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http://dx.doi.org/10.4014/jmb.1912.12014

IL-10 Expression-Inducing Gut Bacteria Alleviate High-Fat Diet-Induced Obesity and Hyperlipidemia in Mice  

Kim, Hye-In (Department of Food and Nutrition, Kyung Hee University)
Yun, Soo-Won (Department of Food and Nutrition, Kyung Hee University)
Han, Myung Joo (Department of Food and Nutrition, Kyung Hee University)
Jang, Se-Eun (Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, Kyung Hee University)
Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Sciences and Department of Pharmacy, Kyung Hee University)
Publication Information
Journal of Microbiology and Biotechnology / v.30, no.4, 2020 , pp. 599-603 More about this Journal
Abstract
In the present study, we examined the effects of interleukin (IL)-10 expression-inducing bacteria Bifidobacterium adolescentis HP1, Lactobacillus mucosae HP2, and Weissella cibaria HP3 on high-fat diet (HFD)-induced obesity and liver steatosis in mice. Oral gavage of HP1, HP2, and HP3 reduced HFD-induced bodyweight gain, triglycerides, and total cholesterol levels in the blood and liver. They also suppressed HFD-induced colitis and the fecal δ,γ-Proteobacteria population. Of the tested bacteria, HP2, which most potently inhibited IL-10 expression, also suppressed HFD-induced bodyweight gain, liver steatosis, and colitis most effectively. These findings suggest that IL-10 expression-inducing gut bacteria can suppress obesity and liver steatosis.
Keywords
Gut bacteria; IL-10; obesity; liver steatosis; colitis;
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