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http://dx.doi.org/10.4014/jmb.1610.10050

Protective Effects of Standardized Siegesbeckia glabrescens Extract and Its Active Compound Kirenol against UVB-Induced Photoaging through Inhibition of MAPK/NF-κB Pathways  

Kim, Jongwook (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University)
Kim, Mi-Bo (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University)
Yun, Jun Gon (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University)
Hwang, Jae-Kwan (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University)
Publication Information
Journal of Microbiology and Biotechnology / v.27, no.2, 2017 , pp. 242-250 More about this Journal
Abstract
Anti-photoaging effects of standardized Siegesbeckia glabrescens extract (SGE) and its major active compound kirenol were investigated using Hs68 human dermal fibroblasts and hairless mice, respectively. UVB-irradiated hairless mice that received oral SGE (600 mg/kg/day) showed reduced wrinkle formation and skinfold thickness compared with the UVB-irradiated control. Furthermore, SGE treatment increased the mRNA levels of collagen synthesis genes (COL1A1, COL3A1, COL4A1, and COL7A1) and activated antioxidant enzyme (catalase), while suppressing matrix metalloproteinase (MMP-2, -3, -9, and -13) expression. In Hs68 fibroblasts, kirenol also significantly suppressed MMP expression while increasing the expression of COL1A1, COL3A1, and COL7A1. Collectively, our data demonstrate that both SGE and kirenol attenuated UVB-induced photoaging in hairless mice and fibroblasts through inhibition of the mitogen-activated protein kinases and nuclear factor kappa B pathways, suggesting that SGE has potential to serve as a natural anti-photoaging nutraceutical.
Keywords
Kirenol; $MAPK/NF-{\kappa}B$ pathways; photoaging; Siegesbeckia glabrescens;
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