Effect of Different Biosynthetic Precursors on the Production of Nargenicin ![]() |
Koju, Dinesh
(Institute of Biomolecule Reconstruction, Sun Moon University)
Maharjan, Sushila (Institute of Biomolecule Reconstruction, Sun Moon University) Dhakal, Dipesh (Institute of Biomolecule Reconstruction, Sun Moon University) Yoo, Jin Cheol (Department of Pharmacy, College of Pharmacy, Chosun University) Sohng, Jae Kyung (Institute of Biomolecule Reconstruction, Sun Moon University) |
1 | Cane, D. E. and C. C. Yang. 1984. Biosynthetic origin of the carbon skeleton and oxygen atoms of nargenicin A1. J. Am. Chem. Soc. 106: 784-787. DOI |
2 | Celmer, W. D., G. N. Chmurny, C. E. Moppett, R. S. Ware, P. C. Watts, and E. B. Whipple. 1980. Structure of natural antibiotic CP-47,444. J. Am. Chem. Soc. 102: 4203-4209. DOI |
3 | Chan, Y. A., A. M. Podevels, B. M. Kevany, and M. G. Thomas. 2009. Biosynthesis of polyketide synthase extender units. Nat. Prod. Rep. 26: 90-114. DOI ScienceOn |
4 | Cho, S. S., J. K. Sohng, H. J. Lee, S. J. Park, J. R. Simkhada, and J. C. Yoo. 2009. Quantitative analysis of nargenicin in Nocardia sp. CS682 culture by high performance liquid chromatography. Arch. Pharm. Res. 32: 335-340. DOI ScienceOn |
5 | Gunnarsson, N., A. Eliasson, and J. Nielsen. 2004. Control of fluxes towards antibiotics and the role of primary metabolism in production of antibiotics. Adv. Biochem. Eng. Biotechnol. 88: 137-178. |
6 | Hopwood, D. A. 1997. Genetic contributions to understanding polyketide synthases. Chem. Rev. 97: 2465-2497. DOI ScienceOn |
7 | Iannitelli, R. C. and M. Ikawa. 1980. Effect of fatty acids on action of polyene antibiotics. Antimicrob. Agents Chemother. 17: 861-864. DOI ScienceOn |
8 | Jing, K., X. Hao, and Y. Lu. 2011. Effect of propionate on the production of natamycin with Streptomyces gilvosporeus XM-172. Afr. J. Biotechnol. 10: 10030-10033. |
9 | Katz, L. 1997. Manipulation of modular polyketide synthases. Chem. Rev. 97: 2557-2575. DOI ScienceOn |
10 | Kim, D. J., J. H. Huh, Y. Y. Yang, C. M. Kang, I. H. Lee, C. G. Hyun, et al. 2003. Accumulation of S-adenosyl-L-methionine enhances production of actinorhodin but inhibits sporulation in Streptomyces lividans TK23. J. Bacteriol. 185: 592-600. DOI ScienceOn |
11 |
Kim, S. H., J. C. Yoo, and T. S. Kim. 2009. Nargenicin enhances 1,25-dihydroxyvitamin D3- and all-trans retinoic acidinduced leukemia cell differentiation via |
12 | Lee, P. C., T. Umeyama, and S. Horinouchi. 2002. AfsS is a target of AfsR, a transcriptional factor with ATPase activity that globally controls secondary metabolism in Streptomyces coelicolor A3(2). Mol. Microbiol. 43: 1413-1430. DOI ScienceOn |
13 | Li, C., G. Florova, A. Konstatin, and K. A. Reynolds. 2004. Crotonylcoenzyme A reductase provides methylmalonyl-CoA precursors for monensin biosynthesis by Streptomyces cinnamonensis in an oil-based extended fermentation. Microbiology 150: 3463-3472. DOI ScienceOn |
14 | Li, L. Z., H. Zheng, and Y. Yuan. 2007. Effects of propionate on streptolydigin production and carbon flux distribution in Streptomyces lydicus AS 4.2501. Chin. J. Chem. Eng. 15: 143-149. DOI ScienceOn |
15 | Maharjan, S., D. Koju, H. C. Lee, J. C. Yoo, and J. K. Sohng. 2012. Metabolic engineering of Nocardia sp. CS682 for enhanced production of nargenicin A1. Appl. Biochem. Biotechnol. 166: 805-817. DOI ScienceOn |
16 | Mouslim, J., L. David, G. Petel, and M. Gendraud. 1993. Effect of exogeneous methyl oleate on the time course of some parameters of Streptomyces hygroscopicus NRRL B-1865 culture. Appl. Microbiol. Biotechnol. 39: 585-588. DOI ScienceOn |
17 | Maharjan, S., J. W. Park, Y. J. Yoon, H. C. Lee, and J. K. Sohng. 2010. Metabolic engineering of Streptomyces venezuelae for malonyl-CoA biosynthesis to enhance heterologous production of polyketides. Biotechnol. Lett. 32: 277-282. DOI ScienceOn |
18 | Maharjan, S., T. J. Oh, H. C. Lee, and J. K. Sohng. 2008. Heterologous expression of metK1-sp and afsR-sp in Streptomyces venezuelae for the production of pikromycin. Biotechnol. Lett. 30: 1621-1626. DOI ScienceOn |
19 | Mo, S., Y. H. Ban, J. W. Park, Y. J. Yoo, and Y. J. Yoon. 2009. Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor. J. Ind. Microbiol. Biotechnol. 36: 1473-1482. DOI ScienceOn |
20 | Murli, S., J. Kennedy, L. C. Dayem, J. R. Carney, and J. T. Kealey. 2003. Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production. J. Ind. Microbiol. Biotechnol. 30: 500-509. DOI ScienceOn |
21 | Okamoto, S., A. Lezhava, T. Hosaka, Y. Okamoto-Hosoya, and K. Ochi. 2003. Enhanced expression of S-adenosylmethionine synthetase causes overproduction of actinorhodin in Streptomyces coelicolor A3(2). J. Bacteriol. 185: 601-609. DOI ScienceOn |
22 | Olano, C., F. Lombo, C. Mendez, and J. A. Salas. 2008. Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering. Metab. Eng. 10: 281-292. DOI ScienceOn |
23 | Paudel, S., H. C. Lee, B. S. Kim, and J. K. Sohng. 2011. Enhancement of pradimicin production in Actinomadura hibisca P157-2 by metabolic engineering. Microbiol. Res. 167: 32-39. DOI ScienceOn |
24 | Sohng, J., T. Yamaguchi, C. Seong, K. Baik, S. Park, H. Lee, S. Jang, J. Simkhada, and J. Yoo. 2008. Production, isolation and biological activity of nargenicin from Nocardia sp. CS682. Arch. Pharm. Res. 31: 1339-1345. DOI ScienceOn |
25 | Reeves, A. R., I. A. Brikun, W. H. Cernota, B. I. Leach, M. C. Gonzalez, and J. M. Weber. 2006. Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora erythraea. J. Ind. Microbiol. Biotechnol. 33: 600-609. DOI ScienceOn |
26 | Reeves, A. R., I. A. Brikun, W. H. Cernota, B. I. Leach, M. C. Gonzalez, and J. M. Weber. 2007. Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production. Metab. Eng. 9: 293-303. DOI ScienceOn |
27 | Ryu, Y. G., M. J. Butler, K. F. Chater, and K. J. Lee. 2006. Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor. Appl. Environ. Microbiol. 72: 7132-7139. DOI ScienceOn |
28 | Wang, Y., B. A. Boghigian, and B. A. Pfeifer. 2007. Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene. Appl. Microbiol. Biotechnol. 77: 367-373. DOI ScienceOn |
29 | Yoon, G. S., K. H. Ko, H. W. Kang, J. W. Suh, Y. S. Kim, and Y. W. Ryu. 2006. Characterization of S-adenosylmethionine synthetase from Streptomyces avermitilis NRRL8165 and its effect on antibiotic production. Enzyme Microb. Technol. 39: 466-473. DOI ScienceOn |
30 | Zhao, X. Q., Y. Y. Jin, and H. J. Kwon. 2006. S-Adenosylmethionine (SAM) regulates antibiotic biosynthesis in Streptomyces spp. in a mode independent of its role as a methyl donor. J. Microbiol. Biotechnol. 16: 927-932. |
![]() |