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http://dx.doi.org/10.4014/jmb.1212.12050

Epidemiology of Respiratory Viral Infection using Multiplex RT-PCR in Cheonan, Korea (2006-2010)  

Kim, Jae Kyung (Department of Laboratory Medicine, Dankook University Hospital)
Jeon, Jae-Sik (Department of Laboratory Medicine, Dankook University College of Medicine)
Kim, Jong Wan (Department of Laboratory Medicine, Dankook University College of Medicine)
Rheem, Insoo (Department of Laboratory Medicine, Dankook University College of Medicine)
Publication Information
Journal of Microbiology and Biotechnology / v.23, no.2, 2013 , pp. 267-273 More about this Journal
Abstract
Multiplex RT-PCR was used to detect respiratory viruses in 5,318 clinical samples referred to the laboratory of a tertiary teaching hospital from December 2006 to November 2010. The acquired data were analyzed with respect to types, ratio, and co-infection trends of infected respiratory viruses. Trends in respiratory viral infection according to sex, age, and period of infection were also analyzed. Of the 5,318 submitted clinical samples, 3,350 (63.0%) specimens were positive for at least one respiratory virus. The infection rates were 15.8% for human rhinovirus, 14.4% for human respiratory syncytial virus A, 9.7% for human respiratory syncytial virus B, 10.1% for human adenovirus, 5.4% for influenza A virus, 1.7% for influenza B virus, 4.7% for human metapneumovirus, 2.3% for human coronavirus OC43, 1.9% for human coronavirus 229E/NL63, 3.7% for human parainfluenza virus (HPIV)-1, 1.1% for HPIV-2, and 5.3% for HPIV-3. The co-infection analysis showed 17.1% of double infections, 1.8% of triple infections. The median age of virus-positive patients was 1.3 years old, and the 91.5% of virus-positive patients were under 10 years old. Human respiratory syncytial virus was the most common virus in children < 5 years of age and the influenza A virus was most prevalent virus in children over 5 years of age. These results help in elucidating the tendency of respiratory viral infections.
Keywords
Respiratory virus; epidemiology; multiplex RTPCR;
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