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http://dx.doi.org/10.5483/BMBRep.2010.43.6.445

Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics  

Park, Byung-Lae (Department of Genetic Epidemiology, SNP Genetics, Inc.)
Park, Se-Min (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital)
Park, Jong-Sook (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital)
Uh, Soo-Taek (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital)
Choi, Jae-Sung (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital)
Kim, Yong-Hoon (Division of Internal Medicine, Chungbuk National University, College of Medicine)
Kim, Mi-Kyeong (Department of Allergy, Chonnam National University Medical School and Research Institute of Medical Sciences)
Choi, In-Seon S. (Division of Pulmonology and Allergy, Department of Internal Medicine, Chung-Ang University Yongsan Hospital)
Choi, Byoung-Whui (Department of Internal Medicine and Institute of Allergy and Clinical Immunology, Seoul National University College of Medicine)
Cho, Sang-Heon (Division of Allergy and Immunology, Institute of Allergy, Department of Internal Medicine, Yonsei University College of Medicine)
Hong, Chein-Soo (Pulmonary, Allergy & Critical Care Medicine, Hallym University College of Medicine)
Lee, Yong-Won (Pulmonary, Allergy & Critical Care Medicine, Hallym University College of Medicine)
Lee, Jae-Young (Department of Life Science, Sogang University)
Park, Choon-Sik (Genome Research Center for Allergy and Respiratory Medicine, Soonchunhyang University Hospital)
Shin, Hyoung-Doo (Department of Genetic Epidemiology, SNP Genetics, Inc.)
Publication Information
BMB Reports / v.43, no.6, 2010 , pp. 445-449 More about this Journal
Abstract
Aspirin-intolerant asthma (AIA) is characterized by severe asthmatic attack after ingestion of aspirin and/or non-steroidal anti-inflammatory drugs. In this study, we investigated the relationship between Prostaglandin E2 receptor (PTGER) gene family polymorphisms and AIA in 243 AIA patients and 919 aspirin-tolerant asthma (ATA) controls of Korean ethnicity in two separate study cohorts. After genotyping 120 SNPs of the PTGER gene family for the $1^{st}$ cohort study, four SNPs in PTGER1, ten in PTGER3, six in PTGER3, and a haplotype of PTGER2 showed association signals with decreased or increased risk of AIA. Among the positively associated SNPs, one in PTGER1 and four in PTGER3 were analyzed in the $2^{nd}$ cohort study. The results show that rs7543182 and rs959 in PTGER3 retained their effect, although no statistical significance was retained in the $2^{nd}$ cohort study. Our findings provide further evidence that polymorphisms in PTGER3 might play a significant role in aspirin hypersensitivity among Korean asthmatics.
Keywords
Aspirin intolerant asthma; Asthma; Prostaglandin E receptor(s); Single nucleotide polymorphism;
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