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http://dx.doi.org/10.4014/jmb.1611.11023

Prebiotic Effects of Poly-Gamma-Glutamate on Bacterial Flora in Murine Gut  

Jin, Hee-Eun (Department of Bio and Fermentation Convergence Technology, Kookmin University)
Choi, Jae-Chul (Department of Bio and Fermentation Convergence Technology, Kookmin University)
Lim, Yong Taik (SKKU Advanced Institute of Nanotechnology, School of Chemical Engineering, Sungkyunkwan University)
Sung, Moon-Hee (Department of Bio and Fermentation Convergence Technology, Kookmin University)
Publication Information
Journal of Microbiology and Biotechnology / v.27, no.2, 2017 , pp. 412-415 More about this Journal
Abstract
Prebiotics improve the growth or activities of specific microbial genera and species in the gut microbiota in order to confer health benefits to the host. In this study, we investigated the effect of poly-gamma-glutamate (${\gamma}-PGA$) as a prebiotic on the gut microbiota of mice and the organ distributions of ${\gamma}-PGA$ in mice. Pyrosequencing analysis for 16S rRNA genes of bacteria indicated that oral administration of ${\gamma}-PGA$ increased the abundance of Lactobacillales while reducing the abundance of Clostridiales in murine guts. It is suggested that oral administration of ${\gamma}-PGA$ can be helpful for modulating the gut microbiota as a prebiotic.
Keywords
$Poly-{\gamma}-glutamate$; gut microbiota; prebiotics; organ distributions;
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