[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5483/BMBRep.2010.43.8.554

Smad4 mediates malignant behaviors of human ovarian carcinoma cell through the effect on expressions of E-cadherin, plasminogen activator inhibitor-1 and VEGF

Chen, Chen (Key Laboratory for Proteomics of Liaoning Province, Dalian Medical University)
Sun, Ming-Zhong (Key Laboratory for Proteomics of Liaoning Province, Dalian Medical University)
Liu, Shuqing (Key Laboratory for Proteomics of Liaoning Province, Dalian Medical University)
Yeh, Dongmei (Key Laboratory for Proteomics of Liaoning Province, Dalian Medical University)
Yu, Lijun (Key Laboratory for Proteomics of Liaoning Province, Dalian Medical University)
Song, Yang (Key Laboratory for Proteomics of Liaoning Province, Dalian Medical University)
Gong, Linlin (Key Laboratory for Proteomics of Liaoning Province, Dalian Medical University)
Hao, Lihong (Key Laboratory for Proteomics of Liaoning Province, Dalian Medical University)
Hu, Jun (Key Laboratory for Proteomics of Liaoning Province, Dalian Medical University)
Shao, Shujuan (Key Laboratory for Proteomics of Liaoning Province, Dalian Medical University)

Publication Information

BMB Reports / v.43, no.8, 2010 , pp. 554-560 More about this Journal

Abstract

Smad4 is involved in cancer progression and metastasis. Using a pair of human syngeneic epithelial ovarian cancer cells with low (HO-8910) and high (HO-8910PM) metastatic abilities, we aimed to reveal the role of Smad4 in ovarian cancer metastasis in vitro. Smad4 was down-regulated in HO-8910PM cell line relative to HO-8910 by implicating Smad4 was probably a potential tumor suppressor gene for ovarian cancer. Re-expression of Smad4 decreased the migration ability and inhibited the invasion capacity of HO-8910PM, while promoted the cell adhesion capacity for HO-8910PM. The stable expression of Smad4 increased the expression of E-cadherin, reduced the expression of plasminogen activator inhibitor-1 (PAI-1) and slightly down-regulated the expression of VEGF. Smad4 suppresses human ovarian cancer cell metastasis potential through its effect on the expressions of PAI-1, E-cadherin and VEGF. Results from current work implicate Smad4 might suppress the invasion and metastasis of human ovarian tumor cells through a TGF- $\beta$ /Smad-mediated pathway.

Keywords

Invasion; Ovarian cancer; Progression; Smad4; Tumor metastasis;

Citations & Related Records

Times Cited By Web Of Science : 1 (Related Records In Web of Science)
Times Cited By SCOPUS : 1

Reference
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