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http://dx.doi.org/10.4014/jmb.1503.03005

Metabolomics-Based Chemotaxonomic Classification of Streptomyces spp. and Its Correlation with Antibacterial Activity  

Lee, Mee Youn (Department of Bioscience and Biotechnology, Konkuk University)
Kim, Hyang Yeon (Department of Bioscience and Biotechnology, Konkuk University)
Lee, Sarah (Department of Bioscience and Biotechnology, Konkuk University)
Kim, Jeong-Gu (Genomics Division, National Academy of Agricultural Science, Rural Development Administration)
Suh, Joo-Won (Center for Nutraceutical and Pharmaceutical Materials, Myongji University)
Lee, Choong Hwan (Department of Bioscience and Biotechnology, Konkuk University)
Publication Information
Journal of Microbiology and Biotechnology / v.25, no.8, 2015 , pp. 1265-1274 More about this Journal
Abstract
Secondary metabolite-based chemotaxonomic classification of Streptomyces (8 species, 14 strains) was performed using ultraperformance liquid chromatography-quadrupole-time-offlight-mass spectrometry with multivariate statistical analysis. Most strains were generally well separated by grouping under each species. In particular, S. rimosus was discriminated from the remaining sevens pecies (S. coelicolor, S. griseus, S. indigoferus, S. peucetius, S. rubrolavendulae, S. scabiei, and S. virginiae) in partial least squares discriminant analysis, and oxytetracycline and rimocidin were identified as S. rimosus-specific metabolites. S. rimosus also showed high antibacterial activity against Xanthomonas oryzae pv. oryzae, the pathogen responsible for rice bacterial blight. This study demonstrated that metabolite-based chemotaxonomic classification is an effective tool for distinguishing Streptomyces spp. and for determining their species-specific metabolites.
Keywords
Streptomyces; chemotaxonomy; antibacterial activity;
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