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http://dx.doi.org/10.5483/BMBRep.2011.44.3.187

Characterization of the TAK1 gene in Apis cerana cerana(AccTAK1) and its involvement in the regulation of tissue-specific development  

Meng, Fei (State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University)
Kang, Mingjiang (College of Animal Science and Technology, Shandong Agricultural University)
Liu, Li (College of Animal Science and Technology, Shandong Agricultural University)
Luo, Lu (State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University)
Xu, Baohua (College of Animal Science and Technology, Shandong Agricultural University)
Guo, Xingqi (State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University)
Publication Information
BMB Reports / v.44, no.3, 2011 , pp. 187-192 More about this Journal
Abstract
TGF-$\beta$ activated kinase-1 (TAK1) plays a pivotal role in developmental processes in many species. Previous research has mainly focused on the function of TAK1 in model organisms, and little is known about the function of TAK1 in hymenoptera insects. Here, we isolated and characterized the TAK1 gene from Apis cerana cerana. Promoter analysis of AccTAK1 revealed the presence of transcription factor binding sites related to early development. Real-time quantitative PCR and immunohistochemistry experiments revealed that AccTAK1 was expressed at high levels in fourth instar larvae, primarily in the abdomen, in the intestinal wall cells of the midgut and in the secretory cells of the salivary glands. In addition, AccTAK1 expression in fourth instar larvae could be dramatically induced by treatment with pesticides and organic solvents. These observations suggest that AccTAK1 may be involved in the regulation of early development in the larval salivary gland and midgut.
Keywords
AccTAK1; Apis cerana cerana; Development characterization; Expression pattern; Immunohistochemistry;
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