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http://dx.doi.org/10.4014/jmb.1812.12002

Immunomodulatory Effects by Bifidobacterium longum KACC 91563 in Mouse Splenocytes and Macrophages  

Choi, Mijoo (Department of Food and Nutrition, Kyungnam University)
Lee, Yunjung (Department of Food and Nutrition, Kyungnam University)
Lee, Na-Kyoung (Department of Food Science and Biotechnology of Animal Resources, Konkuk University)
Bae, Chun Ho (Aram Co., Ltd.)
Park, Dae Chul (Aram Co., Ltd.)
Paik, Hyun-Dong (Department of Food Science and Biotechnology of Animal Resources, Konkuk University)
Park, Eunju (Department of Food and Nutrition, Kyungnam University)
Publication Information
Journal of Microbiology and Biotechnology / v.29, no.11, 2019 , pp. 1739-1744 More about this Journal
Abstract
The present study evaluates the immunomodulatory effect of Bifidobacterium longum KACC 91563 in murine primary splenocytes and macrophages. B. longum KACC 91563 regulated T- and B-cell proliferation and inhibited the Th1 (IL-2, IFN-γ)/Th2 (IL-4, IL-10) cytokine imbalance and immune cytokine production. Moreover, immunoglobulin E (IgE) levels were significantly lower after treatment with B. longum KACC 91563. These findings suggest that B. longum KACC 91563 could modulate the systemic immune system toward both IgE production and regulation of the Th1/Th2 balance.
Keywords
Bifidobacterium longum KACC 91563; cytokine; immunomodulatory effect; Th1/Th2 balance;
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