A Bacterial Metabolite, Compound K, Induces Programmed Necrosis in MCF-7 Cells via GSK3β |
Kwak, Chae Won
(Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University)
Son, Young Min (Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) Gu, Min Jeong (Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) Kim, Girak (Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) Lee, In Kyu (Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) Kye, Yoon Chul (Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) Kim, Han Wool (Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) Song, Ki-Duk (Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) Chu, Hyuk (Division of Zoonoses, Center for Immunology and Pathology, Korea National Institute of Health) Park, Byung-Chul (Institute of Green Bio Science and Technology, Seoul National University) Lee, Hak-Kyo (Department of Animal Biotechnology, Chonbuk National University) Yang, Deok-Chun (Korean Ginseng Center for Most Valuable Product & Ginseng Genetic Resource Bank, Kyung Hee University) Sprent, Jonathan (Garvan Institute of Medical Research) Yun, Cheol-Heui (Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University) |
1 | Hu C, Song G, Zhang B, Liu Z, Chen R, Zhang H, Hu T. 2011. Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway. J. Cell Mol. Med. 16: 96-106. DOI |
2 | Jacobs KM, Bhave SR, Ferraro DJ, Jaboin JJ, Hallahan DE, Thotala D. 2012. GSK-3beta: a bifunctional role in cell death pathways. Int. J. Cell Biol. 2012: 930710. DOI |
3 | Jiang X, Perez-Torres CJ, Thotala D, Engelbach JA, Yuan L, Cates J, et al. 2014. A GSK-3beta inhibitor protects against radiation necrosis in mouse brain. Int. J. Radiat. Oncol. Biol. Phys. 89: 714-721. DOI |
4 | Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, et al. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19: 5720-5728. DOI |
5 | Bae EA, Choo MK, Park EK, Park SY, Shin HY, Kim DH. 2002. Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity. Biol. Pharm. Bull. 25: 743-747. DOI |
6 | Beurel E, Jope RS. 2006. The paradoxical pro- and antiapoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog. Neurobiol. 79: 173-189. DOI |
7 | Choi KH, Min JY, Ganesan P, Bae IH, Kwak HS. 2015. Physicochemical and sensory properties of red ginseng extracts or red ginseng hydrolyzates-added Asiago cheese during ripening. Asian Australas J. Anim. Sci. 28: 120-126. DOI |
8 | Akao T, Kida H, Kanaoka M, Hattori M, Kobashi K. 1998. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J. Pharm. Pharmacol. 50: 1155-1160. DOI |
9 | Artus C, Boujrad H, Bouharrour A, Brunelle MN, Hoos S, Yuste VJ, et al. 2010. AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. EMBO J. 29: 1585-1599. DOI |
10 | Diehl JA, Cheng M, Roussel MF, Sherr CJ. 1998. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 12: 3499-3511. DOI |
11 | Edinger AL, Thompson CB. 2004. Death by design: apoptosis, necrosis and autophagy. Curr. Opin. Cell Biol. 16: 663-669. DOI |
12 | Eom JM, Seo MJ, Baek JY, Chu H, Han SH, Min TS, et al. 2010. Alpha-eleostearic acid induces autophagy-dependent cell death through targeting AKT/mTOR and ERK1/2 signal together with the generation of reactive oxygen species. Biochem. Biophys. Res. Commun. 391: 903-908. DOI |
13 | Wang SH, Shih YL, Kuo TC, Ko WC, Shih CM. 2009. Cadmium toxicity toward autophagy through ROS-activated GSK-3beta in mesangial cells. Toxicol. Sci. 108: 124-131. DOI |
14 | Zhang Z, Du GJ, Wang CZ, Wen XD, Calway T, Li Z, et al. 2013. Compound K, a ginsenoside metabolite, inhibits colon cancer growth via multiple pathways including p53-p21 interactions. Int. J. Mol. Sci. 14: 2980-2995. DOI |
15 | Soldani C, Scovassi AI. 2002. Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Apoptosis 7: 321-328. DOI |
16 | Son YM, Kwak CW, Lee YJ, Yang DC, Park BC, Lee WK, et al. 2010. Ginsenoside Re enhances survival of human CD4+ T cells through regulation of autophagy. Int. Immunopharmacol. 10: 626-631. DOI |
17 | Yeh CT, Yao CJ, Yan JL, Chuang SE, Lee LM, Chen CM, et al. 2011. Apoptotic cell death and inhibition of Wnt/betacatenin signaling pathway in human colon cancer cells by an active fraction (HS7) from Taiwanofungus camphoratus. Evid. Based Complement. Alternat. Med. 2011: 750230. |
18 | Yan Q, Zhou W, Shi XL, Zhou P, Ju DW, Feng MQ. 2010. Biotransformation pathways of ginsenoside Rb1 to compound K by beta-glucosidases in fungus Paecilomyces Bainier sp 229. Process Biochem. 45: 1550-1556. DOI |
19 | Yang H, Rivera Z, Jube S, Nasu M, Bertino P, Goparaju C, et al. 2010. Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation. Proc. Natl. Acad. Sci. USA 107: 12611-12616. DOI |
20 | Yang J, Fan W, Xiao H, Guan C, Cao C, Shao H, et al. 2010. Genome shuffling method of Bacillus subtilis. Sheng Wu Gong Cheng Xue Bao 26: 1385-1392. |
21 | Yost C, Torres M, Miller JR, Huang E, Kimelman D, Moon RT. 1996. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev. 10: 1443-1454. DOI |
22 | Li Y, Zhou T, Ma C, Song W, Zhang J, Yu Z. 2015. Ginsenoside metabolite compound K enhances the efficacy of cisplatin in lung cancer cells. J. Thorac. Dis. 7: 400-406. |
23 | Liu Q, Mier JW, Panka DJ. 2011. Differential modulatory effects of GSK-3beta and HDM2 on sorafenib-induced AIF nuclear translocation (programmed necrosis) in melanoma. Mol. Cancer 10: 115. DOI |
24 | Ming YL, Song G, Chen LH, Zheng ZZ, Chen ZY, Ouyang GL, Tong QX. 2007. Anti-proliferation and apoptosis induced by a novel intestinal metabolite of ginseng saponin in human hepatocellular carcinoma cells. Cell Biol. Int. 31: 1265-1273. DOI |
25 | Schlange T, Matsuda Y, Lienhard S, Huber A, Hynes NE. 2007. Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Breast Cancer Res. 9: R63. DOI |
26 | Moubarak RS, Yuste VJ, Artus C, Bouharrour A, Greer PA, Menissier-de Murcia J, Susin SA. 2007. Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol. Cell Biol. 27: 4844-4862. DOI |
27 | Nicotera P, Lipton SA. 1999. Excitotoxins in neuronal apoptosis and necrosis. J. Cereb. Blood Flow Metab. 19: 583-591. DOI |
28 | Park EJ, Zhao YZ, Kim J, Sohn DH. 2006. A ginsenoside metabolite, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, triggers apoptosis in activated rat hepatic stellate cells via caspase-3 activation. Planta Med. 72: 1250-1253. DOI |
29 | Shall S, de Murcia G. 2000. Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? Mutat. Res. 460: 1-15. DOI |
30 | Kang KA, Kim YW, Kim SU, Chae S, Koh YS, Kim HS, et al. 2005. G1 phase arrest of the cell cycle by a ginseng metabolite, compound K, in U937 human monocytic leukamia cells. Arch. Pharm. Res. 28: 685-690. DOI |
31 | Kang KA, Piao MJ, Kim KC, Zheng J, Yao CW, Cha JW, et al. 2013. Compound K, a metabolite of ginseng saponin, inhibits colorectal cancer cell growth and induces apoptosis through inhibition of histone deacetylase activity. Int. J. Oncol. 43: 1907-1914. DOI |
32 | Kim AD, Kang KA, Kim HS, Kim DH, Choi YH, Lee SJ, et al. 2013. A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells. Cell Death Dis. 4: e750. DOI |
33 | Lee YJ, Son YM, Gu MJ, Song KD, Park SM, Song HJ, et al. 2015. Ginsenoside fractions regulate the action of monocytes and their differentiation into dendritic cells. J. Ginseng Res. 39: 29-37. DOI |
34 | Kim AD, Kang KA, Zhang R, Lim CM, Kim HS, Kim DH, et al. 2010. Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMPactivated protein kinase. Environ. Toxicol. Pharmacol. 30: 134-140. DOI |
35 | Law CK, Kwok HH, Poon PY, Lau CC, Jiang ZH, Tai WC, et al. 2014. Ginsenoside compound K induces apoptosis in nasopharyngeal carcinoma cells via activation of apoptosisinducing factor. Chin. Med. 9: 11. DOI |
36 | Lee JY, Shin JW, Chun KS, Park KK, Chung WY, Bang YJ, et al. 2005. Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadioltype ginsenosides in mouse skin. Carcinogenesis 26: 359-367. DOI |
37 | Gregory MA, Qi Y, Hann SR. 2003. Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization. J. Biol. Chem. 278: 51606-51612. DOI |
38 | Grimes CA, Jope RS. 2001. The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog. Neurobiol. 65: 391-426. DOI |
39 | Haince JF, Rouleau M, Hendzel MJ, Masson JY, Poirier GG. 2005. Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy. Trends Mol. Med. 11: 456-463. DOI |
40 | Hao HP, Zheng X, Wang GJ. 2014. Insights into drug discovery from natural medicines using reverse pharmacokinetics. Trends Pharmacol. Sci. 35: 168-177. DOI |
41 | Hengartner MO. 2000. The biochemistry of apoptosis. Nature 407: 770-776. DOI |
![]() |