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http://dx.doi.org/10.4014/jmb.1211.11032

Effect of Cordycepin on the Expression of the Inflammatory Cytokines TNF-alpha, IL-6, and IL-17A in C57BL/6 Mice  

Seo, Min Jeong (Department of Biotechnology, Dong-A University)
Kim, Min Jeong (Department of Biotechnology, Dong-A University)
Lee, Hye Hyeon (Department of Biotechnology, Dong-A University)
Park, Jeong Uck (Medi-Farm Industrialization Research Center, Dong-A University)
Kang, Byoung Won (Medi-Farm Industrialization Research Center, Dong-A University)
Kim, Gi-Young (Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University)
Rhu, En Ju (Department of Cosmetology, Hanseo University)
Kim, Jung-In (School of Food & Life Sciences, Inje University)
Kim, Kwang Hyuk (Department of Microbiology, Kosin University College of Medicine)
Jeong, Yong Kee (Department of Biotechnology, Dong-A University)
Publication Information
Journal of Microbiology and Biotechnology / v.23, no.2, 2013 , pp. 156-160 More about this Journal
Abstract
Culture supernatants of splenocytes from C57BL/6 mice were exposed to 0.3, 1.0, and 3.0 ${\mu}g/ml$ cordycepin plus 3.0 ${\mu}g/ml$ lipopolysaccharide (LPS) to investigate the effects of cordycepin (3'-deoxyadenosine) on the production of inflammatory cytokines. Coadministration of 3.0 ${\mu}g/ml$ cordycepin with LPS in cultured murine spleen cells significantly diminished expression of the inflammatory cytokines tumor necrosis factor-${\alpha}$ and interleukin-6 (IL-6) in a time-dependent manner. Expression of the inflammatory cytokine IL-17A was substantially downregulated in a timeand concentration-dependent manner at all cordycepin concentrations. These findings suggest that cordycepin downregulates the immediate hypersensitivity reaction stimulated by LPS.
Keywords
Cordycepin; IL-17A; IL-6; splenocytes; TNF-${\alpha}$;
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