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http://dx.doi.org/10.4014/jmb.1112.12020

Antimicrobial Activity of Licochalcone E Against Staphylococcus aureus and Its Impact on the Production of Staphylococcal Alpha-Toxin  

Zhou, Tiezhong (College of Animal Husbandry and Veterinary, Liaoning Medical University)
Deng, Xuming (College of Animal Science and Veterinary Medicine, Jilin University)
Qiu, Jiazhang (College of Animal Science and Veterinary Medicine, Jilin University)
Publication Information
Journal of Microbiology and Biotechnology / v.22, no.6, 2012 , pp. 800-805 More about this Journal
Abstract
Licochalcone E was firstly isolated from licorice root in 2005, which belongs to the retrochalcone family. Studies on the biological activities of licochalcone E were in the initial stage. In the study, we demonstrated that licochalcone E has potent antimicrobial property against Staphylococcus aureus. Furthermore, via hemolysis, Western blot, and real-time RT-PCR assays, we have shown that subinhibitory concentrations of licochalcone E dose-dependently reduces the production of ${\alpha}$-toxin in both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The data suggest that licochalcone E may deserve further investigation as a potential therapeutic against S. aureus infections, or the structure of licochalcone E may be used as a basis for chemical synthesis of novel anti-S. aureus compounds.
Keywords
Staphylococcus aureus; licochalcone E; alpha-toxin;
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