A Novel Synthetic Compound, YH-1118, Inhibited LPS-Induced Inflammatory Response by Suppressing IκB Kinase/NF-κB Pathway in Raw 264.7 Cells |
Yun, Chang Hyun
(Laboratory of Chemoprevention, Lee Gil Ya Cancer and Diabetes Institute, Gachon University)
Jang, Eun Jung (Laboratory of Chemoprevention, Lee Gil Ya Cancer and Diabetes Institute, Gachon University) Kwon, Soon Cheon (Laboratory of Chemoprevention, Lee Gil Ya Cancer and Diabetes Institute, Gachon University) Lee, Mee-Young (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology) Lee, Sangku (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology) Oh, Sei-Ryang (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology) Lee, Hyeong-Kyu (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology) Ahn, Kyung-Seop (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology) Lee, Ho-Jae (Laboratory of Chemoprevention, Lee Gil Ya Cancer and Diabetes Institute, Gachon University) |
1 | Xie QW, Kashiwabara Y, Nathan C. 1994. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269: 4705-4708. |
2 | Xie QW, Whisnant R, Nathan C. 1993. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. J. Exp. Med. 177: 1779-1784. DOI |
3 | Zamora R, Vodovotz Y, Billiar TR. 2000. Inducible nitric oxide synthase and inflammatory diseases. Mol. Med. 6: 347-373. |
4 | Zandi E, Chen Y, Karin M. 1998. Direct phosphorylation of IkappaB by IKKα and IKKβ: discrimination between free and NF-kappaB-bound substrate. Science 281: 1360-1363. DOI |
5 | Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. 1997. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91: 243-252. DOI |
6 | Zhang W, Liu HT. 2002. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. 12: 9-18. DOI |
7 | Takeda K, Akira S. 2004. TLR signaling pathways. Seminars Immunol. 16: 3-9. DOI |
8 | Wu JT, Kral JG. 2005. The NF-kappaB/IkappaB signaling system: a molecular target in breast cancer therapy. J. Surg. Res. 123: 158-169. DOI |
9 | Matsushima A, Kaisho T, Rennert PD, Nakano H, Kurosawa K, Uchida D, et al. 2001. Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I. J. Exp. Med. 193: 631-636. DOI |
10 | Michel T, Feron O. 1997. Nitric oxide synthases: which, where, how, and why? J. Clin. Invest. 100: 2146-2152. DOI |
11 | Miller SI, Ernst RK, Bader MW. 2005. LPS, TLR4 and infectious disease diversity. Nature Rev. Microbiol. 3: 36-46. DOI |
12 | Nakano H, Shindo M, Sakon S, Nishinaka S, Mihara M, Yagita H, Okumura K. 1998. Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. USA 95: 3537-3542. DOI |
13 | Netea MG, van der Meer JW, van Deuren M, Kullberg BJ. 2003. Proinflammatory cytokines and sepsis syndrome: not enough, or too much of a good thing? Trends Immunol. 24: 254-258. DOI |
14 | Perkins ND. 2000. The Rel/NF-kappa B family: friend and foe. Biochem. Sci. 25: 434-440. DOI |
15 | Raetz CR, Whitfield C. 2002. Lipopolysaccharide endotoxins. Annu. Rev. Biochem. 71: 635-700. DOI |
16 | Shin HM, Kim MH, Kim BH, Jung SH, Kim YS, Park HJ, et al. 2004. Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation. FEBS Lett. 571: 50-54. DOI |
17 | Klemm S, Ruland J. 2006. Inflammatory signal transduction from the Fc epsilon RI to NF-kappa B. Immunobiology 211: 15-820. DOI |
18 | Stancovski I, Baltimore D. 1997. NF-kappaB activation: the I kappaB kinase revealed? Cell 91: 299-302. DOI |
19 | Kanterman J, Sade-Feldman M, Baniyash M. 2012. New insights into chronic inflammation-induced immunosuppression. Seminars Cancer Biol. 22: 307-318. DOI |
20 | Karin M. 1999. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. J. Biol. Chem. 274: 27339-27342. DOI |
21 | Lawrence T. 2009. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harbor Perspect. Biol. 1: a001651. DOI |
22 | Lee FS, Peters RT, Dang LC, Maniatis T. 1998. MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta. Proc. Natl. Acad. Sci. USA 95: 9319-9324. DOI |
23 | Liu SF, Malik AB. 2006. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L622-L645. DOI |
24 | Lowenstein CJ, Alley EW, Raval P, Snowman AM, Snyder SH, Russell SW, Murphy WJ. 1993. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc. Natl. Acad. Sci. USA 90: 9730-9734. DOI |
25 | MacMicking J, Xie QW, Nathan C. 1997. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15: 323-350. DOI |
26 | Marks-Konczalik J, Chu SC, Moss J. 1998. Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites. J. Biol. Chem. 273: 22201-22208. DOI |
27 | Carter AB, Knudtson KL, Monick MM, Hunninghake GW. 1999. The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP). J. Biol. Chem. 274: 30858-30863. DOI |
28 | Bertolini A, Ottani A, Sandrini M. 2001. Dual acting antiinflammatory drugs: a reappraisal. Pharmacol. Res. 44: 437-450. DOI |
29 | Broad A, Jones DE, Kirby JA. 2006. Toll-like receptor (TLR) response tolerance: a key physiological “damage limitation” effect and an important potential opportunity for therapy. Curr. Med. Chem. 13: 2487-2502. DOI |
30 | Brockman JA, Scherer DC, McKinsey TA, Hall SM, Qi X, Lee WY, Ballard DW. 1995. Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation. Mol. Cell. Biol. 15: 2809-2818. DOI |
31 | Chan ED, Riches DW. 2001. IFN-gamma + LPS induction of iNOS is modulated b y ERK, JNK/SAPK, and p 38(mapk) in a mouse macrophage cell line. Am. J. Physiol. Cell Physiol. 280: C441-C450. DOI |
32 | Chen CC, Wang JK. 1999. p38 but not p44/42 mitogenactivated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages. Mol. Pharmacol. 55: 481-488. |
33 | Geng Y, Zhang B, Lotz M. 1993. Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes. J. Immunol. 151: 6692-6700. |
34 | Ghosh S, Karin M. 2002. Missing pieces in the NF-kappaB puzzle. Cell 109(Suppl): S81-S96. DOI |
35 | Guha M, Mackman N. 2001. LPS induction of gene expression in human monocytes. Cell. Signal. 13: 85-94. DOI |