yue, T. L., Wang, X., Louden, C. S., Gupta, S., Pillarisetti, K., Gu, J. L., Hart, T. K., Lysko, P. G. and Feuerstein, G. Z. (1997) 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression. Mol. Pharmacol. 51, 951-962.
DOI
|
| 53 |
Zhu, B. T., Evaristus, E. N., Antoniak, S. K., Sarabia, S. F., Ricci, M. J. and Liehr, J. G. (1996) Metabolic deglucuronidation and demethylation of estrogen conjugates as a source of parent estrogens and catecholestrogen metabolites in Syrian hamster kidney, a target organ of estrogen- induced tumorigenesis. Toxicol. Appl. Pharmacol. 136, 186-193.
DOI
ScienceOn
|
| 54 |
Walaszek, Z. (1990) Potential use of D-glucaric acid derivatives in cancer prevention. Cancer Lett. 54, 1-8.
DOI
ScienceOn
|
| 55 |
Watanabe, K., Takanashi, K., Imaoka, S., Funae, Y., Kawano, S., Inoue, K., Kamataki, T., Takagi, H. and Yoshizawa, I. (1991) Comparison of cytochrome P-450 species which catalyze the hydroxylations of the aromatic ring of estradiol and estradiol 17-sulfate. J. Steroid Biochem. Mol. Biol. 38, 737-743.
DOI
ScienceOn
|
| 56 |
Schumacher, G. and Neuhaus, P. (2001) The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors. J. Cancer Res. Clin. Oncol. 127, 405-410.
DOI
|
| 57 |
Schumacher, G., Kataoka, M., Roth, J. A. and Mukhopadhyay, T. (1999) Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines. Clin. Cancer Res. 5, 493-499.
|
| 58 |
Pribluda, V. S., Gubish, E. R., Jr., Lavallee, T. M., Treston, A., Swartz, G. M. and Green, S. J. (2000) 2-Methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate. Cancer Metastasis Rev. 19, 173-179.
DOI
ScienceOn
|
| 59 |
Yao, J., Chang, M., Li, Y., Pisha, E., Liu, X., Yao, D., Elguindi, E. C., Blond, S. Y. and Bolton, J. L. (2002) Inhibition of cellular enzymes by equine catechol estrogens in human breast cancer cells: specificity for glutathione S-transferase P1-1. Chem. Res. Toxicol. 15, 935-942.
DOI
ScienceOn
|
| 60 |
Yao, J., Li, Y., Chang, M., Wu, H., Yang, X., Goodman, J. E., Liu, X., Liu, H., Mesecar, A. D., Van Breemen, R. B., Yager, J. D. and Bolton, J. L. (2003) Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol- O-methyltransferase. Chem. Res. Toxicol. 16, 668-675.
DOI
ScienceOn
|
| 61 |
Chang, M., Shin, Y. G., van Breemen, R. B., Blond, S. Y. and Bolton, J. L. (2001) Structural and functional consequences of inactivation of human glutathione S-transferase P1-1 mediated by the catechol metabolite of equine estrogens, 4-hydroxyequilenin. Biochemistry 40, 4811-4820.
DOI
ScienceOn
|
| 62 |
Zhang, F. and Bolton, J. L. (1999) Synthesis of the equine estrogen metabolites 2-hydroxyequilin and 2-hydroxyequilenin. Chem. Res. Toxicol. 12, 200-203.
DOI
ScienceOn
|
| 63 |
Roy, D., Bernhardt, A., Strobel, H. W. and Liehr, J. G. (1992) Catalysis of the oxidation of steroid and stilbene estrogens to estrogen quinone metabolites by the beta-naphthoflavone-inducible cytochrome P450 IA family. Arch. Biochem. Biophys. 296, 450-456.
DOI
ScienceOn
|
| 64 |
Markides, C. S., Roy, D. and Liehr, J. G. (1998) Concentration dependence of prooxidant and antioxidant properties of catecholestrogens. Arch. Biochem. Biophys. 360, 105-112.
DOI
ScienceOn
|
| 65 |
Roy, D. and Liehr, J. G. (1999) Estrogen, DNA damage and mutations. Mutat. Res. 424, 107-115.
DOI
ScienceOn
|
| 66 |
Rajapakse, N., Butterworth, M. and Kortenkamp, A. (2005) Detection of DNA strand breaks and oxidized DNA bases at the single-cell level resulting from exposure to estradiol and hydroxylated metabolites. Environ. Mol. Mutagen. 45, 397-404.
DOI
ScienceOn
|
| 67 |
Merriam, G. R., MacLusky, N. J., Picard, M. K. and Naftolin, F. (1980) Comparative properties of the catechol estrogens, I: methylation by catechol-O-methyltransferase and binding to cytosol estrogen receptors. Steroids 36, 1-11.
DOI
ScienceOn
|
| 68 |
Hobkirk, R. (1985) Steroid sulfotransferases and steroid sulfate sulfatases: characteristics and biological roles. Can. J. Biochem. Cell Biol. 63, 1127-1144.
DOI
|
| 69 |
Roy, A. K. (1992) Regulation of steroid hormone action in target cells by specific hormone-inactivating enzymes. Proc. Soc. Exp. Biol. Med. 199, 265-272.
DOI
|
| 70 |
Ball, P. and Knuppen, R. (1990) Formation, metabolism, and physiologic importance of catecholestrogens. Am. J. Obstet. Gynecol. 163, 2163-2170.
DOI
ScienceOn
|
| 71 |
Liehr, J. G., Fang, W. F., Sirbasku, D. A. and Ari- Ulubelen, A. (1986) Carcinogenicity of catechol estrogens in Syrian hamsters. J. Steroid Biochem. Mol. Biol. 24, 353-356.
DOI
ScienceOn
|
| 72 |
Li, J. J. and Li, S. A. (1987) Estrogen carcinogenesis in Syrian hamster tissues: role of metabolism. Fed. Proc. 46, 1858-1863.
|
| 73 |
Newbold, R. R. and Liehr, J. G. (2000) Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens. Cancer Res. 60, 235-237.
|
| 74 |
Li, K. M., Todorovic, R., Devanesan, P., Higginbotham, S., Kofeler, H., Ramanathan, R., Gross, M. L., Rogan, E. G. and Cavalieri, E. L. (2004) Metabolism and DNA binding studies of 4-hydroxyestradiol and estradiol-3,4-quinone in vitro and in female ACI rat mammary gland in vivo. Carcinogenesis 25, 289-297.
|
| 75 |
El-Bayoumy, K., Ji, B. Y., Upadhyaya, P., Chae, Y. H., Kurtzke, C., Rivenson, A., Reddy, B. S., Amin, S. and Hecht, S. S. (1996) Lack of tumorigenicity of cholesterol epoxides and estrone-3,4-quinone in the rat mammary gland. Cancer Res. 56, 1970-1973.
|
| 76 |
Yamazaki, H., Shaw, P. M., Guengerich, F. P. and Shimada, T. (1998) Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes. Chem. Res. Toxicol. 11, 659-665.
DOI
ScienceOn
|
| 77 |
Franks, S., MacLusky, N. J. and Naftolin, F. (1982) Comparative pharmacology of oestrogens and catechol oestrogens: actions on the immature rat uterus in vivo and in vitro. J. Endocrinol. 94, 91-98.
DOI
ScienceOn
|
| 78 |
Van Aswegen, C. H., Purdy, R. H. and Wittliff, J. L. (1989) Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J. Steroid Biochem. 32, 485-492.
DOI
ScienceOn
|
| 79 |
Spink, D. C., Zhang, F., Hussain, M. M., Katz, B. H., Liu, X., Hilker, D. R. and Bolton, J. L. (2001) Metabolism of equilenin in MCF-7 and MDA-MB-231 human breast cancer cells. Chem. Res. Toxicol. 14, 572-581.
DOI
ScienceOn
|
| 80 |
Zhu, B. T. and Conney, A. H. (1998) Functional role of estrogen metabolism in target cells: review and perspectives. Carcinogenesis 19, 1-27.
DOI
ScienceOn
|
| 81 |
Chang, M., Peng, K. W., Kastrati, I., Overk, C. R., Qin, Z. H., Yao, P., Bolton, J. L. and Thatcher, G. R. (2007) Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells. Endocrinology 148, 4793-4802.
DOI
ScienceOn
|
| 82 |
Tsutsui, T., Tamura, Y., Hagiwara, M., Miyachi, T., Hikiba, H., Kubo, C. and Barrett, J. C. (2000) Induction of mammalian cell transformation and genotoxicity by 2-methoxyestradiol, an endogenous metabolite of estrogen. Carcinogenesis 21, 735-740.
DOI
ScienceOn
|
| 83 |
Sutherland, T. E., Schuliga, M., Harris, T., Eckhardt, B. L., Anderson, R. L., Quan, L. and Stewart, A. G. (2005) 2-Methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer. Clin. Cancer Res. 11, 1722-1732.
DOI
ScienceOn
|
| 84 |
Suchar, L. A., Chang, R. L., Rosen, R. T., Lech, J. and Conney, A. H. (1995) High-performance liquid chromatography separation of hydroxylated estradiol metabolites: formation of estradiol metabolites by liver microsomes from male and female rats. J. Pharmacol. Exp. Ther. 272, 197-206.
|
| 85 |
Parl, F. F., Egan, K. M., Li, C. and Crooke, P. S. (2009) Estrogen exposure, metabolism, and enzyme variants in a model for breast cancer risk prediction. Cancer Inform. 7, 109-121.
|
| 86 |
Crooke, P. S., Justenhoven, C., Brauch, H. B., Dawling, S., Roodi, N., Higginbotham, K. S., Plummer, W. D., Jr., Schuyler, P. A., Sanders, M. E., Page, D. L., Smith, J. R., Dupont, W. D. and Parl, F. F. (2011) Estrogen metabolism and exposure in a genotypic-phenotypic model for breast cancer risk prediction. Cancer Epidemiol. Biomarkers Prev. 20, 1502-1515.
DOI
ScienceOn
|
| 87 |
Williamson, D. G. (1979) The biochemistry of the 17-hydroxysteroid dehydrogenases; in Steroid Biochemistry. (Hobkirk, R., ed.), pp. 83-110, CRC Press, Boca Raton, FL.
|
| 88 |
Russo, J. and Russo, I. H. (2006) The role of estrogen in the initiation of breast cancer. J. Steroid Biochem. Mol. Biol. 102, 89-96.
DOI
ScienceOn
|
| 89 |
Sarabia, S. F., Zhu, B. T., Kurosawa, T., Tohma, M. and Liehr, J. G. (1997) Mechanism of cytochrome P450-catalyzed aromatic hydroxylation of estrogens. Chem. Res. Toxicol. 10, 767-771.
DOI
ScienceOn
|
| 90 |
Raftogianis, R., Creveling, C., Weinshilboum, R. and Weisz, J. (2000) Estrogen metabolism by conjugation. J. Natl. Cancer Inst. Monogr. 27, 113-124.
|
| 91 |
Hachey, D. L., Dawling, S., Roodi, N. and Parl, F. F. (2003) Sequential action of phase I and II enzymes cytochrome p450 1B1 and glutathione S-transferase P1 in mammary estrogen metabolism. Cancer Res. 63, 8492-8499.
|
| 92 |
Peng, K. W., Chang, M., Wang, Y. T., Wang, Z., Qin, Z., Bolton, J. L. and Thatcher, G. R. (2010) Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation. Chem. Res. Toxicol. 23, 1374-1383.
DOI
ScienceOn
|
| 93 |
Yue, W., Santen, R. J., Wang, J. P., Li, Y., Verderame, M. F., Bocchinfuso, W. P., Korach, K. S., Devanesan, P., Todorovic, R., Rogan, E. G. and Cavalieri, E. L. (2003) Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis. J. Steroid Biochem. Mol. Biol. 86, 477-486.
DOI
ScienceOn
|
| 94 |
Russo, J., Fernandez, S. V., Russo, P. A., Fernbaugh, R., Sheriff, F. S., Lareef, H. M., Garber, J. and Russo, I. H. (2006) 17-Beta-estradiol induces transformation and tumorigenesis in human breast epithelial cells. FASEB J. 20, 1622-1634.
DOI
ScienceOn
|
| 95 |
Russo, J., Hasan Lareef, M., Balogh, G., Guo, S. and Russo, I. H. (2003) Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells. J. Steroid Biochem. Mol. Biol. 87, 1-25.
DOI
ScienceOn
|
| 96 |
Schutze, N., Vollmer, G. and Knuppen, R. (1994) Catecholestrogens are agonists of estrogen receptor dependent gene expression in MCF-7 cells. J. Steroid Biochem. Mol. Biol. 48, 453-461.
DOI
ScienceOn
|
| 97 |
Kaaks, R., Berrino, F., Key, T., Rinaldi, S., Dossus, L., Biessy, C., Secreto, G., Amiano, P., Bingham, S., Boeing, H., Bueno de Mesquita, H. B., Chang-Claude, J., Clavel-Chapelon, F., Fournier, A., van Gils, C. H., Gonzalez, C. A., Gurrea, A. B., Critselis, E., Khaw, K. T., Krogh, V., Lahmann, P. H., Nagel, G., Olsen, A., Onland-Moret, N. C., Overvad, K., Palli, D., Panico, S., Peeters, P., Quiros, J. R., Roddam, A., Thiebaut, A., Tjonneland, A., Chirlaque, M. D., Trichopoulou, A., Trichopoulos, D., Tumino, R., Vineis, P., Norat, T., Ferrari, P., Slimani, N. and Riboli, E. (2005) Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). J. Natl. Cancer Inst. 97, 755-765.
DOI
ScienceOn
|
| 98 |
Castagnetta, L., Granata, O. M., Cocciadiferro, L., Saetta, A., Polito, L., Bronte, G., Rizzo, S., Campisi, I., Agostara, B. and Carruba, G. (2004) Sex steroids, carcinogenesis, and cancer progression. Ann. N.Y. Acad. Sci. 1028, 233-246.
DOI
ScienceOn
|
| 99 |
Zucchetto, A., Serraino, D., Polesel, J., Negri, E., De Paoli, A., Dal Maso, L., Montella, M., La Vecchia, C., Franceschi, S. and Talamini, R. (2009) Hormone-related factors and gynecological conditions in relation to endometrial cancer risk. Eur. J. Cancer Prev. 18, 316-321.
DOI
ScienceOn
|
| 100 |
Russo, J., Hu, Y. F., Yang, X. and Russo, I. H. (2000) Developmental, cellular, and molecular basis of human breast cancer. J. Natl. Cancer Inst. Monogr. 27, 17-37.
|
| 101 |
Bocchinfuso, W. P. and Korach, K. S. (1997) Mammary gland development and tumorigenesis in estrogen receptor knockout mice. J. Mal. Gland Biol. Neoplasia 2, 323-334.
DOI
ScienceOn
|
| 102 |
The National Toxicology Program (NTP). (2002) Federal Report on Carcinogens. 177283-177285.
|
| 103 |
WHO (1999) Hormonal Contraception and Post-Menopausal Hormonal Therapy; in IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, pp. 399-530, IARCPress, Lyon, France.
|
| 104 |
Yager, J. D. and Davidson, N. E. (2006) Estrogen carcinogenesis in breast cancer. N. Engl. J. Med. 354, 270-282.
DOI
ScienceOn
|
| 105 |
Colditz, G. A. (1998) Relationship between estrogen levels, use of hormone replacement therapy, and breast cancer. J. Natl. Cancer I. 90, 814-823.
DOI
ScienceOn
|
| 106 |
Beatson, G. T. (1896) On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment with illustrative cases. Lancet 2, 104-107.
|
| 107 |
Simpson, E. R. (2003) Sources of estrogen and their importance. J. Steroid Biochem. Mol. Biol. 86, 225-230.
DOI
ScienceOn
|
| 108 |
Boukari, K., Ciampi, M. L., Guiochon-Mantel, A., Young, J., Lombes, M. and Meduri, G. (2007) Human fetal testis:source of estrogen and target of estrogen action. Hum. Reprod. 22, 1885-1892.
DOI
ScienceOn
|
| 109 |
Feigelson, H. S. and Henderson, B. E. (1996) Estrogens and breast cancer. Carcinogenesis 17, 2279-2284.
DOI
ScienceOn
|
| 110 |
Xu, W. H., Xiang, Y. B., Ruan, Z. X., Zheng, W., Cheng, J. R., Dai, Q., Gao, Y. T. and Shu, X. O. (2004) Menstrual and reproductive factors and endometrial cancer risk: results from a population-based case-control study in urban Shanghai. Int. J. Cancer 108, 613-619.
DOI
ScienceOn
|
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