Generation and Characterization of a Neutralizing Human Monoclonal Antibody to Hepatitis B Virus PreS1 from a Phage-Displayed Human Synthetic Fab Library |
Jo, Gyunghee
(Department of Systems Immunology, College of Biomedical Science, Kangwon National University)
Jeong, Mun Sik (Department of Systems Immunology, College of Biomedical Science, Kangwon National University) Wi, Jimin (Scripps Korea Antibody Institute) Kim, Doo Hyun (Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University) Kim, Sangkyu (Department of Systems Immunology, College of Biomedical Science, Kangwon National University) Kim, Dain (Department of Systems Immunology, College of Biomedical Science, Kangwon National University) Yoon, Jun-Yeol (Department of Systems Immunology, College of Biomedical Science, Kangwon National University) Chae, Heesu (Department of Systems Immunology, College of Biomedical Science, Kangwon National University) Kim, Kyun-Hwan (Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University) Hong, Hyo Jeong (Department of Systems Immunology, College of Biomedical Science, Kangwon National University) |
1 | WHO. 2017. Global Hepatitis Report 2017. World Health Organization, Geneva, Switzerland. |
2 | Sunbul M. 2014. Hepatitis B virus genotypes: global distribution and clinical importance. World J. Gastroenterol. 20: 5427. DOI |
3 | Ganem D, Prince AM. 2004. Hepatitis B virus infection - natural history and clinical consequences. N. Engl. J. Med. 350: 1118-1129. DOI |
4 | Huang C-F, Lin S-S, Ho Y-C, Chen F-L, Yang C-C. 2006. The immune response induced by hepatitis B virus principal antigens. Cell. Mol. Immunol. 3: 97-106. |
5 | Schulze A, Schieck A, Ni Y, Mier W, Urban S. 2010. Fine mapping of pre-S sequence requirements for hepatitis B virus large envelope protein-mediated receptor interaction. J. Virol. 84: 1989-2000. DOI |
6 | Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, et al. 2012. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife 1: e00049. DOI |
7 | Wei J, Wang Y-Q, Lu Z-M, Li G-D, Wang Y, Zhang Z-C. 2002. Detection of anti-preS1 antibodies for recovery of hepatitis B patients by immunoassay. World J. Gastroenterol. 8: 276. DOI |
8 | Kim JH, Gripon P, Bouezzedine F, Jeong MS, Chi S-W, Ryu S-E, et al. 2015. Enhanced humanization and affinity maturation of neutralizing anti-hepatitis B virus preS1 antibody based on antigen-antibody complex structure. FEBS Lett. 589: 193-200. DOI |
9 | Wi J, Jeong MS, Hong HJ. 2017. Construction and characterization of an anti-hepatitis B virus preS1 humanized antibody that binds to the essential receptor binding site. J. Microbiol. Biotechnol. 27: 1336-1344. DOI |
10 | Maeng C-Y, Ryu CJ, Gripon P, Guguen-Guillouzo C, Hong HJ. 2000. Fine mapping of virus-neutralizing epitopes on hepatitis B virus preS1. Virology 270: 9-16. DOI |
11 | Hong HJ, Ryu CJ, Hur H, Kim S, Oh HK, Oh MS, et al. 2004. In vivo neutralization of hepatitis B virus infection by an anti-preS1 humanized antibody in chimpanzees. Virology 318: 134-141. DOI |
12 | Heermann K, Goldmann U, Schwartz W, Seyffarth T, Baumgarten H, Gerlich W. 1984. Large surface proteins of hepatitis B virus containing the pre-S sequence. J. Virol. 52: 396-402. DOI |
13 | Pizarro JC, Vulliez-le Normand B, Riottot M-M, Budkowska A, Bentley GA. 2001. Structural and functional characterization of a monoclonal antibody specific for the preS1 region of hepatitis B virus. FEBS Lett. 509: 463-468. DOI |
14 | Maeng C-Y, Oh MS, Park IH, Hong HJ. 2001. Purification and structural analysis of the hepatitis B virus preS1 expressed from Escherichia coli. Biochem. Biophys. Res. Commun. 282: 787-792. DOI |
15 | Zhang P, Yu WMY, Venable R, Alter HJ, Shih JW-K. 2006. Neutralization epitope responsible for the hepatitis B virus subtype-specific protection in chimpanzees. Proc. Natl. Acad. Sci. USA 103: 9214-9219. DOI |
16 | Kim HS, Hong HJ. 1995. Efficient expression, purification and characterization of hepatitis B virus preS1 protein from Escherichia coli. Biotechnol. Lett. 17: 871-876. DOI |
17 | Kontermann R, Dubel S. 2010. Antibody Engineering. Vol. 2. Springer, Berlin/Heidelberg. |
18 | Yoon J-Y, Kim D-H, Kim S, Kim D, Jo G, Shin M-S, et al. 2017. Generation of a monoclonal antibody that has reduced binding activity to VX-inactivated butyrylcholinesterase (BuChE) compared to BuChE by phage display. Biotechnol. Bioprocess Eng. 22: 114-119. DOI |
19 | Backliwal G, Hildinger M, Hasija V, Wurm FM. 2008. Highdensity transfection with HEK-293 cells allows doubling of transient titers and removes need for a priori DNA complex formation with PEI. Biotechnol. Bioeng. 99: 721-727. DOI |
20 | Park YK, Park E-S, Kim DH, Ahn SH, Park SH, Lee AR, et al. 2016. Cleaved c-FLIP mediates the antiviral effect of TNF- against hepatitis B virus by dysregulating hepatocyte nuclear factors. J. Hepatol. 64: 268-277. DOI |
21 | Zhang T-Y, Yuan Q, Zhao J-H, Zhang Y-L, Yuan L-Z, Lan Y, et al. 2015. Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen. Gut 65: 658-671. |
22 | Ryu CJ, Gripon P, Park HR, Park SS, Kim YK, Guguen- Guillouzo C, et al. 1997. In vitro neutralization of hepatitis B virus by monoclonal antibodies against the viral surface antigen. J. Med. Virol. 52: 226-233. DOI |
23 | Southern EM. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98: 503-517. DOI |