[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4014/jmb.1703.03060

(E)-2-Methoxy-4-(3-(4-Methoxyphenyl)Prop-1-en-1-yl)Phenol Induces Apoptosis in HeLa Cervical Cancer Cells via the Extrinsic Apoptotic Pathway

Park, Chan-Woo (Department of Bioscience and Biotechnology, Konkuk University)
Song, Yong-Seok (Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health)
Lee, Hee Pom (College of Pharmacy and Medical Research Center, Chungbuk National University)
Hong, Jin Tae (College of Pharmacy and Medical Research Center, Chungbuk National University)
Yoon, Do-Young (Department of Bioscience and Biotechnology, Konkuk University)

Publication Information

Journal of Microbiology and Biotechnology / v.27, no.7, 2017 , pp. 1359-1366 More about this Journal

Abstract

(E)-2-Methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol (MMPP), derived from butenal, is a recently synthesized Maillard reaction product. Owing to its novelty, little is known about the function of MMPP. In this study, we elucidated the effects of MMPP on apoptosis in cervical cancer by using the HeLa cervical cancer cell line, which is widely used in cancer research. We observed that MMPP was cytotoxic to HeLa cells and induced activation of caspase-3, -8, and -9, without affecting the expression of the viral oncogenes E6 and E7. In particular, the expression of the death receptors DR5 and FAS was significantly increased by MMPP treatment. There were no significant alterations of mitochondrial intrinsic factors. Taking all these results together, our findings show that MMPP primarily induces apoptosis in HeLa cervical cancer cells via the extrinsic apoptotic signaling pathway, accompanied by an enhanced expression of death receptors.

Keywords

MMPP; (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol; apoptosis; cervical cancer; HeLa;

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Times Cited By KSCI : 1 (Citation Analysis)

Reference
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