Streptomyces BAC Cloning of a Large-Sized Biosynthetic Gene Cluster of NPP B1, a Potential SARS-CoV-2 RdRp Inhibitor |
Park, Ji-Hee
(Department of Biological Sciences and Bioengineering, Inha University)
Park, Heung-Soon (Department of Biological Sciences and Bioengineering, Inha University) Nah, Hee-Ju (Department of Biological Sciences and Bioengineering, Inha University) Kang, Seung-Hoon (Department of Biological Sciences and Bioengineering, Inha University) Choi, Si-Sun (Department of Biological Sciences and Bioengineering, Inha University) Kim, Eung-Soo (Department of Biological Sciences and Bioengineering, Inha University) |
1 | Nah HJ, Pyeon HR, Kang SH, Choi SS, Kim ES. 2017. Cloning and heterologous expression of a large-sized natural product biosynthetic gene cluster in Streptomyes Species. Front. Microbiol 8: 394. |
2 | Choi SS, Katsuyama Y, Bai L, Deng Z, Ohnishi Y, Kim ES. 2018. Genome engineering for microbial natural product discovery. Curr. Opin. Microbiol. 45: 55-60. |
3 | Greunke C, Duell ER, D'Agostino PM, Glockle A, Lamm K, Gulder T. 2018. Direct pathway cloning (DiPaC) to unlock natural product biosynthetic potential. Metab. Eng. 47: 334-345. DOI |
4 | Larson CB, Crusemann M, Moore BS. 2017. PCR-independent method of transformation-associated recombination reveals the cosmomycin biosynthetic gene cluster in an ocean Streptomycete. J. Nat. Prod. 80: 1200-1204. DOI |
5 | Kang HS, Kim ES. 2021. Recent advances in heterologous expression of natural product biosynthetic gene clusters in Streptomyces hosts. Curr. Opin. Biotechnol. 69: 118-127. DOI |
6 | Hun K, Kim SJ, Park SN, Oh JW. 2004. Antiviral effect of amphotericin B on Japanese Encephalitis virus replication. J. Microbiol. Biotechnol. 14: 121-127. |
7 | Al-Khikani FHO. 2020. Amphotericin B as antiviral drug: possible efficacy against COVID-19. Ann. Thorac. Med. 15: 118-124. DOI |
8 | Khare P, Sahu U, Pandey SC, Samant M. 2020. Current approaches for target-specific drug discovery using natural compounds against SARS-CoV-2 infection. Virus Res. 290: 198169. |
9 | Zhang JJ, Yamanaka K, Tang X, Moore BS. 2019. Direct cloning and heterologous expression of natural product biosynthetic gene clusters by transformation-associated recombination. Methods Enzymol. 621: 87-110. DOI |
10 | Xu M, Wang Y, Zhao Z, Gao G, Huang SX, Kang Q, et al. 2016. Functional genome mining for metabolites encoded by large gene clusters through heterologous expression of a whole-genome bacterial artificial chromosome library in Streptomyces spp. Appl. Environ. Microbiol. 82: 5795-5805. DOI |
11 | Won HJ, Kim HJ, Jang JY, Kang SH, Choi SS, Kim ES. 2017. Improved recovery and biological activities of an engineered polyene NPP analogue in Pseudonocardia autotrophica. J. Ind. Microbiol. Biotechnol. 44: 1293-1299. DOI |
12 | Nah HJ. Woo MW, Choi SS, Kim ES. 2015. Precise cloning and tandem integration of large polyketide biosynthetic gene cluster using Streptomyces artificial chromosome system. Microb. Cell Fact. 14: 140. |
13 | Jeon HG, Seo J, Lee MJ, Han K, Kim ES. 2011. Analysis and functional expression of NPP pathway-specific regulatory genes in Pseudonocardia autotrophica. J. Ind. Microbiol. Biotechnol. 38: 573-579. DOI |
14 | Fjaervik E, Zotchev SB. 2005. Biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei. Appl. Microbiol. Biotechnol. 67: 436-443. DOI |
15 | Lu J, Long Q, Zhao Z, Chen L, He W, Hong J, et al. 2020. Engineering the erythromycin-producing strain Saccharopolyspora erythraea HOE107 for the heterologous production of polyketide antibiotics. Front. Microbiol. 11: 593217. |
16 | Genilloud O. 2017. Actinomycetes: still a source of novel antibiotics. Nat. Prod. Rep. 34: 1203-1232. DOI |
17 | Xu M, Wright GD. 2019. Heterologous expression-facilitated natural products' discovery in actinomycetes. J. Ind. Microbiol. Biotechnol. 46: 415-431. DOI |
18 | Dhakal D, Sohng JK, Pandey RP. 2019. Engineering actinomycetes for biosynthesis of macrolactone polyketides. Microb. Cell Fact. 18: 137. |
19 | Kim HJ, Kim MK, Lee MJ, Won HJ, Choi SS, Kim ES. 2015. Post-PKS tailoring steps of a disaccharide-containing polyene NPP in Pseudonocardia autotrophica. PLoS One 10: e0123270. |
20 | Caffrey P, De Poire E, Sheehan J, Sweeney P. 2016. Polyene macrolide biosynthesis in streptomycetes and related bacteria: recent advances from genome sequencing and experimental studies. Appl. Microbiol. Biotech. 100: 3893-3908. DOI |
21 | Lee MJ, Kong D, Han K, Sherman DH, Bai L, Deng Z, et al. 2012. Structural analysis and biosynthetic engineering of a solubilityimproved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica. Appl. Microbiol. Biotechnol. 95: 157-168. DOI |
22 | Saez-Alvarez Y, Arias A, Del Aguila C, Agudo R. 2019. Development of a fluorescence-based method for the rapid determination of Zika virus polymerase activity and the screening of antiviral drugs. Sci. Rep. 9: 5397. |
23 | Zhang B, Wang KB, Wang W, Bi SF, Mei YN, Deng XZ, et al. 2018. Discovery, biosynthesis, and heterologous production of Streptoseomycin, an anti-microaerophilic bacteria macrodilactone. Org. Lett. 20: 2967-2971. DOI |
24 | Kim HJ, Han CY, Park JS, Oh SH, Kang SH, Choi SS, et al. 2018. Nystatin-like Pseudonocardia polyene B1, a novel disaccharidecontaining antifungal heptaene antibiotic. Sci. Rep. 8: 13584. |
25 | Han CY, Jang JY, Kim HJ, Choi SS, Kim ES. 2019. Pseudonocardia strain improvement for stimulation of the di-sugar heptaene Nystatin-like Pseudonocardia polyene B1 biosynthesis. J. Ind. Microbiol. Biotechnol. 46: 649-655. DOI |
26 | Martinet L, Naome A, Deflandre B, Maciejewska M, Tellatin D, Tenconi E, et al. 2019. A single biosynthetic gene cluster is responsible for the production of bagremycin antibiotics and Ferroverdin Iron Chelators. mBio 10: e01230-19. |
27 | Park HS, Kim HJ, Han CY, Nah HJ, Choi SS, Kim ES. 2020. Stimulated biosynthesis of an C10-Deoxy Heptaene NPP B2 via regulatory genes overexpression in Pseudonocardia autotrophica. Front. Microbiol. 11: 19. |
28 | Caffrey P, Hogan M, Song Y. 2022. New glycosylated polyene macrolides: refining the ore from genome mining. Antibiotics 11: 334. |