Improved Production of Medium-Chain-Length Polyhydroxyalkanoates in Glucose-Based Fed-Batch Cultivations of Metabolically Engineered Pseudomonas putida Strains |
Poblete-Castro, Ignacio
(Microbial Drugs Group, Helmholtz Centre for Infection Research)
Rodriguez, Andre Luis (Institute of Biochemical Engineering, Technische Universitat Braunschweig) Lam, Carolyn Ming Chi (Systems and Synthetic Biology, Wageningen University) Kessler, Wolfgang (Microbial Drugs Group, Helmholtz Centre for Infection Research) |
1 | Poblete-Castro I, Escapa I, Jager C, Puchalka J, Lam CMC, Schomburg D, et al. 2012. The metabolic response of P. putida KT2442 producing high levels of polyhydroxyalkanoate under single- and multiple-nutrient-limited growth: highlights from a multi-level omics approach. Microb. Cell Factor. 11:34. DOI ScienceOn |
2 | Puchalka J, Oberhardt MA, Godinho M, Bielecka A, Regenhardt D, Timmis KN, et al. 2008. Genome-scale reconstruction and analysis of the Pseudomonas putida KT2440 metabolic network facilitates applications in biotechnology. PLoS Comput. Biol. 4: e1000210. DOI ScienceOn |
3 | Rai R, Keshavarz T, Roether JA, Boccaccini AR, Roy I. 2011. Medium chain length polyhydroxyalkanoates, promising new biomedical materials for the future. Mater. Sci. Eng. R Reports 72: 29-47. DOI ScienceOn |
4 | Simon-Colin C, Raguenes G, Crassous P, Moppert X, Guezennec J. 2008. A novel mcl-PHA produced on coprah oil by Pseudomonas guezennei biovar. tikehau, isolated from a kopara mat of French Polynesia. Int. J. Biol. Macromolec. 43: 176-181. DOI ScienceOn |
5 | Solaiman DY, Ashby R, Hotchkiss Jr A, Foglia T. 2006. Biosynthesis of medium-chain-length poly(hydroxyalkanoates) from soy molasses. Biotechnol. Lett. 28: 157-162. DOI ScienceOn |
6 | Sun Z, Ramsay J, Guay M, Ramsay B. 2006. Automated feeding strategies for high-cell-density fed-batch cultivation of Pseudomonas putida KT2440. Appl. Microbiol. Biotechnol. 71: 423-431. DOI |
7 | Lee H-J, Choi MH, Kim T-U, Yoon SC. 2001. Accumulation of polyhydroxyalkanoic acid containing large amounts of unsaturated monomers in Pseudomonas fluorescens BM07 utilizing saccharides and its inhibition by 2-bromooctanoic acid. Appl. Environ. Microbiol. 67: 4963-4974. DOI ScienceOn |
8 | Lee SY, Wong HH , Choi J I, L ee SH , Lee SC, H an CS. 2000. Production of medium-chain-length polyhydroxyalkanoates by high-cell-density cultivation of Pseudomonas putida under phosphorus limitation. Biotechnol. Bioeng. 68: 466-470. DOI ScienceOn |
9 | Liu Q, Luo G, Zhou XR, Chen GQ. 2011. Biosynthesis of poly(3-hydroxydecanoate) and 3-hydroxydodecanoate dominating polyhydroxyalkanoates by -oxidation pathway inhibited Pseudomonas putida. Metab. Eng. 13: 11-17. DOI ScienceOn |
10 | Mozejko J, Ciesielski S. 2013. Saponified waste palm oil as an attractive renewable resource for mcl-polyhydroxyalkanoate synthesis. J. Biosci. Bioeng. 116: 485-492. DOI ScienceOn |
11 | Muhr A, Rechberger EM, Salerno A, Reiterer A, Malli K, Strohmeier K, et al. 2013. Novel description of mcl-PHA biosynthesis by Pseudomonas chlororaphis from animalderived waste. J. Biotechnol. 165: 45-51. DOI ScienceOn |
12 | Poblete-Castro I, Binger D, Rodrigues A, Becker J, Martins dos Santos VAP, Wittmann C. 2013. In-silico-driven metabolic engineering of Pseudomonas putida for enhanced production of poly-hydroxyalkanoates. Metab. Eng. 15: 113-123. DOI ScienceOn |
13 | Muller C, Petruschka L, Cuypers H, Burchhardt G, and Herrmann H. 1996. Carbon catabolite repression of phenol degradation in Pseudomonas putida is mediated by the inhibition of the activator protein PhlR. J. Bacteriol. 178: 2030-2036. DOI |
14 | Ouyang SP, Luo RC, Chen SS, Liu Q, Chung A, Wu Q, Chen GQ. 2007. Production of polyhydroxyalkanoates with high 3-hydroxydodecanoate monomer content by fadB and fadA knockout mutant of Pseudomonas putida KT2442. Biomacromolecules 8: 2504-2511. DOI ScienceOn |
15 | Poblete-Castro I, Becker J, Dohnt K, dos Santos V, Wittmann C. 2012. Industrial biotechnology of Pseudomonas putida and related species. Appl. Microbiol. Biotechnol. 93: 2279-2290. DOI ScienceOn |
16 | Chen G-Q. 2009. A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry. Chem. Soc. Rev. 38: 2434- 2446. DOI ScienceOn |
17 | del Castillo T, Ramos JL, RodrA-guez-Herva JJ, Fuhrer T, Sauer U, Duque E. 2007. Convergent peripheral pathways catalyze initial glucose catabolism in Pseudomonas putida: genomic and flux analysis. J. Bacteriol. 189: 5142-5152. DOI ScienceOn |
18 | Follonier S, Panke S, Zinn M. 2011. A reduction in growth rate of Pseudomonas putida KT2442 counteracts productivity advances in medium-chain-length polyhydroxyalkanoate production from gluconate. Microb. Cell Factor. 10: 25. DOI ScienceOn |
19 | Frazzetto G. 2003. White biotechnology. EMBO Rep. 4: 835-837. DOI ScienceOn |
20 | Fujita Y, Matsuoka H, Hirooka K. 2007. Regulation of fatty acid metabolism in bacteria. Mol. Microbiol. 66: 829-839. DOI ScienceOn |
21 | Hartmann R, Hany R, Geiger T, Egli T, Witholt B, Zinn M. 2004. Tailored biosynthesis of olefinic medium-chain-length poly[(r)-3-hydroxyalkanoates] in Pseudomonas putida GPo1 with improved thermal properties. Macromolecules 37: 6780- 6785. DOI |
22 | Koller M, Atlic A, Dias M, Reiterer A, Braunegg G. 2010. Microbial PHA production from waste raw materials, p. 85-119 Plastics from Bacteria, Springer Berlin Heidelberg. |
23 | Huijberts GN, Eggink G, de Waard P, Huisman GW, Witholt B. 1992. Pseudomonas putida KT2442 cultivated on glucose accumulates poly(3-hydroxyalkanoates) consisting of saturated and unsaturated monomers. Appl. Environ. Microbiol. 58: 536-544. |
24 | Kim GJ, Lee IY, Yoon SC, Shin YC, Park YH. 1997. Enhanced yield and a high production of medium-chainlength poly(3-hydroxyalkanoates) in a two-step fed-batch cultivation of Pseudomonas putida by combined use of glucose and octanoate. Enzyme Microb. Technol. 20: 500-505. DOI ScienceOn |
25 | Klinke S, Dauner M, Scott G, Kessler B, Witholt B. 2000. Inactivation of isocitrate lyase leads to increased production of medium-chain-length poly(3-hydroxyalkanoates) in Pseudomonas putida. Appl. Environ. Microbiol. 66: 909-913. DOI |
26 | Sun Z, Ramsay JA, Guay M, Ramsay B. 2007. Increasing the yield of mcl-PHA from nonanoic acid by co-feeding glucose during the PHA accumulation stage in two-stage fed-batch fermentations of Pseudomonas putida KT2440. J. Biotechnol. 132: 280-282. DOI ScienceOn |
27 | Sun Z, Ramsay JA, Guay M, Ramsay BA. 2007. Carbonlimited fed-batch production of medium-chain-length polyhydroxyalkanoates from nonanoic acid by Pseudomonas putida KT2440. Appl. Microbiol. Biotechnol. 74: 69-77. DOI ScienceOn |
28 | Sun Z, Ramsay JA, Guay M, Ramsay BA. 2007. Fermentation process development for the production of medium-chainlength poly-3-hydroxyalkanoates. Appl. Microbiol. Biotechnol. 75: 475-485. DOI |
29 | van Duuren JBJH. 2011. Optimization of Pseudomonas putida KT2440 as Host for the Production of Cis, Cis-muconate from Benzoate. Wageningen University. |
30 | Wang Q, Tappel RC, Zhu C, Nomura CT. 2012. Development of a new strategy for production of medium-chain-length polyhydroxyalkanoates by recombinant Escherichia coli via inexpensive non-fatty acid feedstocks. Appl. Environ. Microbiol. 78: 519-527. DOI |
31 | Sun Z, Ramsay J, Guay M, Ramsay B. 2009. Enhanced yield of medium-chain-length polyhydroxyalkanoates from nonanoic acid by co-feeding glucose in carbon-limited, fed-batch culture. J. Biotechnol. 143: 262-267. DOI ScienceOn |
32 | Witholt B, Kessler B. 1999. Perspectives of medium chain length poly(hydroxyalkanoates), a versatile set of bacterial bioplastics. Curr. Opin. Biotechnol. 10: 279-285. DOI ScienceOn |
33 | Diniz S, Taciro M, Cabrera Gomez JGr, da Cruz Pradella JG. 2004. High-cell-density cultivation of Pseudomonas putida IPT 046 and medium-chain-length polyhydroxyalkanoate production from sugarcane carbohydrates. Appl. Biochem. Biotechnol. 119: 51-70. DOI ScienceOn |
34 | Escapa I, Morales V, Martino V, Pollet E, Averous L, Garcia J, Prieto M. 2011. Disruption of B-oxidation pathway in Pseudomonas putida KT2442 to produce new functionalized PHAs with thioester groups. Appl. Microbiol. Biotechnol. 89: 1583-1598. DOI |
35 | Smyth PF, Clarke PH. 1975. Catabolite repression of Pseudomonas aeruginosa amidase: the effect of carbon source on amidase synthesis. J. Gen. Microbiol. 90: 81-90. DOI |
36 | Wang B, Sharma-Shivappa R, Olson J, Khan S. 2012. Upstream process optimization of polyhydroxybutyrate (PHB) by Alcaligenes latus using two-stage batch and fed-batch fermentation strategies. Bioprocess Biosyst. Eng. 35: 1591- 1602. DOI ScienceOn |