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http://dx.doi.org/10.4014/jmb.1911.11019

Potential Health-Promoting Benefits of Paraprobiotics, Inactivated Probiotic Cells  

Akter, Shahina (Department of Food Science and Biotechnology, College of BioNano Technology, Gachon University)
Park, Jong-Hyun (Department of Food Science and Biotechnology, College of BioNano Technology, Gachon University)
Jung, Hoo Kil (Department of Food Science and Biotechnology, College of BioNano Technology, Gachon University)
Publication Information
Journal of Microbiology and Biotechnology / v.30, no.4, 2020 , pp. 477-481 More about this Journal
Abstract
Viability plays an important role in the beneficial microbes (probiotics) to produce health benefits. However, this idea has been changed after the invention of the term "paraprobiotics," indicating that non-viable microbes could produce health benefits similar to those produced by live probiotics. Occasionally, it might be dangerous to administer live probiotics to people with weak immunity. In such cases, ingestion of paraprobiotics could be a potential alternative. The definition of paraprobiotics refers to the use of inactivated (non-viable) microbial cells or cell fractions to provide health benefits to the consumer. Paraprobiotics have attracted much attention because of their long shelf life, safety, and beneficial effects, such as modulation of immunity, modification of biological responses, reduction of cholesterol, anti-inflammatory, and antiproliferative properties. These features indicate that paraprobiotics may play a vital role in improving the health of the consumer by enhancing particular physiological functions, even though the exact underlying mechanisms have not yet been completely elucidated. In this mini-review, we briefly discuss the historical backgrounds of paraprobiotics and evidence of their health-promoting effects, prophylactic, and therapeutic properties.
Keywords
Paraprobiotics; inactivated (non-viable); health benefits; technological feasibilities; biological response modifier;
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1 Matsuguchi T, Takagi A, Matsuzaki T, Nagaoka M, Ishikawa K, Yokokura T, et al. 2003. Lipoteichoic acids from Lactobacillus strains elicit strong tumor necrosis factor a-inducing activities in macrophages through Toll-like receptor 2. Clin. Diagn. Lab. Immunol. 10: 259-266.   DOI
2 Salinas I, Meseguer J, Esteban A. 2008. Antiproliferative effects and apoptosis induction by probiotic cytoplasmic extracts in fish cell lines. Vet. Microbiol. 126: 287-294.   DOI
3 Shigwedha N, Zhang L, Sichel L, Jia L, Gong P, Liu W, et al. 2014b. More than a few LAB alleviate common allergies: Impact of paraprobiotics in comparison to probiotical live cells. J. Biosci. Med. 2: 56-64.   DOI
4 Taverniti V, Guglielmetti S. 2011. The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: Proposal of paraprobiotic concept). Genes Nutr. 6: 261-274.   DOI
5 de Almada CN, Almada CN, Martinez CRR, SantAna AS. 2016. Paraprobiotics: evidences on their ability to modify biological responses, inactivation methods and perspectives on their application in foods. Trends Food Sci. Technol. 58: 96-114.   DOI
6 Aguilar-Toala JE, Garcia-Varela R, Garcia HS, Mata-Haro V, Gonzalez-Cordova AF, Vallejo-Cordoba B, et al. 2018. Postbiotics: An evolving term within the functional foods field. Trends. Food Sci. Technol. 75: 105-114.   DOI
7 Adams CA. 2010. The probiotic paradox: Live and dead cells are biological response modifiers. Nutr. Res. Rev. 23: 37-46.   DOI
8 Lien E, Ingalls RR. 2002. Toll-like receptors. Crit. Care Med. 30: S1-S11.   DOI
9 Shimosato T, Kitazawa H. 2013. Immunogenics: Immunostimulatory oligodeoxynucleotides from probiotics. In: Kitazawa H, Villena J, Alvarez S. Eds., Probiotics: Immunobiotics and Immunogenics, CRC Press, Boca Raton. pp. 336-350. http://dx.doi.org/10.1201/b15532-14.
10 Shigwedha N, Sichel L, Jia L, Zhang L. 2014a. Probiotical cell fragments (PCFs) as novel nutraceutical ingredients. J. Biosci. Med. 2: 43-55.
11 Amrouche T, Boutin Y, Fliss I. 2006. Effects of bifidobacterial cytoplasm peptide and protein fractions on mouse lymphocyte proliferation and cytokine production. Food Agr. Immunol. 17: 29-42.   DOI
12 Shimosato T, Kimura T, Tohno M, Dimitrov II, Katoh S, Ito Y, et al. 2006. Strong immunostimulatory activity of AToligodeoxynucleotide requires a six-base loop with a self-stabilized 5?-C…G-3? stem structure. Cell. Microbiol. 8(3): 485-495.
13 Erickson KL, Hubbard NE. 2000. Probiotic immunomodulation in health and disease. J. Nutr. 130(2S Suppl): 403S-409S.   DOI
14 Sashihara T, Sueki N, Ikegami S. 2006. An analysis of the effectiveness of heat-killed LAB in alleviating allergic diseases. J. Dairy Sci. 89: 2846-2855.   DOI
15 Thakur BK, Saha P, Banik G, Saha DR, Grover S, Batish VK, et al. 2016. Live and heat-killed probiotic Lactobacillus casei Lbs2 protects from experimental colitis through Toll-like receptor 2-dependent induction of T-regulatory response. Int. Immunopharmacol. 36: 39-50.   DOI
16 Kankaanpaa P, Sutasb Y, Salminena S, Isolaurib E. 2003. Homogenates derived from probiotic bacteria provide down-regulatory signals for peripheral blood mononuclear cells. Food Chem. 83: 269-277.   DOI
17 Ryu YH, Baik JE, Yang JS, Kang SS, Im J, Yun CH, et al. 2009. Differential immunostimulatory effects of Gram-positive bacteria due to their lipoteichoic acids. Int. Immunopharmacol. 9: 127-133.   DOI
18 Makino S, Ikegami S, Kano H, Sashihara T, Sugano H, Horiuchi H, et al. 2006. Immunomodulatory effects of polysaccharides produced by Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1. J. Dairy Sci. 89: 2873-2881.   DOI
19 Sarkar S. 2016. Efficacy of dead probiotic cells. Int. J. Food Sci. Nutr. Diet. 5(2e): 1.
20 Bajpai VK, Chandra V, Kim NH, Rai R, Kumar P, Kim K, et al. 2017. Ghost probiotics with a combined regimen: A novel therapeutic approach against the Zika virus, an emerging world threat. Crit. Rev. Biotechnol. 38: 438-454.   DOI
21 Salminen S, Ouwehand A, Benno Y, Lee YK. 1999. Probiotics: How should they be defined? Trends Food Sci. Technol. 10: 107-110.   DOI
22 Mitsuoka T. 2014. Development of functional foods. Biosci. Microbiota Food Health 33: 117-128.   DOI
23 Middelbos IS, Godoy MR, Fastinger ND, Fahey GC. 2007. A dose-response evaluation of spray-dried yeast cell wall supplementation of diets fed to adult dogs: Effects on nutrient digestibility, immune indices, and fecal microbial populations. J. Anim. Sci. 85: 3022-3032.   DOI
24 Posadas GA, Broadway PR, Thornton JA, Carroll JA, Lawrence A, Corley JR, et al. 2017. Yeast pro- and paraprobiotics have the capability to bind pathogenic bacteria associated with animal disease. Transl. Anim. Sci. 1: 60-68.   DOI
25 Jijon H, Backer J, Diaz H, Yeung H, Thiel D, McKaigney C, et al. 2004. DNA from probiotic bacteria modulates murine and human epithelial and immune function. Gastroenterology 126: 1358-1373.   DOI
26 Petrof EO, Kojima K, Ropeleski MJ, Musch MW, Tao Y, De Simone C, Chang EB. 2004. Probiotics inhibit nuclear factor-kappa-B and induce heat shock proteins in colonic epithelial cells through proteasome inhibition. Gastroenterology 127:1474-1487.   DOI
27 Cross ML, Gill HS. 2001. Can immunoregulatory LAB be used as dietary supplements to limit allergies? Int. Arch. Allergy Immunol. 125: 112-119.   DOI
28 Hopkins PA, Sriskandan S. 2005. Mammalian Toll-like receptors: To immunity and beyond. Clin. Exp. Immunol. 140: 395-407.   DOI
29 Kimoto-Nira H. 2018. New LAB for skin health via oral intake of heat-killed or live cells. Anim. Sci. J. 89: 835-842.   DOI
30 Sasaki E, Suzuki S, Fukui Y, Yajima N. 2015. Cell-bound exopolysaccharides of Lactobacillus brevis KB290 enhance cytotoxic activity of mouse splenocytes. J. Appl. Microbiol. 118: 506-514.   DOI
31 Sawada D, Sugawara T, Ishida Y, Aihara K, Aoki Y, Takehara I, et al. 2016. Effect of continuous ingestion of a beverage prepared with Lactobacillus gasseri CP2305 inactivated by heat treatment on the regulation of intestinal function. Food Res. Int. 79: 33-39.   DOI
32 Tanzer JM, Thompson A, Lang C, Cooper B, Hareng L, Gamer A, et al. 2010. Caries inhibition by and safety of Lactobacillus paracasei DSMZ16671. J. Dental Res. 89: 921-926.   DOI
33 Sugawara T, Sawada D, Ishida Y, Aihara K, Aoki Y, Takehara I, et al. 2016. Regulatory effect of paraprobiotic Lactobacillus gasseri CP2305 on gut environment and function. Microb. Ecol. Health Dis. 27: 30259-30269.
34 Serin Y, Andruskiene J. 2017. New perspective for functional component of foods: Paraprobiotics. International Conference - Biomedical and Social Sciences: Education, Research and Innovation 2017. Klaipeda State University of Applied Science Faculty of Health Science. pp. 30-32. 11th of April, Klaipeda.