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http://dx.doi.org/10.5483/BMBRep.2011.44.2.135

Effects of chronic alcohol consumption on expression levels of APP and Aβ-producing enzymes  

Kim, Sae-Rom (School of Pharmacy, Sungkyunkwan University)
Jeong, Hye-Young (School of Pharmacy, Sungkyunkwan University)
Yang, Sung-Hee (School of Pharmacy, Sungkyunkwan University)
Choi, Sung-Pil (Department of Food Science and Biotechnology, Sungkyunkwan University)
Seo, Min-Young (Department of Food Science and Biotechnology, Sungkyunkwan University)
Yun, Young-Kwang (School of Pharmacy, Sungkyunkwan University)
Choi, Yu-Ri (School of Pharmacy, Sungkyunkwan University)
Baik, Sang-Ha (School of Pharmacy, Sungkyunkwan University)
Park, Jong-Sung (School of Pharmacy, Sungkyunkwan University)
Gwon, A-Ryeong (School of Pharmacy, Sungkyunkwan University)
Yang, Dong-Kwon (Department of Life Science, Gwangju Institute of Science and Technology)
Lee, Chan-Ho (School of Pharmacy, Sungkyunkwan University)
Lee, Sun-Mee (School of Pharmacy, Sungkyunkwan University)
Park, Kye-Won (Department of Food Science and Biotechnology, Sungkyunkwan University)
Jo, Dong-Gyu (School of Pharmacy, Sungkyunkwan University)
Publication Information
BMB Reports / v.44, no.2, 2011 , pp. 135-139 More about this Journal
Abstract
Chronic alcohol consumption contributes to numerous diseases, including cancers, cardiovascular diseases, and liver cirrhosis. Epidemiological studies have shown that excessive alcohol consumption is a risk factor for dementia. Along this line, Alzheimer's disease (AD) is the most common form of dementia and is caused by the accumulation of amyloid-$\beta$ ($A{\beta}$ plaques in neurons. In this study, we hypothesized that chronic ethanol consumption is associated with pathological processing of APP in AD. To investigate the relationship between chronic alcohol consumption and $A{\beta}$ production, brain samples from rats fed an alcohol liquid diet for 5 weeks were analyzed. We show that the expression levels of APP, BACE1, and immature nicastrin were increased in the cerebellum, hippocampus, and striatum of the alcohol-fed group compared to the control group. Total nicastrin and PS1 levels were induced in the hippocampus of alcohol-fed rats. These data suggest that the altered expression of APP and $A{\beta}$-producing enzymes possibly contributes to the chronic alcohol consumption-mediated pathogenesis of AD.
Keywords
Alzheimer's disease; $\beta$-secretase; Chronic alchol consumption; Notch; $\gamma$-secreatse;
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