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http://dx.doi.org/10.4014/jmb.2107.07024

Latilactobacillus sakei WIKIM31 Decelerates Weight Gain in High-Fat Diet-Induced Obese Mice by Modulating Lipid Metabolism and Suppressing Inflammation  

Park, Sung-Soo (Microbiology and Functionality Research Group, World Institute of Kimchi)
Lim, Seul Ki (Microbiology and Functionality Research Group, World Institute of Kimchi)
Lee, Jieun (SME Service Department, Strategy and Planning Division)
Park, Hyo Kyeong (Microbiology and Functionality Research Group, World Institute of Kimchi)
Kwon, Min-Sung (Microbiology and Functionality Research Group, World Institute of Kimchi)
Yun, Misun (Microbiology and Functionality Research Group, World Institute of Kimchi)
Kim, Namhee (Microbiology and Functionality Research Group, World Institute of Kimchi)
Oh, Young Joon (Microbiology and Functionality Research Group, World Institute of Kimchi)
Choi, Hak-Jong (Microbiology and Functionality Research Group, World Institute of Kimchi)
Publication Information
Journal of Microbiology and Biotechnology / v.31, no.11, 2021 , pp. 1568-1575 More about this Journal
Abstract
Obesity and related metabolic diseases are major problems worldwide. Some probiotics are currently considered potential therapeutic strategies for obesity. We aimed to investigate the anti-obesity efficacy of Latilactobacillus sakei WIKIM31 in obese mice induced by a high fat diet. The administration of a high-fat diet with L. sakei WIKIM31 reduced body weight gain, epididymal fat mass, triglyceride and total cholesterol levels in the blood, and remarkably decreased the expression of lipogenesis-related genes in the epididymal adipose tissue and liver. Interestingly, intake of L. sakei WIKIM31 improved gut barrier function by increasing the gene expression of tight junction proteins and suppressing the inflammatory responses. Additionally, L. sakei WIKIM31 enhanced the production of short-chain fatty acids, such as butyrate and propionate, in the intestinal tract. These results showed that L. sakei WIKIM31 can be used as a potential therapeutic probiotic for obesity.
Keywords
Latilactobacillus sakei WIKIM31; probiotics; obesity; inflammation;
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