The Effect of Spent Medium Recycle on Cell Proliferation, Metabolism and Baculovirus Production by the Lepidopteran Se301 Cell Line Infected at Very Low MOI |
Beas-Catena, Alba
(Department of Chemical Engineering, University of Almeria)
Sanchez-Miron, Asterio (Department of Chemical Engineering, University of Almeria) Garcia-Camacho, Francisco (Department of Chemical Engineering, University of Almeria) Contreras-Gomez, Antonio (Department of Chemical Engineering, University of Almeria) Molina-Grima, Emilio (Department of Chemical Engineering, University of Almeria) |
1 | Reuveny S, Kim YC, Kemp CW, Shiloach J. 1993. Production of recombinant proteins in high-density insect cell cultures. Biotechnol. Bioeng. 42: 235-239. DOI ScienceOn |
2 | Riese U, Lutkemeyer D, Heidemann R, Buntemeyer H, Lehmann J. 1994. Reuse of spent cell culture medium in pilot-scale and rapid preparative purification with membrane chromatography. J. Biotechnol. 34: 247-257. DOI ScienceOn |
3 | Rodas VM, Marques FH, Honda MT, Soares DM, Jorge SAC, Antoniazzi MM, et al. 2005. Cell culture derived AgMNPV bioinsecticide: biological constraints and bioprocess issues. Cytotechnology 48: 27-39. DOI ScienceOn |
4 | Schlaeger EJ. 1996. The protein hydrolysate, Primatone R.L., is a cost-effective multiple growth promoter of mammalian cell culture in serum-containing and serum-free media and displays anti-apoptosis properties. J. Immunol. Methods 194: 191-199. DOI ScienceOn |
5 | Shen CF, Voyer R, Tom R, Kamen A. 2010. Reassessing culture media and critical metabolites that affect adenovirus production. Biotechnol. Prog. 26: 200-207. |
6 | Stavroulakis DA, Kalogerakis N, Behie LA, Iatrou K. 1991. Kinetic data for the Bm-5 insect cell line in repeated-batch suspension cultures. Biotechnol. Bioeng. 38: 116-126. DOI |
7 | Sugiura T, Amann E. 1996. Properties of two insect cell lines useful for the baculovirus expression system in serum-free culture. Biotechnol. Bioeng. 51: 494-499. DOI |
8 | Summers MD. 2006. Milestones leading to the genetic engineering of baculo-viruses as expression vector systems and viral pesticides. Adv. Virus Res. 68: 3-73. DOI ScienceOn |
9 | Toku K, Tanaka J, Yano H, Desaki J, Zhang B, Yang LH, et al. 1998. Microglial cells prevent nitric oxide-induced neuronal apoptosis in vitro. J. Neurosci. Res. 53: 415-425. DOI |
10 | Woo SD, Roh JY, Choi JY, Jin BR. 2007. Propagation of Bombyx mori nucleopolyhedrovirus in nonpermissive insect cell lines. J. Microbiol. 45: 133-138. |
11 | Wood HA, Johnston B, Burand JP. 1982. Inhibition of Autographa californica nuclear polyhedrosis virus replication in high density Trichoplusia ni cell cultures. Virology 119: 245-254. DOI ScienceOn |
12 | Kioukia N, Al-Rubeai M, Zhang Z, Emery AN, Nienow AW, Thomas CR. 1995. A study of uninfected and baculovirus infected Spodoptera frugiperda cells in T- and spinner flasks. Biotechnol. Lett. 17: 7-12. DOI |
13 | Kioukia N, Nienow AW, Emery AN, Al-Rubeai M. 1995. Physiological and environmental factors affecting the growth of insect cells and infection with baculovirus. J. Biotechnol. 38: 243-251. DOI ScienceOn |
14 | Kloppinger M, Fertig G, Fraune E, Miltenburger HG. 1990. Multistage production of Autographa californica nuclear polyhedrosis virus in insect cell cultures. Cytotechnology 4: 271-278. DOI |
15 | Metz SW, Pijlman GP. 2011. Arbovirus vaccines; opportunities for the baculovirus-insect cell expression system. J. Invertebr. Pathol. 107: S16-S30. DOI ScienceOn |
16 | Krieger M, Jahan N, Riehle M, Cao C, Brown M. 2004. Molecular characterization of insulin-like peptide genes and their expression in the African malaria mosquito, Anopheles gambiae. Insect Mol. Biol. 13: 303-315. |
17 | Lauffenburger D, Cozens C. 1989. Regulation of mammalian cell growth by autocrine growth factors: analysis of consequences for inoculum cell density effects. Biotechnol. Bioeng. 33: 1365-1378. DOI ScienceOn |
18 | Mendonça RZ, Palomares LA, Ramirez OT. 1999. An insight into insect cell metabolism through selective nutrient manipulation. J. Biotechnol. 72: 61-75. DOI ScienceOn |
19 | Munger J, Bennett BD, Parikh A, Feng XJ, McArdle J, Rabitz HA, et al. 2010. Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat. Biotechnol. 26: 1179-1186. |
20 | Ohki T, Mikhailenko SV, Arai T, Ishii S, Ishiwata SI. 2012. Improvement of the yields of recombinant actin and myosin V-HMM in the insect cell/baculovirus system by the addition of nutrients to the high-density cell culture. J. Muscle Res. Cell Motil. 33: 351-358. DOI ScienceOn |
21 | Palomares LA, Mena JA, Ramirez OT. 2012. Simultaneous expression of recombinant proteins in the insect cellbaculovirus system: production of virus-like particles. Methods 56: 389-395. DOI ScienceOn |
22 | Polazzi E, Gianni T, Contestabile A. 2001. Microglial cells protect cerebellar granule neurons from apoptosis: evidence for reciprocal signalling. Glia 36: 271-280. DOI ScienceOn |
23 | Eriksson U, Hassel J, Lullau E, Haggstrom L. 2005. Metalloproteinase activity is the sole factor responsible for the growth-promoting effect of conditioned medium in Trichoplusia ni insect cell cultures. J. Biotechnol. 119: 76-86. DOI ScienceOn |
24 | Ferreira TB, Ferreira AL, Carrondo MJT, Alves PM. 2005. Effect of re-feed strategies and non-ammoniagenic medium on adenovirus production at high cell densities. J. Biotechnol. 119: 272-280. DOI ScienceOn |
25 | Hitchman RB, Locanto E, Possee RD, King LA. 2011. Optimizing the baculovirus expression vector system. Methods 55: 52-57. DOI ScienceOn |
26 | Fowlkes J, Winkler M. 2002. Exploring the interface between metallo-proteinase activity and growth factor and cytokine bioavailability. Cytokine Growth Factor Rev. 13: 277-287. DOI ScienceOn |
27 | Gioria VV, Jager V, Claus JD. 2006. Growth, metabolism and baculovirus production in suspension cultures of an Anticarsia gemmatalis cell line. Cytotechnology 52: 113-124. |
28 | Hara K, Funakoshi M, Kawarabata T. 1995. A cloned cell line of Spodoptera exigua has a highly increased susceptibility to the Spodoptera exigua nuclear polyhedrosis virus. Can. J. Microbiol. 41: 1111-1116. DOI |
29 | Hitchman RB, Murguia-Meca F, Danquah J, King LA. 2011. Baculovirus as vectors for human cells and applications in organ transplantation. J. Invertebr. Pathol. 107: S49-S58. DOI ScienceOn |
30 | Ikonomou L, Schneider YJ, Agathos SN. 2003. Insect cell culture for industrial production of recombinant proteins. Appl. Microbiol. Biotechnol. 62: 1-20. DOI |
31 | Ikonomou L, Bastin G, Schneider YJ, Agathos SN. 2001. Design of an efficient medium for insect cell growth and recombinant protein production. In Vitro Cell. Dev. Biol. Anim. 37: 549-559. DOI |
32 | Ikonomou L, Bastin G, Schneider YJ, Agathos SN. 2004. Effect of partial medium replacement on cell growth and protein production for the insect cell line. Cytotechnology 44: 67-76. DOI ScienceOn |
33 | Kim JS, Choi JY, Roh JY, Lee HY, Jang SS, Je YH. 2007. Production of recombinant polyhedra containing Cry1Ac fusion protein in insect cell lines. J. Microbiol. Biotechnol. 17: 739-744. |
34 | Calles K, Svensson I, Lindskog E, Haggstrom L. 2006. Effects of conditioned medium factors and passage number on Sf9 cell physiology and productivity. Biotechnol. Prog. 22: 394-400. DOI ScienceOn |
35 | Doverskog M, Ljunggren J, Ohman L, Haggstrom L. 1997. Physiology of cultured animal cells. J. Biotechnol. 59: 103-115. DOI ScienceOn |
36 | Carinhas N, Bernal V, Monteiro F, Carrondo MJT, Oliveira R, A lves P M. 2 010. I mp roving b aculovirus p roduction a t high cell density through manipulation of energy metabolism. Metab. Eng. 12: 39-52. |
37 | Carinhas N, Bernal V, Yokomizo AY, Carrondo MJT, Oliveira R, Alves PM. 2009. Baculovirus production for gene therapy: the role of cell density, multiplicity of infection and medium exchange. Appl. Microbiol. Biotechnol. 81: 1041-1049. DOI ScienceOn |
38 | Caron AW, Archambault J, Massie B. 1990. High-level recombinant protein production in bioreactors using the baculovirus-insect cell expression system. Biotechnol. Bioeng. 36: 1133-1140. DOI |
39 | Doverskog M, Bertram E, Ljunggren J, ohman L, Sennerstam R, Haggstrom L. 2000. Cell cycle progression in serum free cultures of Sf9 insect cells: modulation by conditioned medium factors and implications for proliferation and productivity. Biotechnol. Progr. 16: 837-846. DOI ScienceOn |
40 | Doverskog M, Tally M, Haggstrom L. 1999. Constitutive secretion of an endogenous insulin-like peptide binding protein with high affinity for insulin in Spodoptera frugiperda (Sf9) cell cultures. Biochem. Biophys. Res. Commun. 265: 674-679. DOI ScienceOn |
41 | Drews M, Paalme T, Vilu R. 1995. The growth and nutrient utilization of the insect cell line Spodoptera frugiperda Sf9 in batch and continuous culture. J. Biotechnol. 40: 187-198. DOI ScienceOn |
42 | Drugmand JC. 2007. Study of the metabolism and physiology of High-Five insect cells for the development of processes for the production of recombinant protein. PhD Thesis, Universite Catholique de Louvain. Louvain-la-Neuve, Belgium. |
43 | Elias CB, Zeiser A, Bedard C, Kamen AA. 2000. Enhanced growth of Sf-9 cells to a maximum density of cells per ml and production of at high cell density by fed batch culture. Biotechnol. Bioeng. 68: 381-388. DOI ScienceOn |
44 | Beas-Catena A, Sanchez-Miron A, Garcia-Camacho F, Contreras Gomez A, Molina-Grima E. 2013. Adaptation of the Spodoptera exigua Se301 insect cell line to grow in serumfree suspended culture. Comparison of SeMNPV productivity in serum-free and serum-containing media. Appl. Microbiol. Biotechnol. 97: 3373-3381. DOI ScienceOn |
45 | Ahm MH, Song M, Oh EY, Jamal A, Kim H, Ko K, et al. 2008. Production of therapeutic proteins with baculovirus expression system in insect cell. Entomol. Res. 38: S71-S78. DOI |
46 | Airenne KJ, Hu YC, Kost TA, Smith RH, Kotin RM, Ono C, et al. 2013. Baculovirus: an insect-derived vector for diverse gene transfer applications. Mol. Ther. 21: 739-749. DOI |
47 | Andersen A, Hansen P, Schaffer L, Kristensen C. 2000. A new secreted insect protein belonging to the immunoglobulin superfamily binds insulin and related peptides and inhibits their activities. J. Biol. Chem. 275: 16948-16953. DOI ScienceOn |
48 | Beas-Catena A, Sanchez-Miron A, Garcia-Camacho F, Molina- Grima E. 2011 Adaptation of the Se301 insect cell line to suspension culture. Effect of turbulence on growth and on production of nucleopolyhedrovirus (SeMNPV). Cytotechnology 63: 543-552. DOI ScienceOn |
49 | Bedard C, Tom R, Kamen A. 1993. Growth, nutrient consumption, and end-product accumulation in Sf-9 and BTI-EAA insect cell cultures: insights into growth limitation and metabolism. Biotechnol. Prog. 9: 615-624. DOI ScienceOn |
50 | Benslimane C, Elias CB, Hawari H, Kamen A. 2005. Insights into the central metabolism of Spodoptera frugiperda (Sf-9) and Trichoplusia ni BTI-Tn-5B1-4 (Tn-5) insect cells by radiolabeling studies. Biotechnol. Prog. 21: 78-86. |
51 | Bernal V, Carinhas N, Yokomizo AY, Carrondo MJT, Alves PM. 2009. Cell density effect in the baculovirus-insect cells system: a quantitative analysis of energetic metabolism. Biotechnol. Bioeng. 104: 162-180. DOI ScienceOn |
52 | Bernal V, Monteiro F, Carinhas N, Ambrosio R, Alves PM. 2010. An integrated analysis of enzyme activities, cofactor pools and metabolic fluxes in baculovirus-infected Spodoptera frugiperda Sf9 cells. J. Biotechnol. 150: 332-342. |
53 | Drugmand JC, Schneider YJ, Agathos SN. 2012. Insect cells as factories for biomanufacturing. Biotechnol. Adv. 30: 1140- 1157. DOI ScienceOn |
54 | Bhatia R, Jesionowski G, Ferrance J, Ataai MM. 1997. Insect cell physiology. Cytotechnology 24: 1-9. |
55 | Calles K, Eriksson U, Haggstrom L. 2006. Effect of conditioned medium factors on productivity and cell physiology in Trichoplusia ni insect cell cultures. Biotechnol. Prog. 22: 653-659. DOI |
56 | Zhang YH, Enden G, Merchuck JC. 2005. Insect cells- baculovirus system: factors affecting growth and low MOI infection. Biochem. Eng. J. 27: 8-16. DOI ScienceOn |
57 | Wu JY, Ruan Q, Lam HYP. 1998. Evaluation of spent medium recycle and nutrient feeding strategies for recombinant protein production in the insect cell-baculovirus process. J. Biotechnol. 66: 109-116. DOI ScienceOn |
58 | Radford KM, Reid S, Greenfield PF. 1997. Substrate limitation in the baculovirus expression vector system. Biotechnol. Bioeng. 56: 32-44. DOI |
59 | Ikonomou L, Peeters-Joris C, Schneider YJ, Agathos SN. 2002. Supernatant proteolytic activities of High-Five insect cells grown in serum-free culture. Biotechnol. Lett. 24: 965-969. DOI ScienceOn |