Effect of Gene Amplifications in Porphyrin Pathway on Heme Biosynthesis in a Recombinant Escherichia coli |
Lee, Min Ju
(Department of Biotechnology, The Catholic University of Korea)
Kim, Hye-Jung (Department of Biotechnology, The Catholic University of Korea) Lee, Joo-Young (Department of Biotechnology, The Catholic University of Korea) Kwon, An Sung (iNtRON Biotechnology Inc.) Jun, Soo Youn (iNtRON Biotechnology Inc.) Kang, Sang Hyeon (iNtRON Biotechnology Inc.) Kim, Pil (Department of Biotechnology, The Catholic University of Korea) |
1 | Kwon, S. J., A. L. de Boer, R. Petri, and C. Schmidt-Dannert. 2003. High-level production of porphyrins in metabolically engineered Escherichia coli: Systematic extension of a pathway assembled from overexpressed genes involved in heme biosynthesis. Appl. Environ. Microbiol. 69: 4875-4883. DOI ScienceOn |
2 | Battersby, A. R. 2000. Tetrapyrroles: The pigments of life. Nat. Prod. Rep. 17: 507-526. DOI |
3 | Kim, H. J., Y. D. Kwon, S. Y. Lee, and P. Kim. 2012. An engineered Escherichia coli having a high intracellular level of ATP and enhanced recombinant protein production. Appl. Microbiol. Biotechnol. 94: 1079-1086. DOI ScienceOn |
4 | Kwon, O. H., S. Kim, D. H. Hahm, S. Y. Lee, and P. Kim. 2009. Potential application of the recombinant Escherichia colisynthesized heme as a bioavailable iron source. J. Microbiol. Biotechnol. 19: 604-609. |
5 | Rock, C. O., R. B. Calder, M. A. Karim, and S. Jackowski. 2000. Pantothenate kinase regulation of the intracellular concentration of coenzyme A. J. Biol. Chem. 275: 1377-1383. DOI ScienceOn |
6 | Kwon, S. J., R. Petri, A. L. DeBoer, and C. Schmidt-Dannert. 2004. A high-throughput screen for porphyrin metal chelatases: Application to the directed evolution of ferrochelatases for metalloporphyrin biosynthesis. Chembiochem 5: 1069-1074. DOI ScienceOn |
7 | Lee, M. J., S. J. Chun, H. J. Kim, A. S. Kwon, S. Y. Jun, S. H. Kang, and P. Kim. 2012. Porphyrin derivatives from a recombinant Escherichia coli grown on chemically defined medium. J. Microbiol. Biotechnol. 22: 1653-1658. DOI ScienceOn |
8 | Monsen, E. R. and J. L. Balintfy. 1982. Calculating dietary iron bioavailability: Refinement and computerization. J. Am. Diet. Assoc. 80: 307-311. |
9 | Rock, C. O., H. W. Park, and S. Jackowski. 2003. Role of feedback regulation of pantothenate kinase (CoaA) in control of coenzyme A levels in Escherichia coli. J. Bacteriol. 185: 3410-3415. DOI |
10 | Shin, J. A., Y. D. Kwon, O. H. Kwon, H. S. Lee, and P. Kim. 2007. 5-Aminolevulinic acid biosynthesis in Escherichia coli coexpressing NADP-dependent malic enzyme and 5-aminolevulinate synthase. J. Microbiol. Biotechnol. 17: 1579-1584. |
11 | Turhan, S., T. B. Altunkaynak, and F. Yazici. 2004. A note on the total and heme iron contents of ready-to-eat doner kebabs. Meat Sci. 67: 191-194. DOI ScienceOn |
12 | Vallari, D. S. and S. Jackowski. 1988. Biosynthesis and degradation both contribute to the regulation of coenzyme A content in Escherichia coli. J. Bacteriol. 170: 3961-3966. |
![]() |