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http://dx.doi.org/10.4014/jmb.2107.07023

Lagerstroemia ovalifolia Exerts Anti-Inflammatory Effects in Mice of LPS-Induced ALI via Downregulating of MAPK and NF-κB Activation  

Min, Jae-Hong (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Kim, Seong-Man (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Park, JI-Won (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Kwon, Nam Hoon (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Goo, Soo Hyeon (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Ngatinem, Ngatinem (Starch Technology Center, Agency for the Assessment and Application Technology)
Ningsih, Sri (Center for Pharmaceutical and Medical Technology, Agency for the Assessment and Application of Technology)
Paik, Jin-Hyub (International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology)
Choi, Sangho (International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology)
Oh, Sei-Ryang (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Han, Sang-Bae (College of Pharmacy, Chungbuk National University)
Ahn, Kyung-Seop (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Lee, Jae-Won (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Publication Information
Journal of Microbiology and Biotechnology / v.31, no.11, 2021 , pp. 1501-1507 More about this Journal
Abstract
Lagerstroemia ovalifolia Teijsm. & Binn. (LO) (crape myrtle) has reportedly been used as traditional herbal medicine (THM) in Java, Indonesia. Our previous study revealed that the LO leaf extract (LOLE) exerted anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Based on this finding, the current study aimed to evaluate the protective effects of LOLE in a mouse model of LPS-induced acute lung injury (ALI). The results showed that treatment with LPS enhanced the inflammatory cell influx into the lungs and increased the number of macrophages and the secretion of the inflammatory cytokines in the bronchoalveolar lavage fluid (BALF) of mice. However, these effects were notably abrogated with LOLE pretreatment. Furthermore, the increase of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and monocyte chemoattractant protein-1 (MCP-1) expression in the lung tissues of mice with ALI was also reversed by LOLE. In addition, LOLE significantly suppressed the LPS-induced activation of the MAPK/NF-κB signaling pathway and led to heme oxygenase-1 (HO-1) induction in the lungs. Additionally, in vitro experiments showed that LOLE enhanced the expression of HO-1 in RAW264.7 macrophages. The aforementioned findings collectively indicate that LOLE exerts an ameliorative effect on inflammatory response in the airway of ALI mice.
Keywords
Acute lung injury; Lagerstroemia ovalifolia leaf extract; cytokines; $NF-{\kappa}B$; HO-1;
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