NQO1-Knockout Mice Are Highly Sensitive to Clostridium Difficile Toxin A-Induced Enteritis |
Nam, Seung Taek
(Department of Life Science, College of Natural Science, Daejin University)
Hwang, Jung Hwan (Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) Kim, Dae Hong (Department of Life Science, College of Natural Science, Daejin University) Lu, Li Fang (Department of Life Science, College of Natural Science, Daejin University) Hong, Ji (Department of Life Science, College of Natural Science, Daejin University) Zhang, Peng (Department of Life Science, College of Natural Science, Daejin University) Yoon, I Na (Department of Life Science, College of Natural Science, Daejin University) Hwang, Jae Sam (Department of Agricultural Biology, National Academy of Agricultural Science, RDA) Chung, Hyo Kyun (Department of Internal Medicine, Chungnam National University) Shong, Minho (Department of Internal Medicine, Chungnam National University) Lee, Chul-Ho (Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) Kim, Ho (Department of Life Science, College of Natural Science, Daejin University) |
1 | Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, et al. 2007. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ. Res. 100: 1512-1521. DOI |
2 | Alscher KT, Phang PT, McDonald TE, Walley KR. 2001. Enteral feeding decreases gut apoptosis, permeability, and lung inflammation during murine endotoxemia. Am. J. Physiol. Gastrointest. Liver Physiol. 281: G569-G576. DOI |
3 | Berger F, Ramirez-Hernandez MH, Ziegler M. 2004. The new life of a centenarian: signalling functions of NAD(P). Trends Biochem. Sci. 29: 111-118. DOI |
4 | Cheng X, Chapple SJ, Patel B , Puszyk W, Sugden D, Yin X, et al. 2013. Gestational diabetes mellitus impairs Nrf2-mediated adaptive antioxidant defenses and redox signaling in fetal endothelial cells in utero. Diabetes 62: 4088-4097. DOI |
5 | Guarente L, Picard F. 2005. Calorie restriction - the SIR2 connection. Cell 120: 473-482. DOI |
6 | Kelly CP, Pothoulakis C, LaMont JT. 1994. Clostridium difficile colitis. N. Engl. J. Med. 330: 257-262. DOI |
7 | Hwang JH, Kim DW, Jo EJ, Kim YK, Jo YS, Park JH, et al. 2009. Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice. Diabetes 58: 965-974. DOI |
8 | Iskander K, Li J, Han S, Zheng B, Jaiswal AK. 2006. NQO1 and NQO2 regulation of humoral immunity and autoimmunity. J. Biol. Chem. 281: 30917-30924. DOI |
9 | Jaiswal AK. 2000. Regulation of genes encoding NAD(P)H:quinone oxidoreductases. Free Radic. Biol. Med. 29: 254-262. DOI |
10 | Khanna S, Pardi DS. 2012. Clostridium difficile infection: new insights into management. Mayo Clin. Proc. 87: 1106-1117. DOI |
11 | Kim DH, Lee IH, Nam ST, Hong J, Zhang P, Lu LF, et al. 2015. Antimicrobial peptide, lumbricusin, ameliorates motor dysfunction and dopaminergic neurodegeneration in a mouse model of Parkinson's disease. J. Microbiol. Biotechnol. 25: 1640-1647. DOI |
12 | Kim H, Kokkotou E, Na X, Rhee SH, Moyer MP, Pothoulakis C, et al. 2005. Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. Gastroenterology 129: 1875-1888. DOI |
13 | Long DJ, Iskander K, Gaikwad A, Arin M, Roop DR, Knox R, et al. 2002. Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity. J. Biol. Chem. 277: 46131-46139. DOI |
14 | Kim H, Rhee SH, Kokkotou E, Na X, Savidge T, Moyer MP, et al. 2005. Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. J. Biol. Chem. 280: 21237-21245. DOI |
15 | Kim H, Rhee SH, Pothoulakis C, Lamont JT. 2007. Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand. Gastroenterology 133: 875-886. DOI |
16 | Pollak N, Dolle C, Ziegler M. 2007. The power to reduce: pyridine nucleotides - small molecules with a multitude of functions. Biochem. J. 402: 205-218. DOI |
17 | Nam HJ, Kang JK, Kim SK, Ahn KJ, Seok H, Park SJ, et al. 2010. Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation. J. Biol. Chem. 285: 32888-32896. DOI |
18 | Nam ST, Hwang JH, Kim DH, Park MJ, Lee IH, Nam HJ, et al. 2014. Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells. BMB Rep. 47: 494-499. DOI |
19 | Pothoulakis C, Castagliuolo I, LaMont JT, Jaffer A, O’Keane JC, Snider RM, et al. 1994. CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin. Proc. Natl. Acad. Sci. USA 91: 947-951. DOI |
20 | Pothoulakis C, Lamont JT. 2001. Microbes and microbial toxins: paradigms for microbial-mucosal interactions II. The integrated response of the intestine to Clostridium difficile toxins. Am. J. Physiol. Gastrointest. Liver Physiol. 280: G178-G183. DOI |
21 | Radjendirane V, Joseph P, Lee YH, Kimura S, Klein-Szanto AJ, Gonzalez FJ, Jaiswal AK. 1998. Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity. J. Biol. Chem. 273: 7382-7389. DOI |
22 | Rhee SH, Im E, Riegler M, Kokkotou E, O'Brien M, Pothoulakis C. 2005. Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc. Natl. Acad. Sci. USA 102: 13610-13615. DOI |
23 | Yeo SH, Noh JR, Kim YH, Gang GT, Kim SW, Kim KS, et al. Increased vulnerability to beta-cell destruction and diabetes in mice lacking NAD(P)H:quinone oxidoreductase 1. Toxicol. Lett. 219: 35-41. DOI |
24 | Rushworth S A, MacEwan D J, O’Connell MA. 2008. Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes. J. Immunol. 181: 6730-6737. DOI |
25 | Solomon K, Webb J, Ali N, Robins RA, Mahida YR. 2005. Monocytes are highly sensitive to Clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death. Infect. Immun. 73: 1625-1634. DOI |
26 | Winski SL, Koutalos Y, Bentley DL, Ross D. 2002. Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells. Cancer Res. 62: 1420-1424. |