Browse > Article
http://dx.doi.org/10.4014/jmb.1910.10059

Identification of Hepatitis E Virus in Bovine and Porcine Raw Livers  

Go, Hyeon-Jeong (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University)
Park, Byung-Joo (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University)
Ahn, Hee-Seop (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University)
Lyoo, Eu-Lim (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University)
Kim, Dong-Hwi (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University)
Lee, Joong-Bok (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University)
Park, Seung-Yong (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University)
Song, Chang-Seon (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University)
Lee, Sang-Won (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University)
Choi, In-Soo (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University)
Publication Information
Journal of Microbiology and Biotechnology / v.29, no.12, 2019 , pp. 2022-2025 More about this Journal
Abstract
Several animal species including pigs are directly involved in the zoonotic transmission of the hepatitis E virus (HEV) to humans. This study was conducted to detect HEV in bovine and porcine raw livers by nested reverse transcription-polymerase chain reaction. Zoonotic HEV strains were identified in 1.0 and 3.0% of the tested bovine and porcine livers, respectively. HEV-4 was detected in the bovine livers, but both HEV-3 and HEV-4 were identified in the porcine livers. These results indicate that zoonotic transmission of HEV may occur via consumption of raw or undercooked livers of pigs and cattle.
Keywords
HEV-3; HEV-4; pigs; cattle; liver;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 Tam AW, Smith MM, Guerra ME, Huang CC, Bradley DW, Fry KE, et al. 1991. Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome. Virology 185: 120-131.   DOI
2 Kang S, Myoung J. 2017. Host innate immunity against Hepatitis E virus and viral evasion mechanisms. J. Microbiol. Biotechnol. 27: 1727-1735.   DOI
3 Jilani N, Das BC, Husain SA, Baweja UK, Chattopadhya D, Gupta RK, et al. 2007. Hepatitis E virus infection and fulminant hepatic failure during pregnancy. J. Gastroen. Hepatol. 22: 676-682.   DOI
4 Myoung J, Min KS. 2019. Dose-dependent inhibition of melanoma differentiation-associated gene 5-Mediated activation of type I interferon responses by methyltransferase of Hepatitis E Virus. J. Microbiol. Biotechnol. 29: 1137-1143.   DOI
5 Kang S, Choi C, Choi I, Han KN, Roh SW, Choi J, et al. 2018. Hepatitis E virus methyltransferase inhibits type I interferon induction by targeting RIG-I. J. Microbiol. Biotechnol. 28: 1554-1562.   DOI
6 Kim YH, Park BJ, Ahn HS, Han SH, Go HJ, Kim DH, et al. 2018. Detection of hepatitis E virus genotypes 3 and 4 in pig farms in Korea. J. Vet. Sci. 19: 309-312.   DOI
7 Lee SH, Kang SC, Kim DY, Bae JH, Kim JH. 2007. Detection of swine hepatitis E virus in the porcine hepatic lesion in Jeju Island. J. Vet. Sci. 8: 51-55.   DOI
8 Forgach P, Nowotny N, Erdelyi K, Boncz A, Zentai J, Szucs G, et al. 2010. Detection of Hepatitis E virus in samples of animal origin collected in Hungary. Vet. Microbiol. 143: 106-116.   DOI
9 Prpic J, Cerni S, Skoric D, Keros T, Brnic D, Cvetnic Z, et al. 2015. Distribution and molecular characterization of hepatitis E virus in domestic animals and wildlife in Croatia. Food Environ. Virol. 7: 195-205.   DOI
10 Takahashi H, Tanaka T, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, et al. 2012. A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food. Arch. Virol. 157: 235-246.   DOI
11 Meng XJ, Purcell RH, Halbur PG, Lehman JR, Webb DM, Tsareva TS, et al. 1997. A novel virus in swine is closely related to the human hepatitis E virus. Proc. Natl. Acad. Sci. USA 94: 9860-9865.   DOI
12 Wang YC, Zhang HY, Li Z, Gu WJ, Lan HY, Hao W, et al. 2001. Detection of sporadic cases of hepatitis e virus (HEV) infection in china using immunoassays based on recombinant open reading frame 2 and 3 polypeptides from HEV genotype 4. J. Clin. Microbiol. 39: 4370-4379.   DOI
13 Bouwknegt M, Lodder-Verschoor F, Van Der Poel WHM, Rutjes SA, De Roda Husman AM. 2007. Hepatitis E virus RNA in commercial porcine livers in the Netherlands. J. Food Protect. 70: 2889-2895.   DOI
14 Lee GH, Tan BH, Teo ECY, Lim SG, Dan YY, Wee A, et al. 2016. Chronic infection with camelid hepatitis E virus in a liver transplant recipient who regularly consumes camel meat and milk. Gastroenterology 150: 355-377.   DOI
15 Tei S, Kitajima N, Takahashi K, Mishiro S. 2003. Zoonotic transmission of hepatitis E virus from deer to human beings. Lancet 362: 371-373.   DOI
16 Yazaki Y, Mizuo H, Takahashi M, Nishizawa T, Sasaki N, Gotanda Y, et al. 2003. Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food. J. Gen. Virol. 84: 2351-2357.   DOI
17 Takahashi K, Kitajima N, Abe N, Mishiro S. 2004. Complete or near-complete nucleotide sequences of hepatitis E virus genome recovered from a wild boar, a deer, and four patients who ate the deer. Virology 330: 501-505.   DOI
18 Jung K, Kang B, Song DS, Chae C. 2007. Prevalence and genotyping of hepatitis E virus in swine population in Korea between 1995 and 2004: A retrospective study. Vet. J. 173: 683-687.   DOI
19 Jeong SH, Park BJ, Kim YH, Choi YS, Ahn HS, Han SH, et al. 2017. Isolation of hepatitis E virus genotype 4 from patients with acute cryptogenic hepatitis in Korea. J. Clin. Virol. 89: 10-13.   DOI
20 Ahn JM, Kang SG, Lee DY, Shin SJ, Yoo HS. 2005. Identification of novel human hepatitis E virus (HEV) isolates and determination of the seroprevalence of HEV in Korea. J. Clin. Microbiol. 43: 3042-3048.   DOI
21 Huang F, Li YL, Yu WH, Jing SR, Wang J, Long FY, et al. 2016. Excretion of infectious hepatitis E virus into milk in cows imposes high risks of zoonosis. Hepatology 64: 350-359.   DOI
22 Yan BY, Zhang L, Gong LF, Lv JJ, Feng Y, Liu JY, et al. 2016. Hepatitis E virus in yellow cattle, Shandong, Eastern China. Emerg. Infect. Dis. 22: 2211-2212.   DOI
23 Hu GD, Ma X. 2010. Detection and sequences analysis of bovine hepatitis E virus RNA in Xinjiang autonomous region. Bing Du Xue Bao 26: 27-32.
24 Li TC, Chijiwa K, Sera N, Ishibashi T, Etoh Y, Shinohara Y, et al. 2005. Hepatitis E virus transmission from wild boar meat. Emerg. Infect. Dis. 11: 1958-1960.   DOI
25 Wenzel JJ, Preiss J, Schemmerer M, Huber B, Plentz A, Jilg W. 2011. Detection of hepatitis E virus (HEV) from porcine livers in Southeastern Germany and high sequence homology to human HEV isolates. J. Clin. Virol. 52: 50-54.   DOI
26 Reuter G, Fodor D, Forgach P, Katai A, Szucs G. 2009. Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary. J. Clin. Virol. 44: 277-281.   DOI
27 Feagins AR, Opriessnig T, Guenette DK, Halbur PG, Meng XJ. 2007. Detection and characterization of infectious Hepatitis E virus from commercial pig livers sold in local grocery stores in the USA. J. Gen. Virol. 88: 912-917.   DOI