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http://dx.doi.org/10.4014/jmb.1601.01057

Effect of Polylysine on Scrapie Prion Protein Propagation in Spleen during Asymptomatic Stage of Experimental Prion Disease in Mice  

Titlow, William B. (Sander-Brown Center on Aging, College of Medicine, University of Kentucky)
Waqas, Muhammad (Department of Pharmacy, College of Pharmacy, Hanyang University)
Lee, Jihyun (Department of Pharmacy, College of Pharmacy, Hanyang University)
Cho, Jae Youl (Department of Genetic Engineering, Sungkyunkwan University)
Lee, Sang Yeol (Department of Life Science, Gachon University)
Kim, Dae-Hwan (Institute of Pharmaceutical Technology, Hanyang University)
Ryou, Chongsuk (Sander-Brown Center on Aging, College of Medicine, University of Kentucky)
Publication Information
Journal of Microbiology and Biotechnology / v.26, no.9, 2016 , pp. 1657-1660 More about this Journal
Abstract
Prion diseases are incurable neurodegenerative disorders. Our previous study demonstrated that polylysine was effective in prolonging the incubation period in a rodent model and in alleviating the scrapie prion protein (PrPSc) burden in the brain at the terminal stage of the disease. Here, we report that intraperitoneal administration of polylysine suppresses the accumulation of prions in the spleen during the early stages of the disease. This study supports the congruence of PrPSc inhibition by polylysine in both the spleen and brain.
Keywords
Prion; PrPSc; animal model; spleen; brain; polylysine;
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Times Cited By KSCI : 1  (Citation Analysis)
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