[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4014/jmb.1505.05078

In Vitro Effects of Dietary Inulin on Human Fecal Microbiota and Butyrate Production

Jung, Tae-Hwan (Department of Animal Biotechnology and Resource, Sahmyook University)
Jeon, Woo-Min (Department of Animal Biotechnology and Resource, Sahmyook University)
Han, Kyoung-Sik (Department of Animal Biotechnology and Resource, Sahmyook University)

Publication Information

Journal of Microbiology and Biotechnology / v.25, no.9, 2015 , pp. 1555-1558 More about this Journal

Abstract

Administration of dietary fibers has various health benefits, mainly by increasing numbers of beneficial bacteria and enhancing production of short-chain fatty acids in the colon. There has been growing interest in the addition of dietary fiber to human diet, due to its prebiotic effects. This study aimed to evaluate the prebiotic activity of inulin using an in vitro batch fermentation system with human fecal microbiota. Fermentation of inulin resulted in a significantly greater ratio of Lactobacillus or Bifidobacteria to Enterobacteria strains as an index of healthy human intestine and elevated butyrate concentration, which are related to improvement of gut health.

Keywords

In vitro fermentation; human fecal microbiota; inulin; butyrate;

Citations & Related Records

Reference

1	Ooi LG, Liong, MT. 2010. Cholesterol-lowering effects of probiotics and prebiotics: a review of in vivo and in vitro findings. Int. J. Mol. Sci. 11: 2499-2522. DOI
2	Pieper R, Jha R, Rossnagel B, Van Kessel AG, Souffrant WB, Leterme P. 2008. Effect of barley and oat cultivars with different carbohydrate compositions on the intestinal bacterial communities in weaned piglets. FEMS Microbiol. Ecol. 66: 556-566. DOI
3	Rafter J, Bennett M, Caderni G, Clune Y, Hughes R, Karlsson PC, et al. 2007. Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am. J. Clin. Nutr. 85: 488-496. DOI
4	Roberfroid M. 2007. Prebiotics: the concept revisited. J. Nutr. 137: 830S-837S. DOI
5	Roediger WEW. 1980. Role of anaerobic-bacteria in the metabolic welfare of the colonic mucosa in man. Gut 21: 793-798. DOI
6	Seifert S, Watzl B. 2007. Inulin and oligofructose: a review of experimental data on immune modulation. J. Nutr. 137: S2563-S2567. DOI
7	Topping DL, Fukushima M, Bird AR. 2003. Resistant starch as a prebiotic and symbiotic: state of the art. Proc. Nutr. Soc. 62: 171-176. DOI
8	Verstegen MW, Williams BA. 2002. Alternatives to the use of antibiotics as growth promoters for monogastric animals. Anim. Biotechnol. 13: 113-127. DOI
9	Wang X, Gibson GR. 1993. Effects of the in vitro fermentation of oligofructose and inulin by bacteria growing in the human large-intestine. J. Appl. Bacteriol. 75: 373-380. DOI
10	Ewing WN, Cole DJA. 1996. The living gut: an introduction to microorganisms in nutrition. Livest. Prod. Sci. 45: 221-222.
11	Forestier C, De Chams C, Vatoux C, Joly B. 2001. Probiotic activities of Lactobacillus casei rhamnosus: in vitro adherence to intestinal cells and antimicrobial properties. Res. Microbiol. 152: 167-173. DOI
12	Fujiwara S, Hashiba H, Hirota T, Forstner JF. 1997. Proteinaceous factor(s) in culture supernatant fluids of Bifidobacterium which prevents the binding of enterotoxigenic Escherichia coli to gangliotetraosylceramide. Appl. Environ. Microbiol. 63: 506-512.
13	Guarner F. 2005. Inulin and oligofructose: impact on intestinal diseases and disorders. Br. J. Nutr. 93: S61-S65. DOI
14	Han KS, Balan P, Molist Gasa F, Boland M. 2011. Green kiwifruit modulates the colonic microbiota in growing pigs. Lett. Appl. Microbiol. 52: 379-385. DOI
15	Jenkins DJ, Kendall CW, Vuksan V. 1999. Inulin, oligofructose and intestinal function. J. Nutr. 129: 1431S-1433S. DOI
16	Kim Y, Kim SH, Whang KY, Kim YJ, Oh S. 2008. Inhibition of Escherichia coli O157:H7 attachment by interactions between lactic acid bacteria and intestinal epithelial cells. J. Microbiol. Biotechnol. 18: 1278-1285.
17	Niness KR. 1999. Inulin and oligofructose: what are they? J. Nutr. 129 (7 Suppl): 1402S-1406S. DOI
18	Ogawa M, Shimizu K, Nomoto K, Tanaka R, Hamabata T, Yamasaki S, et al. 2001. Inhibition of in vitro growth of Shiga toxin-producing Escherichia coli O157:H7 by probiotic Lactobacillus strains due to production of lactic acid. Int. J. Food Microbiol. 68: 135-140. DOI
19	Castillo M, Martin-Orue SM, Roca M, Manzanilla EG, Badiola I, Perez JF, Gasa J. 2006. The response of gastrointestinal microbiota to avilamycin, butyrate, and plant extracts in early-weaned pigs. J. Anim. Sci. 84: 2725-2734. DOI
20	Balan P, Han KS, Rutherfurd-Markwick K, Singh H, Moughan PJ. 2011. Ovine serum immunoglobulin has immunomodulatory effects in growing rats gavaged with Salmonella enteritidis. J. Nutr. 141: 950-956. DOI
21	Castillo M, Martin-Orue SM, Nofrarias M, Manzanilla EG, Gasa J. 2007. Changes in caecal microbiota and mucosal morphology of weaned pigs. Vet. Microbiol. 124: 239-247. DOI
22	De Preter V, Falony G, Windey K, Hamer HM, De Vuyst L, Verbeke K. 2010. The prebiotic, oligofructose-enriched inulin modulates the faecal metabolite profile: an in vitro analysis. Mol. Nutr. Food Res. 54: 1791-1801. DOI
23	Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, et al. 2013. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl. Acad. Sci. USA 110: 9066-9071. DOI

Reference

6	(2015) Phytothérapie : de la recherche à la pratique Microbiote et plantes (Partie 1) : introduction et application pratique aux maladies inflammatoires chroniques de l’intestin (MICI) / 14 (6) , 370
None	Joyce Gomes de Moraes. (2015) International journal of pediatrics Fecal Microbiota and Diet of Children with Chronic Constipation / 2016 (None) , 6787269
None	(2015) International journal of tryptophan research Meat Intake and the Dose of Vitamin B <SUB>3</SUB> – Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures? / 10 (None) , 1178646917704662
3	(2017) Microbiology spectrum Bifidobacteria and Their Health-Promoting Effects / 5 (3) , None
1	(2015) Beneficial microbes The composition and metabolism of faecal microbiota is specifically modulated by different dietary polysaccharides and mucin: an isothermal microcalorimetry study / 9 (1) , 21
2	(2015) The British journal of nutrition Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study / 119 (2) , 176
1	(2015) Trials A multicenter, randomized controlled comparison of three renutrition strategies for the management of moderate acute malnutrition among children aged from 6 to 24 months (the MALINEA project) / 19 (1) , 666
2	(2015) The FASEB journal : official publication of the Federation of American Societies for Experimental Biology Gut microbiome catabolites as novel modulators of muscle cell glucose metabolism / 33 (2) , 1887
6	(2015) Applied and environmental microbiology The Mode of Action of Chicory Roots on Skatole Production in Entire Male Pigs Is neither via Reducing the Population of Skatole-Producing Bacteria nor via Increased Butyrate Production in the Hindgut / 85 (6) , e02327-18
40	(2015) World journal of gastroenterology : WJG Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study / 25 (40) , 6129
7	(2020) FEMS microbiology ecology A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernouris / 96 (7) , fiaa105
2	(2015) Critical reviews in food science and nutrition Classical methods and perspectives for manipulating the human gut microbial ecosystem / 61 (2) , 234
2	(2015) Circulation research : a journal of the American Heart Association Butyrate-Rich Diets Improve Redox Status and Fibrin Lysis in Behçet’s Syndrome / 128 (2) , 278
3	(2021) Journal of animal physiology and animal nutrition Development of livestock feed additives using porcine blood cells / 105 (3) , 478
3	(2015) Revista de gastroenterología de México Fibra dietaria y microbiota, revisión narrativa de un grupo de expertos de la Asociación Mexicana de Gastroenterología / 86 (3) , 287
3	(2015) Revista de Gastroenterología de México Dietary fiber and the microbiota: A narrative review by a group of experts from the Asociación Mexicana de Gastroenterología / 86 (3) , 287
1	(2015) BMC cancer Oligosaccharides increase the genotoxic effect of colibactin produced by pks+ Escherichia coli strains / 21 (1) , 172
12	(2021) Biomolecules Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD / 11 (12) , 1903