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http://dx.doi.org/10.5483/BMBRep.2010.43.3.158

Characterization of calumenin in mouse heart  

Sahoo, Sanjaya Kumar (Department of Life Science and Systems Biology Research Center, Gwangju Institute of Science and Technology (GIST))
Kim, Do-Han (Department of Life Science and Systems Biology Research Center, Gwangju Institute of Science and Technology (GIST))
Publication Information
BMB Reports / v.43, no.3, 2010 , pp. 158-163 More about this Journal
Abstract
Calumenin is a multiple EF-hand $Ca^{2+}$-binding protein located in the endo/sarcoplasmic reticulum of mammalian hearts. Calumenin belongs to the CREC family of $Ca^{2+}$-binding proteins having multiple EF-hands. $Ca^{2+}$ homeostasis in the sarcoplasmic reticulum (SR) of mammalian hearts is maintained by RyR2, SERCA2 and other associated SR resident proteins. Evidence suggests that calumenin interacts with RyR2 and SERCA2, and therefore changes in the expression of calumenin could alter $Ca^{2+}$ cycling in mouse heart. In this review, current knowledge of the biochemical and functional roles of calumenin in mouse heart is described.
Keywords
Excitation-contraction coupling; Mammalian heart; Ryanodine receptor; SERCA; Striated muscle; Systems biology;
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Times Cited By Web Of Science : 3  (Related Records In Web of Science)
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