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http://dx.doi.org/10.4014/jmb.2006.06042

The Anti-Inflammatory Effect of Trichilia martiana C. DC. in the Lipopolysaccharide-Stimulated Inflammatory Response in Macrophages and Airway Epithelial Cells and in LPS-Challenged Mice  

Park, Ji-Won (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Ryu, Hyung Won (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Ahn, Hye In (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Min, Jae-Hong (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Kim, Seong-Man (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Kim, Min-Gu (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Kwon, Ok-Kyoung (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Hwang, Daseul (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Kim, Soo-Yong (International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology)
Choi, Sangho (International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology)
Zamora, Nelson (Bioprospecting Research Unit, National Biodiversity Institute)
Rosales, Kattia (Bioprospecting Research Unit, National Biodiversity Institute)
Oh, Sei-Ryang (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Lee, Jae-Won (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Ahn, Kyung-Seop (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology)
Publication Information
Journal of Microbiology and Biotechnology / v.30, no.11, 2020 , pp. 1614-1625 More about this Journal
Abstract
A number of species of the genus Trichilia (Meliaceae) exhibit anti-inflammatory effects. However, the effect of Trichilia martiana C. DC. (TM) on lipopolysaccharide (LPS)-induced inflammation has not, to the best of our knowledge, yet been determined. Therefore, in the present study, the antiinflammatory effect of TM on LPS-stimulated RAW264.7 macrophages was evaluated. The ethanol extract of TM (TMEE) significantly inhibited LPS-induced nitric oxide (NO), prostaglandin 2 (PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). TMEE also reduced the levels of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β and IL-6. The upregulation of mitogen-activated protein kinases (MAPKs) and NF-κB activation was revealed to be downregulated following TMEE pretreatment. Furthermore, TMEE was indicated to lead to the nucleus translocation of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and the expression of heme oxygenase-1 (HO-1). In H292 airway epithelial cells, the pretreatment of TMEE significantly downregulated the production of LPS-stimulated IL-1β, and TMEE was indicated to increase the expression of HO-1. In animal models exhibiting LPS-induced acute lung injury (ALI), treatment with TMEE reduced the levels of macrophages influx and TNF-α production in the bronchoalveolar lavage fluid (BALF) of ALI mice. Additionally, TMEE significantly downregulated the activation of ERK, JNK and IκB, and upregulated the expression of HO-1 in the lungs of ALI mice. In conclusion, the results of the current study demonstrated that TMEE could exert a regulatory role in the prevention or treatment of the endotoxin-mediated inflammatory response.
Keywords
Trichilia martiana C. DC; macrophage; inflammatory molecules; airway inflammation; NF-${\kappa}B$; acute lung injury;
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