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http://dx.doi.org/10.4014/jmb.1511.11024

Protective Effect of 4-(3,4-Dihydroxyphenyl)-3-Buten-2-One from Phellinus linteus on Naproxen-Induced Gastric Antral Ulcers in Rats  

Kim, Jeong-Hwan (Blue-Bio Industry RIC, Dong-Eui University)
Kwon, Hyun Ju (Blue-Bio Industry RIC, Dong-Eui University)
Kim, Byung Woo (Blue-Bio Industry RIC, Dong-Eui University)
Publication Information
Journal of Microbiology and Biotechnology / v.26, no.5, 2016 , pp. 823-828 More about this Journal
Abstract
The present study investigated the protective effect of naturally purified 4-(3,4-dihydroxyphenyl)-3-buten-2-one (DHP) from Phellinus linteus against naproxen-induced gastric antral ulcers in rats. To verify the protective effect of DHP on naproxen-induced gastric antral ulcers, various doses (1, 5, and 10 μg/kg) of DHP were pretreated for 3 days, and then gastric damage was caused by 80 mg/kg naproxen applied for 3 days. DHP prevented naproxen-induced gastric antral ulcers in a dose-dependent manner. In particular, 10 μg/kg DHP showed the best protective effect against naproxen-induced gastric antral ulcers. Moreover, DHP significantly attenuated the naproxen-induced lipid peroxide level in gastric mucosa and increased the activities of radical scavenging enzymes, such as superoxide dismutase, catalase, and glutathione peroxidase, in a dose-dependent manner. A histological examination clearly demonstrated that the gastric antral ulcer induced by naproxen nearly disappeared after the pretreatment of DHP. These results suggest that DHP can inhibit naproxen-induced gastric antral ulcers through prevention of lipid peroxidation and activation of radical scavenging enzymes.
Keywords
Anti-ulcer drug; DHP; gastric antral ulcer; naproxen; Phellinus linteus;
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