[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4014/jmb.1406.06062

Different Immune Regulatory Potential of Lactobacillus plantarum and Lactobacillus sakei Isolated from Kimchi

Hong, Yi-Fan (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)
Kim, Hangeun (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)
Kim, Hye Rim (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)
Gim, Min Geun (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)
Chung, Dae Kyun (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)

Publication Information

Journal of Microbiology and Biotechnology / v.24, no.12, 2014 , pp. 1629-1635 More about this Journal

Abstract

It is known that lactic acid bacteria (LAB) have many beneficial health effects, including anti-oxidative activity and immune regulation. In this study, the immune regulatory effects of Lactobacillus sakei and Lactobacillus plantarum, which are found in different types of kimchi, were evaluated. L. sakei and its lipoteichoic acid (LTA) have greater immune stimulating potential in IL-12, IFN- ${\gamma}$ , and TNF- ${\alpha}$ production as compared with L. plantarum in an in vitro condition. On the other hand, L. plantarum is assumed to repress the Th1 immune response in murine experiments. After being injected with LPS, L. plantarum-fed mice maintained a healthier state, and the level of TNF- ${\alpha}$ in their blood was lower than in other bacterial strainfed mice and in the LPS-only control mice. Additionally, IL-12 production was significantly decreased and the production of IL-4 was greatly increased in the splenocytes from L. plantarum-fed mice. Further experiments revealed that the pre-injection of purified LTA from L. plantarum (pLTA), L. sakei (sLTA), and S. aureus (aLTA) decreased TNF- ${\alpha}$ and IL-4 production in LPS-injected mice. Mouse IL-12, however, was significantly increased by aLTA pre-injection. In conclusion, the L. sakei and L. plantarum strains have immune regulation effects, but the effects differ in cytokine production and the regulatory effects of the Th1/Th2 immune response.

Keywords

Lactobacillus plantarum; Lactobacillus sakei; kimchi; cytokine; lipoteichoic acid; immune regulation;

Citations & Related Records

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