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http://dx.doi.org/10.5483/BMBRep.2010.43.3.219

Reaction of ferritin with hydrogen peroxide induces lipid peroxidation  

Yoon, Hung-Hwan (Department of Genetic Engineering, Cheongju University)
Lee, Myeong-Seon (Department of Genetic Engineering, Cheongju University)
Kang, Jung-Hoon (Department of Genetic Engineering, Cheongju University)
Publication Information
BMB Reports / v.43, no.3, 2010 , pp. 219-224 More about this Journal
Abstract
Lipid peroxidation is known to be an important factor in the pathologies of many diseases associated with oxidative stress. We assessed the lipid peroxidation induced by the reaction of ferritin with $H_2O_2$. When linoleic acid micelles or phosphatidyl choline liposomes were incubated with ferritin and $H_2O_2$, lipid peroxidation increased in the presence of ferritin and $H_2O_2$ in a concentration-dependent manner. The hydroxyl radical scavengers, azide and thiourea, prevented lipid peroxidation induced by the ferritin/$H_2O_2$ system. The iron specific chelator desferoxamine also prevented ferritin/$H_2O_2$ systemmediated lipid peroxidation. These results demonstrate the possible role of iron in ferritin/$H_2O_2$ system-mediated lipid peroxidation. Carnosine is involved in many cellular defense processes, including free radical detoxification. In this study, carnosine, homocarnosine, and anserine were shown to significantly prevent ferritin/$H_2O_2$ system-mediated lipid peroxidation and also inhibited the free radical-generation activity of ferritin. These results indicated that carnosine and related compounds may prevent ferritin/$H_2O_2$ system-mediated lipid peroxidation via free radical scavenging.
Keywords
Carnosine; Ferritin; Hydroxyl radical; Lipid peroxidation;
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Times Cited By Web Of Science : 2  (Related Records In Web of Science)
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