Non-Polar Myxococcus fulvus KYC4048 Metabolites Exert Anti-Proliferative Effects via Inhibition of Wnt/β-Catenin Signaling in MCF-7 Breast Cancer Cells |
Park, Juha
(Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University)
Yoo, Hee-Jin (Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University) Yu, Ah-Ran (Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University) Kim, Hye Ok (Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University) Park, Sang Cheol (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) Jang, Young Pyo (Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University) Lee, Chayul (Lifetogether Co., Ltd.) Choe, Wonchae (Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University) Kim, Sung Soo (Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University) Kang, Insug (Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University) Yoon, Kyung-Sik (Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University) |
1 | Barker N, Clevers H. 2006. Mining the Wnt pathway for cancer therapeutics. Nat. Rev. Drug Discov. 5: 997-1014. DOI |
2 | Rey JP, Ellies DL. 2010. Wnt modulators in the biotech pipeline. Dev. Dyn. 239: 102-114. DOI |
3 | Lee C, Park S, Ayush I, Cho K, Kim SS, Kang I, et al. 2018. Effects of Myxococcus fulvus KYC4048 metabolites on breast cancer cell death. J. Microbiol. Biotechnol. 28: 765-775. DOI |
4 | Weissman KJ, Muller R. 2010. Myxobacterial secondary metabolites: bioactivities and modes-of-action. Nat. Prod. Rep. 27: 1276-1295. DOI |
5 | Bollag DM, McQueney PA, Zhu J, Hensens O, Koupal L, Liesch J, et al. 1995. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res. 55: 2325-2333. |
6 | Gerth K, Bedorf N, Hofle G, Irschik H, Reichenbach H. 1996. Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. J. Antibiot. (Tokyo) 49: 560-563. DOI |
7 | Fumoleau P, Coudert B, Isambert N, Ferrant E. 2007. Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues. Ann. Oncol. 18 Suppl 5: v9-15. DOI |
8 | Gerth K, Pradella S, Perlova O, Beyer S, Muller R. 2003. Myxobacteria: proficient producers of novel natural products with various biological activities--past and future biotechnological aspects with the focus on the genus Sorangium. J. Biotechnol. 106: 233-253. DOI |
9 | Weissman KJ, Muller R. 2009. A brief tour of myxobacterial secondary metabolism. Bioorg. Med. Chem. 17: 2121-2136. DOI |
10 | van Schie EH, van Amerongen R. 2020. Aberrant WNT/CTNNB1 Signaling as a therapeutic target in human breast cancer: Weighing the evidence. Front. Cell Dev. Biol. 8: 25. DOI |
11 | Wang Z, Li B, Zhou L, Yu S, Su Z, Song J, et al. 2016. Prodigiosin inhibits Wnt/beta-catenin signaling and exerts anticancer activity in breast cancer cells. Proc. Natl. Acad. Sci. USA 113: 13150-13155. DOI |
12 | Boonmuen N, Thongon N, Chairoungdua A, Suksen K, Pompimon W, Tuchinda P, et al. 2016. 5-Acetyl goniothalamin suppresses proliferation of breast cancer cells via Wnt/beta-catenin signaling. Eur. J. Pharmacol. 791: 455-464. DOI |
13 | Li X, Meng Y, Xie C, Zhu J, Wang X, Li Y, et al. 2018. Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/beta-catenin pathway. J. Cell Biochem. 119: 4134-4141. DOI |
14 | MacDonald BT, Tamai K, He X. 2009. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17: 9-26. DOI |
15 | Kim HJ, Seo BG, Kim KD, Yoo J, Lee JH, Min BS, et al. 2020. C5, A Cassaine diterpenoid amine, induces apoptosis via the extrinsic pathways in human lung cancer cells and human lymphoma cells. Int. J. Mol. Sci. 21: 1298. DOI |
16 | DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, et al. 2014. Cancer treatment and survivorship statistics, 2014. CA Cancer J. Clin. 64: 252-271. DOI |
17 | Siegel RL, Miller KD, Jemal A. 2017. Cancer Statistics, 2017. CA Cancer J. Clin. 67: 7-30. DOI |
18 | Ghebeh H, Al-Khaldi S, Olabi S, Al-Dhfyan A, Al-Mohanna F, Barnawi R, et al. 2014. Fascin is involved in the chemotherapeutic resistance of breast cancer cells predominantly via the PI3K/Akt pathway. Br. J. Cancer 111: 1552-1561. DOI |
19 | Siegel R, Naishadham D, Jemal A. 2013. Cancer statistics, 2013. CA Cancer J. Clin. 63: 11-30. DOI |
20 | Gao S, Li X, Ding X, Qi W, Yang Q. 2017. Cepharanthine induces autophagy, apoptosis and cell cycle arrest in breast cancer cells. Cell. Physiol. Biochem. 41: 1633-1648. DOI |
21 | Clevers H, Nusse R. 2012. Wnt/beta-catenin signaling and disease. Cell 149: 1192-1205. DOI |
22 | Holland JD, Gyorffy B, Vogel R, Eckert K, Valenti G, Fang L, et al. 2013. Combined Wnt/beta-catenin, Met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome. Cell Rep. 5: 1214-1227. DOI |
23 | Incassati A, Chandramouli A, Eelkema R, Cowin P. 2010. Key signaling nodes in mammary gland development and cancer: beta-catenin. Breast Cancer Res. 12: 213. DOI |
24 | Lu W, Lin C, Roberts MJ, Waud WR, Piazza GA, Li Y. 2011. Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/beta-catenin pathway. PLoS One 6: e29290. DOI |
25 | Bao R, Christova T, Song S, Angers S, Yan X, Attisano L. 2012. Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. PLoS One 7: e48670. DOI |
26 | Xu J, Prosperi JR, Choudhury N, Olopade OI, Goss KH. 2015. beta-Catenin is required for the tumorigenic behavior of triple-negative breast cancer cells. PLoS One 10: e0117097. DOI |
![]() |