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http://dx.doi.org/10.4014/jmb.1410.10050

Inhibition of Yeast Growth by Broadly Cross-Reactive Antisera Elicited by Heterologous Mannan-Protein Conjugate  

Machova, Eva (Institute of Chemistry, Slovak Academy of Sciences)
Korcova, Jana (Institute of Chemistry, Slovak Academy of Sciences)
Cizova, Alzbeta (Institute of Chemistry, Slovak Academy of Sciences)
Bystricky, Slavomir (Institute of Chemistry, Slovak Academy of Sciences)
Publication Information
Journal of Microbiology and Biotechnology / v.25, no.7, 2015 , pp. 1177-1179 More about this Journal
Abstract
A new approach to obtain broadly cross-reactive antisera against important yeast pathogens by intensive hyperimmunization with polysaccharide-protein conjugates is described here. Surface mannan of Candida albicans and capsular galactoglucoxylomannan of Cryptococcus laurentii were isolated and chemically linked to human serum albumin. Antisera elicited by a 7-week vigorous immunization of rabbits with the conjugates showed effective cross-reactive growth inhibition of different representatives of Candida spp. as well as Cryptococcus spp. IgG antibodies are evidenced as the effective component of the antisera.
Keywords
Candida; Cryptococcus; mannan conjugate; cross-growth inhibition;
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