The Protein Kinase A Pathway Regulates Zearalenone Production by Modulating Alternative ZEB2 Transcription |
Park, Ae Ran
(Department of Agricultural Biotechnology, Seoul National University)
Fu, Minmin (Department of Agricultural Biotechnology, Seoul National University) Shin, Ji Young (Department of Agricultural Biotechnology, Seoul National University) Son, Hokyoung (Department of Agricultural Biotechnology, Seoul National University) Lee, Yin-Won (Department of Agricultural Biotechnology, Seoul National University) |
1 | Banno S, Ochiai N, Noguchi R, Kimura M, Yamaguchi I, Kanzaki S-i, et al. 2005. A catalytic subunit of cyclic AMP-dependent protein kinase, PKAC-1, regulates asexual differentiation in Neurospora crassa. Genes Genet. Syst. 80: 25-34. DOI |
2 | Bowden RL, Leslie JF. 1999. Sexual recombination in Gibberella zeae. Phytopathology 89: 182-188. DOI |
3 | Casperson GF, Walker N, Bourne HR. 1985. Isolation of the gene encoding adenylate cyclase in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 82: 5060-5063. DOI |
4 | Choi W, Dean RA. 1997. The adenylate cyclase gene MAC1 of Magnaporthe grisea controls appressorium formation and other aspects of growth and development. Plant Cell 9: 1973-1983. DOI |
5 | Dürrenberger F, Wong K, Kronstad JW. 1998. Identification of a cAMP-dependent protein kinase catalytic subunit required for virulence and morphogenesis in Ustilago maydis. Proc. Natl. Acad. Sci. USA 95: 5684-5689. DOI |
6 | Desjardins AE. 2006. Fusarium Mycotoxins: Chemistry, Genetics, and Biology. APS Press, St. Paul, MN. |
7 | Ding B, Abe J-I, Wei H, Xu H, Che W, Aizawa T, et al. 2005. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Proc. Natl. Acad. Sci. USA 102: 14771-14776. DOI |
8 | Fillinger S, Chaveroche MK, Shimizu K, Keller N, d’Enfert C. 2002. cAMP and ras signalling independently control spore germination in the filamentous fungus Aspergillus nidulans. Mol. Microbiol. 44: 1001-1016. DOI |
9 | Green MR, Sambrook J. 2012. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. |
10 | Ha CH, Kim JY, Zhao J, Wang W, Jhun BS, Wong C, Jin ZG. 2010. PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy. Proc. Natl. Acad. Sci. USA 107: 15467-15472. DOI |
11 | Han Y-K, Kim M-D, Lee S-H, Yun S-H, Lee Y-W. 2007. A novel F-box protein involved in sexual development and pathogenesis in Gibberella zeae. Mol. Microbiol. 63: 768-779. DOI |
12 | Hou R, Jiang C, Zheng Q, Wang C, Xu J-R. 2015. The AreA transcription factor mediates the regulation of deoxynivalenol (DON) synthesis by ammonium and cyclic adenosine monophosphate (cAMP) signaling in Fusarium graminearum. Mol. Plant Pathol. 16: 987-999. DOI |
13 | Hu S, Zhou X, Gu X, Cao S, Wang C, Xu J-R. 2014. The cAMP-PKA pathway regulates growth, sexual and asexual differentiation, and pathogenesis in Fusarium graminearum. Mol. Plant Microbe Interact. 27: 557-566. DOI |
14 | Kim Y-T, Lee Y-R, Jin J, Han K-H, Kim H, Kim J-C, et al. 2005. Two different polyketide synthase genes are required for synthesis of zearalenone in Gibberella zeae. Mol. Microbiol. 58: 1102-1113. DOI |
15 | Lee J, Lee T, Lee Y-W, Yun S-H, Turgeon BG. 2003. Shifting fungal reproductive mode by manipulation of mating type genes: obligatory heterothallism of Gibberella zeae. Mol. Microbiol. 50: 145-152. DOI |
16 | Marasas WFO, Nelson PE, Toussoun TA. 1984. Toxigenic Fusarium Species. Identity and Mycotoxicology. The Pennsylvania State University Press, University Park, PA. |
17 | Lee S, Son H, Lee J, Min K, Choi GJ, Kim J-C, Lee Y-W. 2011. Functional analyses of two acetyl coenzyme A synthetases in the ascomycete Gibberella zeae. Eukaryot. Cell 10: 1043-1052. DOI |
18 | Lengeler KB, Davidson RC, D’Souza C, Harashima T, Shen W-C, Wang P, et al. 2000. Signal transduction cascades regulating fungal development and virulence. Microbiol. Mol. Biol. Rev. 64: 746-785. DOI |
19 | Leslie JF, Summerell BA. 2006. The Fusarium Laboratory Manual. Blackwell Publishing, Ames, IA. |
20 | McMullen M, Jones R, Gallenberg D. 1997. Scab of wheat and barley: a re-emerging disease of devastating impact. Plant Dis. 81: 1340-1348. DOI |
21 | Min K, Shin Y, Son H, Lee J, Kim J-C, Choi GJ, Lee Y-W. 2012. Functional analyses of the nitrogen regulatory gene areA in Gibberella zeae. FEMS Microbiol. Lett. 334: 66-73. DOI |
22 | Namiki F, Matsunaga M, Okuda M, Inoue I, Nishi K, Fujita Y, Tsuge T. 2001. Mutation of an arginine biosynthesis gene causes reduced pathogenicity in Fusarium oxysporum f. sp. melonis. Mol. Plant Microbe Interact. 14: 580-584. DOI |
23 | Neves SR, Ram PT, Iyengar R. 2002. G protein pathways. Science 296: 1636-1639. DOI |
24 | Park AR, Cho A-R, Seo J-A, Min K, Son H, Lee J, et al. 2012. Functional analyses of regulators of G protein signaling in Gibberella zeae. Fungal Genet. Biol. 49: 511-520. DOI |
25 | Park AR, Son H, Min K, Park J, Goo JH, Rhee S, et al. 2015. Autoregulation of ZEB2 expression for zearalenone production in Fusarium graminearum. Mol. Microbiol. 97: 942-956. DOI |
26 | Windels CE. 2000. Economic and social impacts of Fusarium head blight: changing farms and rural communities in the northern great plains. Phytopathology 90: 17-21. DOI |
27 | Roze LV, Beaudry RM, Keller NP, Linz JE. 2004. Regulation of aflatoxin synthesis by FadA/cAMP/protein kinase A signaling in Aspergillus parasiticus. Mycopathologia 158: 219-232. DOI |
28 | Shimizu K, Hicks JK, Huang T-P, Keller NP. 2003. Pka, Ras and RGS protein interactions regulate activity of AflR, a Zn (II) 2Cys6 transcription factor in Aspergillus nidulans. Genetics 165: 1095-1104. |
29 | Shimizu K, Keller NP. 2001. Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans. Genetics 157: 591-600. |
30 | Yu H-Y, Seo J-A, Kim J-E, Han K-H, Shim W-B, Yun S-H, Lee Y-W. 2008. Functional analyses of heterotrimeric G protein Gα and Gβ subunits in Gibberella zeae. Microbiology 154: 392-401. DOI |
31 | Yu J-H, Hamari Z, Han K-H, Seo J-A, Reyes-Domínguez Y, Scazzocchio C. 2004. Double-joint PCR: a PCR-based molecular tool for gene manipulations in filamentous fungi. Fungal Genet. Biol. 41: 973-981. DOI |
32 | Yu J-H, Keller N. 2005. Regulation of secondary metabolism in filamentous fungi. Annu. Rev. Phytopathol. 43: 437-458. DOI |
33 | Zinedine A, Soriano JM, Molto JC, Manes J. 2007. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin. Food Chem. Toxicol. 45: 1-18. DOI |