Browse > Article
http://dx.doi.org/10.4014/jmb.1409.09078

Inefficient Transmissibility of NS-Truncated H3N8 Equine Influenza Virus in Dogs  

Na, Woonsung (Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology)
Song, Manki (Molecular Vaccinology Section, Laboratory Science Division, International Vaccine Institute)
Yeom, Minjoo (Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology)
Park, Nanuri (Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology)
Kang, Bokyu (Research Unit, Green Cross Veterinary Products)
Moon, Hyoungjoon (Research Unit, Green Cross Veterinary Products)
Jeong, Dae-Gwin (University of Science and Technology)
Kim, Jeong-Ki (College of Pharmacy, Korea University)
Song, Daesub (Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology)
Publication Information
Journal of Microbiology and Biotechnology / v.25, no.3, 2015 , pp. 317-320 More about this Journal
Abstract
H3N8 equine influenza virus (EIV) causes respiratory diseases in the horse population, and it has been demonstrated that EIV can transmit into dogs owing to its availability on receptors of canine respiratory epithelial cells. Recently, we isolated H3N8 EIV from an EIV-vaccinated horse that showed symptoms of respiratory disease, and which has a partially truncated nonstructural gene (NS). However, it is not clear that the NS-truncated EIV has an ability to cross the host species barrier from horses to dogs as well. Here, we experimentally infected the NS-truncated H3N8 EIV into dogs, and monitored their clinical signs and viral load in respiratory organs to determine the virus's transmissibility.
Keywords
NS truncation; transmission; H3N8 EIV;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Quinlivan M, Zamarin D, Garcia-Sastre A, Cullinane A, Chambers T, Palese P. 2005. Attenuation of equine influenza viruses through truncations of the NS1 protein. J. Virol. 79: 8431-8439.   DOI   ScienceOn
2 Song D, Moon HJ, An DJ, Jeoung HY, Kim H, Yeom MJ, et al. 2012. A novel reassortant canine H3N1 influenza virus between pandemic H1N1 and canine H3N2 influenza viruses in Korea. J. Gen. Virol. 93: 551-554.   DOI   ScienceOn
3 Sovinova O, Tumova B, Pouska F, Nemec J. 1958. Isolation of a virus causing respiratory disease in horses. Acta Virol. 2: 52-61.
4 Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y. 1992. Evolution and ecology of influenza A viruses. Microbiol. Rev. 56: 152-179.
5 Waddell GH, Teigland MB, Sigel MM. 1963. A new influenza virus associated with equine respiratory disease. J. Am. Vet. Med. Assoc. 143: 587-590.
6 Watson J, Halpin K, Selleck P, Axell A, Bruce K, Hansson E, et al. 2011. Isolation and characterisation of an H3N8 equine influenza virus in Australia, 2007. Aust. Vet. J. 89(Suppl 1): 35-37.   DOI   ScienceOn
7 Webster RG. 1993. Are equine 1 influenza viruses still present in horses? Equine Vet. J. 25: 537-538.   DOI
8 Webster RG, Laver WG, Kilbourne ED. 1968. Reactions of antibodies with surface antigens of influenza virus. J. Gen. Virol. 3: 315-326.   DOI   ScienceOn
9 Yamanaka T, Nemoto M, Tsujimura K, Kondo T, Matsumura T. 2009. Interspecies transmission of equine influenza virus (H3N8) to dogs by close contact with experimentally infected horses. Vet. Microbiol. 139: 351-355.   DOI   ScienceOn
10 Crawford PC, Dubovi EJ, Castleman WL, Stephenson I, Gibbs EP, Chen L, et al. 2005. Transmission of equine influenza virus to dogs. Science 310: 482-485.   DOI   ScienceOn
11 Daly JM, Blunden AS, Macrae S, Miller J, Bowman SJ, Kolodziejek J, et al. 2008. Transmission of equine influenza virus to English foxhounds. Emerg. Infect. Dis. 14: 461-464.   DOI
12 Garcia-Sastre A, Egorov A, Matassov D, Brandt S, Levy DE, Durbin JE, et al. 1998. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 252: 324-330.   DOI   ScienceOn
13 Higgins DG, Bleasby AJ, Fuchs R. 1992. CLUSTAL V: improved software for multiple sequence alignment. Comput. Appl. Biosci. 8: 189-191.
14 Kirkland PD, Finlaison DS, Crispe E, Hurt AC. 2010. Influenza virus transmission from horses to dogs, Australia. Emerg. Infect. Dis. 16: 699-702.   DOI
15 Na W, Kang B, Kim HI, Hong M, Park SJ, Jeoung HY, et al. 2014. Isolation and genetic characterization of naturally NStruncated H3N8 equine influenza virus in South Korea. Epidemiol. Infect. 142: 759-766.   DOI   ScienceOn
16 Payungporn S, Crawford PC, Kouo TS, Chen LM, Pompey J, Castleman WL, et al. 2008. Influenza A virus (H3N8) in dogs with respiratory disease, Florida. Emerg. Infect. Dis. 14: 902-908.   DOI
17 Morens DM, Taubenberger JK. 2010. An avian outbreak associated with panzootic equine influenza in 1872: an early example of highly pathogenic avian influenza? Influenza Other Respir. Viruses 4: 373-377.   DOI   ScienceOn