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http://dx.doi.org/10.4014/jmb.1910.10004

Beyond Viral Interferon Regulatory Factors: Immune Evasion Strategies  

Myoung, Jinjong (Korea Zoonosis Research Institute, Genetic Engineering Research Institute and Department of Bioactive Material Science, College of Natural Science, Jeonbuk National University)
Lee, Shin-Ae (Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California)
Lee, Hye-Ra (Department of Biotechnology and Bioinformatics, College of Science and Technology, Korea University)
Publication Information
Journal of Microbiology and Biotechnology / v.29, no.12, 2019 , pp. 1873-1881 More about this Journal
Abstract
The innate immune response serves as a first-line-of-defense mechanism for a host against viral infection. Viruses must therefore subvert this anti-viral response in order to establish an efficient life cycle. In line with this fact, Kaposi's sarcoma-associated herpesvirus (KSHV) encodes numerous genes that function as immunomodulatory proteins to antagonize the host immune system. One such mechanism through which KSHV evades the host immunity is by encoding a viral homolog of cellular interferon (IFN) regulatory factors (IRFs), known as vIRFs. Herein, we summarize recent advances in the study of the immunomodulatory strategies of KSHV vIRFs and their effects on KSHV-associated pathogenesis.
Keywords
KSHV; viral interferon regulatory factor; immune evasion strategy; PRR-mediated signaling pathway; apoptosis pathway;
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