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http://dx.doi.org/10.5483/BMBRep.2010.43.4.225

The role of neuroinflammation on the pathogenesis of Parkinson's disease

Chung, Young-Cheul (Department of Biochemistry & Molecular Biology, Neurodegeneration Control Research Center, School of Medicine Kyung Hee University)
Ko, Hyuk-Wan (Department of Biochemistry & Molecular Biology, Neurodegeneration Control Research Center, School of Medicine Kyung Hee University)
Bok, Eu-Gene (Department of Biochemistry & Molecular Biology, Neurodegeneration Control Research Center, School of Medicine Kyung Hee University)
Park, Eun-Soo (Department of Biochemistry & Molecular Biology, Neurodegeneration Control Research Center, School of Medicine Kyung Hee University)
Huh, Sue-Hee (Department of Biochemistry & Molecular Biology, Neurodegeneration Control Research Center, School of Medicine Kyung Hee University)
Nam, Jin-Han (Department of Biochemistry & Molecular Biology, Neurodegeneration Control Research Center, School of Medicine Kyung Hee University)
Jin, Byung-Kwan (Department of Biochemistry & Molecular Biology, Neurodegeneration Control Research Center, School of Medicine Kyung Hee University)

Publication Information

BMB Reports / v.43, no.4, 2010 , pp. 225-232 More about this Journal

Abstract

Parkinson's Disease (PD) is a common neurodegenerative disease characterized by the progressive degeneration of nigrostriatal dopaminergic (DA) neurons. Although the causative factors of PD remain elusive, many studies on PD animal models or humans suggest that glial activation along with neuroinflammatory processes contribute to the initiation or progression of PD. Additionally, several groups have proposed that dysfunction of the blood-brain barrier (BBB) combined with infiltration of peripheral immune cells play important roles in the degeneration of DA neurons. However, these neuroinflammatory events have only been investigated separately, and the issue of whether these phenomena are neuroprotective or neurotoxic remains controversial. We here review the current knowledge regarding the functions of these neuroinflammatory processes in the brain. Finally, we describe therapeutic strategies for the regulation of neuroinflammation with the goal of improving the symptoms of PD.

Keywords

Astrocyte; BBB leakage; Infiltration of peripheral immune cells; Microglia; Parkinson's disease;

Citations & Related Records

Times Cited By Web Of Science : 20 (Related Records In Web of Science)
Times Cited By SCOPUS : 22

Reference
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1559-1182	(2018) Molecular Neurobiology Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress / (1559-1182)
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1	(2018) Journal of Neuroinflammation Interaction of systemic oxidative stress and mesial temporal network degeneration in Parkinson’s disease with and without cognitive impairment / 15 (1)
7	(2018) Experimental & Molecular Medicine Modulation of M1/M2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned substantia nigra in vivo / 50 (7)
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